Re: Capasaicin - you are gonna love this article - more cured mice

[Guest guest]

Dear a

Are you suggesting a prostate massage with Capsicacin creme :-) LOL

Regards

Windsor

[infections] Capasaicin - you are gonna love this article - more cured mice

This stuff cured the diabetes in mice. Now we find it cures prostate cancer.-a Carneshttp://www.newstarget.com/z019964.html<http://www.newstarget.com/z019964.html> NewsTarget.com <http://www.newstarget.com/index.html<http://www.newstarget.com/index.html> > printable articleOriginally published August 14 2006 Pepper Component Hot Enough to Trigger Suicide in Prostate Cancer Cells(press release)by NewsTarget Capsaicin, the stuff that turns up the heat in jalapeños, not only causesthe tongue to burn, it also drives prostate cancer cells to kill themselves,according to studies published in the March 15 issue of Cancer Research. According to a team of researchers from the Oschin ComprehensiveCancer Institute at Cedars-Sinai Medical Center, in collaboration withcolleagues from UCLA, the pepper component caused human prostate cancercells to undergo programmed cell death or apoptosis. Capsaicin induced approximately 80 percent of prostate cancer<http://www.newstarget.com/prostate_cancer.html<http://www.newstarget.com/prostate_cancer.html> > cells growing in mice tofollow the molecular pathways leading to apoptosis. Prostate cancer<http://www.newstarget.com/cancer.html<http://www.newstarget.com/cancer.html> > tumors treated with capsaicin<http://www.newstarget.com/capsaicin.html<http://www.newstarget.com/capsaicin.html> > were about one-fifth the sizeoftumors in non-treated mice. “Capsaicin had a profound anti-proliferative effect on human prostate cancercells <http://www.newstarget.com/cancer_cells.html<http://www.newstarget.com/cancer_cells.html> > in culture,” said SörenLehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Centerand the UCLA School of Medicine. “It also dramatically slowed thedevelopment of prostate <http://www.newstarget.com/prostate_tumors.html<http://www.newstarget.com/prostate_tumors.html> >tumors formed by those human cell lines grown in mouse models.” Lehmann estimated that the dose of pepper extract fed orally to the mice wasequivalent to giving 400 milligrams of capsaicin three times a week to a 200pound man, roughly equivalent to between three and eight fresh habañerapeppers – depending on the pepper’s capsaicin content. Habañeras are thehighest rated pepper for capsaicin content according to the Scoville heatindex. Habañera peppers, which are native to the Yucatan, typically containup to 300,000 Scoville units. The more popular Jalapeño variety from Oaxaca, Mexico, and the southwestUnited States <http://www.newstarget.com/United_States.html<http://www.newstarget.com/United_States.html> > , contains2,500 to 5,000 Scoville units. As described in their study, the scientistsobserved that capsaicin inhibited the activity of NF-kappa Beta, a molecularmechanism that participates in the pathways leading to apoptosis in manycell types. Apoptosis is a normal cellular event in many tissues that maintains abalance between newer replacement cells and aged or worn cells. In contrast,cancer cells seek to be immortal and often dodge apoptosis by mutating orderegulating the genes that participate in programmed cell death. “When we noticed that capsaicin affected NF-kappa Beta, that was anindication that we might expect some of the apoptotic proteins to beaffected,” said the study’s senior author, Koeffler, M.D., directorof Hematology and Oncology, Cedars-Sinai Medical Center, and professor atUCLA. The pepper extract also curbed the growth of prostate cancer cells throughregulation of androgen receptors, the steroid activated proteins thatcontrol expression of specific growth relating genes. In prostate cancer cells whose growth is dependent on testosterone, thepredominant male sex steroid, capsaicin reduced cell proliferation in adose-dependent manner. Increased concentrations of capsaicin caused moreprostate cancer cells to freeze in a non-proliferative state, called G0/G1. Prostate cancer cells that are androgen independent reacted to capsaicin ina similar manner. Capsaicin reduced the amount of androgen receptor that thetumor cells produced, but did not interfere with normal movement of androgenreceptor into the nucleus of the cancer cells where the steroid receptoracts to regulate androgen target genes such as prostate specific antigen(PSA <http://www.newstarget.com/PSA.html<http://www.newstarget.com/PSA.html> > ). Capsaicin also interfered withthe action of androgen receptors even in cells that were modified to produceexcess numbers of androgen receptors. The hot pepper component also reduced cancer cell production of PSA, aprotein that often is produced in high quantities by prostate tumors and cansignal the presence of prostate cancer in men. PSA content in the blood ofmen is used as a diagnostic prostate cancer screening measure. PSA isregulated by androgens, and capsaicin limited androgen-induced increases ofPSA in the cancer cell lines. More men in the United States develop prostate cancer than any other type ofmalignancy. Every year, more than 232,000 new cases of prostate cancer arediagnosed in the U.S., and more than 680,000 develop the disease worldwide.Approximately 30,000 men die from prostate cancer in the U.S. each year,which is about 13 percent of all new cases. Worldwide, there are 221,000deaths – approximately 31 per cent – among men with prostate cancer. Lehman conducted the studies in Koeffler’s laboratory in collaboration withUCLA cancer researchers Akio Mori, O’, Takishi Kumagai, nDesmond, Milena Pervan, and McBride. Mosahiro Kizaki, a formerpost-doctoral fellow in Koeffler’s laboratory who initiated the capsaicinstudies, is currently at the Keio University School of Medicine, Tokyo,Japan. _____ All content posted on this site is commentary or opinion and is protectedunder Free Speech. Truth Publishing LLC takes sole responsibility for allcontent. Truth Publishing sells no hard products and earns no money from therecommendation of products. Newstarget.com is presented for educational andcommentary purposes only and should not be construed as professional advicefrom any licensed practitioner. Truth Publishing assumes no responsibilityfor the use or misuse of this material. For the full terms of usage of thismaterial, visit www.NewsTarget.com/terms.shtml

[Guest guest]

"Lehmann estimated that the dose of pepper extract fed orally to the mice was equivalent to giving 400 milligrams of capsaicin three times a week to a 200 pound man, roughly equivalent to between three and eight fresh habañera peppers – depending on the pepper’s capsaicin content. Habañeras are the highest rated pepper for capsaicin content according to the Scoville heat index. Habañera peppers, which are native to the Yucatan, typically contain up to 300,000 Scoville units."

,

Stop dreaming and go to bed (or go to bed and start dreaming:)), looks like you'll have to get started on Malaisian food EVERY night instead.

Nelly

[infections] Capasaicin - you are gonna love this article - more cured mice

This stuff cured the diabetes in mice. Now we find it cures prostate cancer.-a Carneshttp://www.newstarget.com/z019964.html<http://www.newstarget.com/z019964.html> NewsTarget.com <http://www.newstarget.com/index.html<http://www.newstarget.com/index.html> > printable articleOriginally published August 14 2006 Pepper Component Hot Enough to Trigger Suicide in Prostate Cancer Cells(press release)by NewsTarget Capsaicin, the stuff that turns up the heat in jalapeños, not only causesthe tongue to burn, it also drives prostate cancer cells to kill themselves,according to studies published in the March 15 issue of Cancer Research. According to a team of researchers from the Oschin ComprehensiveCancer Institute at Cedars-Sinai Medical Center, in collaboration withcolleagues from UCLA, the pepper component caused human prostate cancercells to undergo programmed cell death or apoptosis. Capsaicin induced approximately 80 percent of prostate cancer<http://www.newstarget.com/prostate_cancer.html<http://www.newstarget.com/prostate_cancer.html> > cells growing in mice tofollow the molecular pathways leading to apoptosis. Prostate cancer<http://www.newstarget.com/cancer.html<http://www.newstarget.com/cancer.html> > tumors treated with capsaicin<http://www.newstarget.com/capsaicin.html<http://www.newstarget.com/capsaicin.html> > were about one-fifth the sizeoftumors in non-treated mice. “Capsaicin had a profound anti-proliferative effect on human prostate cancercells <http://www.newstarget.com/cancer_cells.html<http://www.newstarget.com/cancer_cells.html> > in culture,” said SörenLehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Centerand the UCLA School of Medicine. “It also dramatically slowed thedevelopment of prostate <http://www.newstarget.com/prostate_tumors.html<http://www.newstarget.com/prostate_tumors.html> >tumors formed by those human cell lines grown in mouse models.” Lehmann estimated that the dose of pepper extract fed orally to the mice wasequivalent to giving 400 milligrams of capsaicin three times a week to a 200pound man, roughly equivalent to between three and eight fresh habañerapeppers – depending on the pepper’s capsaicin content. Habañeras are thehighest rated pepper for capsaicin content according to the Scoville heatindex. Habañera peppers, which are native to the Yucatan, typically containup to 300,000 Scoville units. The more popular Jalapeño variety from Oaxaca, Mexico, and the southwestUnited States <http://www.newstarget.com/United_States.html<http://www.newstarget.com/United_States.html> > , contains2,500 to 5,000 Scoville units. As described in their study, the scientistsobserved that capsaicin inhibited the activity of NF-kappa Beta, a molecularmechanism that participates in the pathways leading to apoptosis in manycell types. Apoptosis is a normal cellular event in many tissues that maintains abalance between newer replacement cells and aged or worn cells. In contrast,cancer cells seek to be immortal and often dodge apoptosis by mutating orderegulating the genes that participate in programmed cell death. “When we noticed that capsaicin affected NF-kappa Beta, that was anindication that we might expect some of the apoptotic proteins to beaffected,” said the study’s senior author, Koeffler, M.D., directorof Hematology and Oncology, Cedars-Sinai Medical Center, and professor atUCLA. The pepper extract also curbed the growth of prostate cancer cells throughregulation of androgen receptors, the steroid activated proteins thatcontrol expression of specific growth relating genes. In prostate cancer cells whose growth is dependent on testosterone, thepredominant male sex steroid, capsaicin reduced cell proliferation in adose-dependent manner. Increased concentrations of capsaicin caused moreprostate cancer cells to freeze in a non-proliferative state, called G0/G1. Prostate cancer cells that are androgen independent reacted to capsaicin ina similar manner. Capsaicin reduced the amount of androgen receptor that thetumor cells produced, but did not interfere with normal movement of androgenreceptor into the nucleus of the cancer cells where the steroid receptoracts to regulate androgen target genes such as prostate specific antigen(PSA <http://www.newstarget.com/PSA.html<http://www.newstarget.com/PSA.html> > ). Capsaicin also interfered withthe action of androgen receptors even in cells that were modified to produceexcess numbers of androgen receptors. The hot pepper component also reduced cancer cell production of PSA, aprotein that often is produced in high quantities by prostate tumors and cansignal the presence of prostate cancer in men. PSA content in the blood ofmen is used as a diagnostic prostate cancer screening measure. PSA isregulated by androgens, and capsaicin limited androgen-induced increases ofPSA in the cancer cell lines. More men in the United States develop prostate cancer than any other type ofmalignancy. Every year, more than 232,000 new cases of prostate cancer arediagnosed in the U.S., and more than 680,000 develop the disease worldwide.Approximately 30,000 men die from prostate cancer in the U.S. each year,which is about 13 percent of all new cases. Worldwide, there are 221,000deaths – approximately 31 per cent – among men with prostate cancer. Lehman conducted the studies in Koeffler’s laboratory in collaboration withUCLA cancer researchers Akio Mori, O’, Takishi Kumagai, nDesmond, Milena Pervan, and McBride. Mosahiro Kizaki, a formerpost-doctoral fellow in Koeffler’s laboratory who initiated the capsaicinstudies, is currently at the Keio University School of Medicine, Tokyo,Japan. _____ All content posted on this site is commentary or opinion and is protectedunder Free Speech. Truth Publishing LLC takes sole responsibility for allcontent. Truth Publishing sells no hard products and earns no money from therecommendation of products. Newstarget.com is presented for educational andcommentary purposes only and should not be construed as professional advicefrom any licensed practitioner. Truth Publishing assumes no responsibilityfor the use or misuse of this material. For the full terms of usage of thismaterial, visit www.NewsTarget.com/terms.shtml

[Guest guest]

Like I said before, I've been hearing about the powerful healing properties of red pepper for a long time. Even my friend surprised me and filled capsules with red pepper for me to combat some kind of respiratory/sinus thing I was dealing with, she insisted that it will cut a cold down, but I never took many of them and ended up throwing the rest out. I've heard of people swearing by the stuff but I hear this about so many things I've become cynical. Maybe it's time to revisit it in capsule form? Anyone here have any experience with it for anything? And does the the prostrate cancer rate of mexicans, who eat a lot of capsaicin in their diets, support this finding? penny a Carnes <pj7@...> wrote: This stuff cured the diabetes in mice. Now we find it cures prostate cancer.-a Carneshttp://www.newstarget.com/z019964.html<http://www.newstarget.com/z019964.html> NewsTarget.com <http://www.newstarget.com/index.html<http://www.newstarget.com/index.html> > printable articleOriginally published

August 14 2006 Pepper Component Hot Enough to Trigger Suicide in Prostate Cancer Cells(press release)by NewsTarget Capsaicin, the stuff that turns up the heat in jalapeños, not only causesthe tongue to burn, it also drives prostate cancer cells to kill themselves,according to studies published in the March 15 issue of Cancer Research. According to a team of researchers from the Oschin ComprehensiveCancer Institute at Cedars-Sinai Medical Center, in collaboration withcolleagues from UCLA, the pepper component caused human prostate cancercells to undergo programmed cell death or apoptosis. Capsaicin induced approximately 80 percent of prostate cancer<http://www.newstarget.com/prostate_cancer.html<http://www.newstarget.com/prostate_cancer.html> >

cells growing in mice tofollow the molecular pathways leading to apoptosis. Prostate cancer<http://www.newstarget.com/cancer.html<http://www.newstarget.com/cancer.html> > tumors treated with capsaicin<http://www.newstarget.com/capsaicin.html<http://www.newstarget.com/capsaicin.html> > were about one-fifth the sizeoftumors in non-treated mice. “Capsaicin had a profound anti-proliferative effect on human prostate cancercells <http://www.newstarget.com/cancer_cells.html<http://www.newstarget.com/cancer_cells.html>

> in culture,” said SörenLehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai Medical Centerand the UCLA School of Medicine. “It also dramatically slowed thedevelopment of prostate <http://www.newstarget.com/prostate_tumors.html<http://www.newstarget.com/prostate_tumors.html> >tumors formed by those human cell lines grown in mouse models.” Lehmann estimated that the dose of pepper extract fed orally to the mice wasequivalent to giving 400 milligrams of capsaicin three times a week to a 200pound man, roughly equivalent to between three and eight fresh habañerapeppers – depending on the pepper’s capsaicin content. Habañeras are thehighest rated pepper for capsaicin content according to the Scoville heatindex. Habañera peppers, which are native to the Yucatan,

typically containup to 300,000 Scoville units. The more popular Jalapeño variety from Oaxaca, Mexico, and the southwestUnited States <http://www.newstarget.com/United_States.html<http://www.newstarget.com/United_States.html> > , contains2,500 to 5,000 Scoville units. As described in their study, the scientistsobserved that capsaicin inhibited the activity of NF-kappa Beta, a molecularmechanism that participates in the pathways leading to apoptosis in manycell types. Apoptosis is a normal cellular event in many tissues that maintains abalance between newer replacement cells and aged or worn cells. In contrast,cancer cells seek to be immortal and often dodge apoptosis by mutating orderegulating the genes that participate in programmed cell death. “When we noticed

that capsaicin affected NF-kappa Beta, that was anindication that we might expect some of the apoptotic proteins to beaffected,” said the study’s senior author, Koeffler, M.D., directorof Hematology and Oncology, Cedars-Sinai Medical Center, and professor atUCLA. The pepper extract also curbed the growth of prostate cancer cells throughregulation of androgen receptors, the steroid activated proteins thatcontrol expression of specific growth relating genes. In prostate cancer cells whose growth is dependent on testosterone, thepredominant male sex steroid, capsaicin reduced cell proliferation in adose-dependent manner. Increased concentrations of capsaicin caused moreprostate cancer cells to freeze in a non-proliferative state, called G0/G1. Prostate cancer cells that are androgen independent reacted to capsaicin ina similar manner. Capsaicin reduced the amount of androgen receptor that thetumor

cells produced, but did not interfere with normal movement of androgenreceptor into the nucleus of the cancer cells where the steroid receptoracts to regulate androgen target genes such as prostate specific antigen(PSA <http://www.newstarget.com/PSA.html<http://www.newstarget.com/PSA.html> > ). Capsaicin also interfered withthe action of androgen receptors even in cells that were modified to produceexcess numbers of androgen receptors. The hot pepper component also reduced cancer cell production of PSA, aprotein that often is produced in high quantities by prostate tumors and cansignal the presence of prostate cancer in men. PSA content in the blood ofmen is used as a diagnostic prostate cancer screening measure. PSA isregulated by androgens, and capsaicin limited androgen-induced increases

ofPSA in the cancer cell lines. More men in the United States develop prostate cancer than any other type ofmalignancy. Every year, more than 232,000 new cases of prostate cancer arediagnosed in the U.S., and more than 680,000 develop the disease worldwide.Approximately 30,000 men die from prostate cancer in the U.S. each year,which is about 13 percent of all new cases. Worldwide, there are 221,000deaths – approximately 31 per cent – among men with prostate cancer. Lehman conducted the studies in Koeffler’s laboratory in collaboration withUCLA cancer researchers Akio Mori, O’, Takishi Kumagai, nDesmond, Milena Pervan, and McBride. Mosahiro Kizaki, a formerpost-doctoral fellow in Koeffler’s laboratory who initiated the capsaicinstudies, is currently at the Keio University School of Medicine, Tokyo,Japan. _____ All content posted on this site is commentary or opinion and is

protectedunder Free Speech. Truth Publishing LLC takes sole responsibility for allcontent. Truth Publishing sells no hard products and earns no money from therecommendation of products. Newstarget.com is presented for educational andcommentary purposes only and should not be construed as professional advicefrom any licensed practitioner. Truth Publishing assumes no responsibilityfor the use or misuse of this material. For the full terms of usage of thismaterial, visit www.NewsTarget.com/terms.shtml

[Guest guest]

Lots of info at the LEF organization: http://search.lef.org/search/default.aspx?s=1 & QUERY=capsaicin Just a few: Treatment of arthritis with topical capsaicin: a double-blind trial. The neuropeptide substance P has been implicated in the pathogenesis of inflammation and pain in arthritis. In this double-blind randomized study, 70 patients with osteoarthritis (OA) and 31 with rheumatoid arthritis (RA) received capsaicin (a substance P depletor) or

placebo for four weeks. The patients were instructed to apply 0.025% capsaicin cream or its vehicle (placebo) to painful knees four times daily. Pain relief was assessed using visual analog scales for pain and relief, a categorical pain scale, and physicians’ global evaluations. Most of the patients continued to receive concomitant arthritis medications. Significantly more relief of pain was reported by the capsaicin-treated patients than the placebo patients throughout the study; after four weeks of capsaicin treatment, RA and OA patients demonstrated mean reductions in pain of 57% and 33%, respectively. These reductions in pain were statistically significant compared with those reported with placebo (P = 0.003 and P = 0.033, respectively). According to the global evaluations, 80% of the capsaicin-treated patients experienced a reduction in pain

after two weeks of treatment. Transient burning was felt at the sites of drug application by 23 of the 52 capsaicin-treated patients; two patients withdrew from treatment because of this side effect. It is concluded that capsaicin cream is a safe and effective treatment for arthritis. Clin Ther 1991 May-Jun;13(3):383-95 A double-blind evaluation of topical capsaicin in pruritic psoriasis. BACKGROUND: Substance P, an undecapeptide neurotransmitter, has been implicated in the pathophysiology of psoriasis and pruritus. OBJECTIVE: Safety and efficacy of topical capsaicin, a potent substance P depletor, were evaluated in patients

with pruritic psoriasis. METHODS: Patients applied capsaicin 0.025% cream (n = 98) or vehicle (n = 99) four times a day for six weeks in this double-blind study. Efficacy was based on a physician’s global evaluation and a combined psoriasis severity score including scaling, thickness, erythema and pruritus. RESULTS: Capsaicin-treated patients demonstrated significantly greater improvement in global evaluation (p = 0.024 after four weeks and p = 0.030 after six weeks) and in pruritus relief (p = 0.002 and p = 0.060, respectively), as well as a significantly greater reduction in combined psoriasis severity scores (p = 0.030 and p = 0.036, respectively). The most frequently reported side effect in both treatment groups was a transient burning sensation at application sites. CONCLUSION: Topically applied capsaicin effectively treats pruritic psoriasis,

a finding that supports a role for substance P in this disorder. J Am Acad Dermatol 1993 Sep;29(3):438-42 Inhibition of human neutrophil 5-lipoxygenase activity by gingerdione, shogaol, capsaicin and related pungent compounds. A series of structurally related pungent natural products including capsaicin, gingerol, and gingerdione among others were evaluated and found to be potent inhibitors of 5-HETE biosynthesis in intact human leukocytes, with IC50 values of 100 and 15 microM for capsaicin and gingerdione, respectively. Several compounds within this series were also found to inhibit PGE2 formation, with the most potent being

gingerdione (IC50 = 18 microM). These and other data indicate that members of the capsaicin/gingerol family of pungent compounds can act as dual inhibitors of arachidonic acid metabolism, which could account in part for the antiinflammatory and analgesic properties of compounds within this group. Prostaglandins Leukot Med 1986 Oct;24(2-3):195-8 REPORT What Is Nuclear Factor-Kappa Beta? Capsaicin, the main ingredient in red pepper, has both anti-inflammatory and anti-cancer effects.81-83 Red pepper compounds have long been used to manage inflammatory joint conditions.37 Capsaicin inhibits the induction of two inflammation-provoking enzymes in stimulated macrophage immune cells.82 This effect is attributable to its inhibition of NFkB activation.83 Capsaicin also induces cell death in many cancers by modulating NFkB.81 Like curcumin, capsaicin inhibits the growth of adult T-cell leukemia cells by impairing NFkB activation.84 Capsaicin further impairs cancer progression by reducing levels of vascular endothelial growth factor, thus depriving growing cancers of nutrients.85 CHILLI PEPPERS It's the fiery part of chillies called capsaicin that has the power. Eating a chilli will help to suppress your appetite. Researchers found eating chillies also slightly raises metabolism. There is more vitamin C in a green chilli, weight

for weight,than citrus fruits. While red chillies contain more vitamin A than carrots.

[Guest guest]

Penny Houle wrote:

> *Lots of info at the LEF organization:*

> *http://search.lef.org/search/default.aspx?s=1 & QUERY=capsaicin

> <http://search.lef.org/search/default.aspx?s=1 & QUERY=capsaicin>*

> **

>

> *What Is Nuclear Factor-Kappa Beta? *

> **

It's a pathway thrue the cellmembran, see Marie Kroun pages

http://*LymeRICK*.net/*NFkB*.htm

>

> *Capsaicin*, the main ingredient in red pepper, has both

> anti-inflammatory and anti-cancer effects.81-83 Red pepper compounds

> have long been used to manage inflammatory joint conditions.37

> Capsaicin inhibits the induction of two inflammation-provoking enzymes

> in stimulated macrophage immune cells.82 This effect is attributable

> to its inhibition of NFkB activation.83 Capsaicin also induces cell

> death in many cancers by modulating NFkB.81 Like curcumin, capsaicin

> inhibits the growth of adult T-cell leukemia cells by impairing NFkB

> activation.84 Capsaicin further impairs cancer progression by reducing

> levels of vascular endothelial growth factor, thus depriving growing

> cancers of nutrients.85

--

Per Sjöholm

Stockholm, Sweden

[Guest guest]

Ouch!

Seriously, you could take cayenne pepper in pill form. I'm still

trying to find out if taking capsaicin in any form would help. There

seems to be indications that cayenne pepper helps with diabetes and

weight loss.

a

> Dear a

> Are you suggesting a prostate massage with Capsicacin creme :-) LOL

> Regards

> Windsor

> [infections] Capasaicin - you are gonna

love this article - more cured mice

>

>

>

>

> This stuff cured the diabetes in mice. Now we find it cures

prostate cancer.

> -a Carnes

>

> http://www.newstarget.com/z019964.html

> <http://www.newstarget.com/z019964.html>

>

> NewsTarget.com <http://www.newstarget.com/index.html

> <http://www.newstarget.com/index.html> > printable article

>

> Originally published August 14 2006

>

> Pepper Component Hot Enough to Trigger Suicide in Prostate Cancer

Cells

> (press release)

>

> by NewsTarget

>

> Capsaicin, the stuff that turns up the heat in jalapeños, not

only causes

> the tongue to burn, it also drives prostate cancer cells to kill

themselves,

> according to studies published in the March 15 issue of Cancer

Research.

>

> According to a team of researchers from the Oschin

Comprehensive

> Cancer Institute at Cedars-Sinai Medical Center, in collaboration

with

> colleagues from UCLA, the pepper component caused human prostate

cancer

> cells to undergo programmed cell death or apoptosis.

>

> Capsaicin induced approximately 80 percent of prostate cancer

> <http://www.newstarget.com/prostate_cancer.html

> <http://www.newstarget.com/prostate_cancer.html> > cells growing

in mice to

> follow the molecular pathways leading to apoptosis. Prostate

cancer

> <http://www.newstarget.com/cancer.html

> <http://www.newstarget.com/cancer.html> > tumors treated with

capsaicin

> <http://www.newstarget.com/capsaicin.html

> <http://www.newstarget.com/capsaicin.html> > were about one-fifth

the size

> of

> tumors in non-treated mice.

>

> " Capsaicin had a profound anti-proliferative effect on human

prostate cancer

> cells <http://www.newstarget.com/cancer_cells.html

> <http://www.newstarget.com/cancer_cells.html> > in culture, " said

Sören

> Lehmann, M.D., Ph.D., visiting scientist at the Cedars-Sinai

Medical Center

> and the UCLA School of Medicine. " It also dramatically slowed the

> development of prostate

<http://www.newstarget.com/prostate_tumors.html

> <http://www.newstarget.com/prostate_tumors.html> >

> tumors formed by those human cell lines grown in mouse models. "

>

> Lehmann estimated that the dose of pepper extract fed orally to

the mice was

> equivalent to giving 400 milligrams of capsaicin three times a

week to a 200

> pound man, roughly equivalent to between three and eight fresh

habañera

> peppers - depending on the pepper's capsaicin content. Habañeras

are the

> highest rated pepper for capsaicin content according to the

Scoville heat

> index. Habañera peppers, which are native to the Yucatan,

typically contain

> up to 300,000 Scoville units.

>

> The more popular Jalapeño variety from Oaxaca, Mexico, and the

southwest

> United States <http://www.newstarget.com/United_States.html

> <http://www.newstarget.com/United_States.html> > , contains

> 2,500 to 5,000 Scoville units. As described in their study, the

scientists

> observed that capsaicin inhibited the activity of NF-kappa Beta,

a molecular

> mechanism that participates in the pathways leading to apoptosis

in many

> cell types.

>

> Apoptosis is a normal cellular event in many tissues that

maintains a

> balance between newer replacement cells and aged or worn cells.

In contrast,

> cancer cells seek to be immortal and often dodge apoptosis by

mutating or

> deregulating the genes that participate in programmed cell death.

>

> " When we noticed that capsaicin affected NF-kappa Beta, that was

an

> indication that we might expect some of the apoptotic proteins to

be

> affected, " said the study's senior author, Koeffler,

M.D., director

> of Hematology and Oncology, Cedars-Sinai Medical Center, and

professor at

> UCLA.

>

> The pepper extract also curbed the growth of prostate cancer

cells through

> regulation of androgen receptors, the steroid activated proteins

that

> control expression of specific growth relating genes.

>

> In prostate cancer cells whose growth is dependent on

testosterone, the

> predominant male sex steroid, capsaicin reduced cell

proliferation in a

> dose-dependent manner. Increased concentrations of capsaicin

caused more

> prostate cancer cells to freeze in a non-proliferative state,

called G0/G1.

>

> Prostate cancer cells that are androgen independent reacted to

capsaicin in

> a similar manner. Capsaicin reduced the amount of androgen

receptor that the

> tumor cells produced, but did not interfere with normal movement

of androgen

> receptor into the nucleus of the cancer cells where the steroid

receptor

> acts to regulate androgen target genes such as prostate specific

antigen

> (PSA <http://www.newstarget.com/PSA.html

> <http://www.newstarget.com/PSA.html> > ). Capsaicin also

interfered with

> the action of androgen receptors even in cells that were modified

to produce

> excess numbers of androgen receptors.

>

> The hot pepper component also reduced cancer cell production of

PSA, a

> protein that often is produced in high quantities by prostate

tumors and can

> signal the presence of prostate cancer in men. PSA content in the

blood of

> men is used as a diagnostic prostate cancer screening measure.

PSA is

> regulated by androgens, and capsaicin limited androgen-induced

increases of

> PSA in the cancer cell lines.

>

> More men in the United States develop prostate cancer than any

other type of

> malignancy. Every year, more than 232,000 new cases of prostate

cancer are

> diagnosed in the U.S., and more than 680,000 develop the disease

worldwide.

> Approximately 30,000 men die from prostate cancer in the U.S.

each year,

> which is about 13 percent of all new cases. Worldwide, there are

221,000

> deaths - approximately 31 per cent - among men with prostate

cancer.

>

> Lehman conducted the studies in Koeffler's laboratory in

collaboration with

> UCLA cancer researchers Akio Mori, O', Takishi

Kumagai, n

> Desmond, Milena Pervan, and McBride. Mosahiro Kizaki, a

former

> post-doctoral fellow in Koeffler's laboratory who initiated the

capsaicin

> studies, is currently at the Keio University School of Medicine,

Tokyo,

> Japan.

>

> _____

>

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