Re: penicillin + diflucan (antagonism of antimicrobials)

[Guest guest]

> I take both together. I see no point at all in alternating them.

It's worth bearing in mind that bacteriostatics have been considered

antagonistic with cidals like penicillin, in classical fast-growing,

fast-curing infections. I haven't studied this issue very much.

The kinetics of killing of bacteria in vitro by at least some B-lactams

has been found to be a linear function of growth rate. I don't think

this applies to every single B-lactam though. They all target the PBPs

of the bacterial envelope, but in most (all?) bacteria, there are a few

different PBPs... I think one of them or some of them, eg, are involved

primarily/only in septation, the formation of the cell wall between the

two daughter cells when the cell divides.

I'm not sure all this matters as much in the case of a " quagmire "

infection that responds only to multi-month or multi-year treatment...

but I don't have a formal theory about that.

Point being that there could be at least one efficacy-related argument

for not doing pen and fluc simultaneously, but I think that argument is

kinda murky.