Re:Abx/IS supression/synergy, etc.. Kate/Penny

[Guest guest]

Penny:

I also object when Drs. say it's the supressive qualities of some abx

that are responsible for improvement, mainly becuase I think they

ignore the antimicrobial effects (which is what I think is

responsible for the improvements)

But there's no denying the fact some are suppressive (or modulatory-

which ever term you want to use).

And When HCQ is mixed with some- there's more suppression.. but HCQ

has quite a few anti-poarasitic, anti- viral- anti bacterial

properties too... and can boost some reactions when combined with

other drugs..

You just have to be a mad chemist to know what to mix with what..

See these references.. and there's more if you do a search:

1 ) Clin Immunol. 2004 Dec;113(3):270-7.

Minocycline inhibits antigen processing for presentation to human T

cells: additive inhibition with chloroquine at therapeutic

concentrations.

Kalish RS, Koujak S.

Department of Dermatology, State University of New York at Stony

Brook, Stony Brook, NY 11794-8165, USA. richard.kalish@...

2) Vopr Virusol. 1990 Mar-Apr;35(2):146-50.

[Lysosomotropic agents inhibit the penetration of arenaviruses into a

culture of BHK-21 and Vero cells]

3)J Clin Invest. 1997 Sep 15;100(6):1640-6.

Chloroquine induces human mononuclear phagocytes to inhibit and kill

Cryptococcus neoformans by a mechanism independent of iron

deprivation.

Levitz SM, on TS, Tabuni A, Liu X.

The Memorial Department of Clinical Research and the Department

of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA.

slevitz@...

> > Of course Steroids can be used anytime as suppressives- not

without

> > cost to the body though.. there are other drugs that can supress

the

> > immune system not so far upstream.... matter of fact alot of abx

are

> > suppressive..

> >

> My son's immunologist told me that this is not generally true, but

> can happen in exceptional cases. So do you have some studies to the

> contrary that I should show him?

>

> - Kate

>

[Guest guest]

Oh yeah, I totally agree with you on the basic premise that some abx are immunosuppressive. Sorry if I implied otherwise. I just got off on a rant, as I often do. Forgot the point. :-) pennyBarb Peck <egroups1bp@...> wrote: Penny:I also object when Drs. say it's the supressive qualities of some abx that are responsible for improvement, mainly becuase I think they ignore the antimicrobial effects (which is what I think is responsible for the

improvements)But there's no denying the fact some are suppressive (or modulatory- which ever term you want to use).And When HCQ is mixed with some- there's more suppression.. but HCQ has quite a few anti-poarasitic, anti- viral- anti bacterial properties too... and can boost some reactions when combined with other drugs..You just have to be a mad chemist to know what to mix with what..See these references.. and there's more if you do a search: 1 ) Clin Immunol. 2004 Dec;113(3):270-7.Minocycline inhibits antigen processing for presentation to human T cells: additive inhibition with chloroquine at therapeutic concentrations.Kalish RS, Koujak S.Department of Dermatology, State University of New York at Stony Brook, Stony Brook, NY 11794-8165, USA. richard.kalishstonybrook (DOT) edu2) Vopr Virusol. 1990

Mar-Apr;35(2):146-50.[Lysosomotropic agents inhibit the penetration of arenaviruses into a culture of BHK-21 and Vero cells]3)J Clin Invest. 1997 Sep 15;100(6):1640-6.Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation.Levitz SM, on TS, Tabuni A, Liu X.The Memorial Department of Clinical Research and the Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA. slevitzmed-med1 (DOT) bu.edu> > Of course Steroids can be used anytime as suppressives- not without> > cost to the body though.. there are other drugs that can supress the> > immune system not so far upstream.... matter of fact alot of abx are> > suppressive..> >> My son's immunologist told me that this is not generally true, but > can happen in exceptional cases. So do you have some studies to the > contrary that I should show him?> > - Kate>

[Guest guest]

BArb'Some of what is possably not observable when doing antimicrobial

studies is the signal blocking that throwing in an antibiotic can

create. Our infections are switchable from making us feel OK to

switching into a spiral of ugliness. Throw a drug into the middle of

a signal and you stop the harmony of the infection.QUORUM SENSING.

> > > Of course Steroids can be used anytime as suppressives- not

> without

> > > cost to the body though.. there are other drugs that can

supress

> the

> > > immune system not so far upstream.... matter of fact alot of

abx

> are

> > > suppressive..

> > >

> > My son's immunologist told me that this is not generally true,

but

> > can happen in exceptional cases. So do you have some studies to

the

> > contrary that I should show him?

> >

> > - Kate

> >

>