Systemic infections and inflammation affect chronic neurodegeneration

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http://www.nature.com/nri/journal/v7/n2/abs/nri2015.html

Systemic infections and inflammation affect chronic neurodegeneration

V. Hugh 1, Colm Cunningham1 and Clive Holmes1

Abstract

It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.

Author affiliations

V. Hugh , Colm Cunningham and Clive Holmes are at the Southampton Neuroscience Group, School of Biological Sciences and School of Medicine, University of Southampton, Southampton SO16 7PX, UK.

Correspondence to: V. Hugh 1 Email: vhp@...

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Thanks, Nelly. I added this to our links section. And want to remind you all that if you feel you've come across an important study, you can add it to the research folder in the links section at the I & I group home site. infections/links thanks, pennyNelly Pointis <janel@...> wrote: http://www.nature.com/nri/journal/v7/n2/abs/nri2015.html Systemic infections and inflammation affect chronic neurodegeneration V. Hugh 1, Colm Cunningham1 and Clive Holmes1 Abstract It is well known that systemic infections cause flare-ups of disease in individuals with asthma and

rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration. Author affiliations V. Hugh , Colm Cunningham and Clive Holmes are at the Southampton Neuroscience Group, School of Biological Sciences and School of Medicine, University of Southampton, Southampton SO16 7PX, UK. Correspondence to: V. Hugh 1 Email: vhp@....uk