Re: First Antibody That Detects Only Known Cause Of Lou Gehrig's Disease Developed

[Guest guest]

a

I watched a brilliant documentary on ALS a couple of weeks ago.The

beauty of the docuymentary was that a group of people- non medical-

bred all these ALS mice and threw every treatment known to man at

them constantly and the only treatment that bouhgt a few months of

relief was a LEPROSY DRUG.Now on this list we all know that leprosy

is caused by a mycoplasma like organism that only grows on mouse feet

pads- mycoplasma leprae..Now that's close to believing a pathogen or

more importantly it's toxic byproducts may be at work.

>

> Please note the " 114 mutations " paragraph. I would be interested in

any

> comments on this. Some believe ALS has underlying infection(s) as

the cause,

> ie Dr. Garth Nicolson.

>

> a Carnes

>

>

>

>

> Univerity ofToronto <http://www.utoronto.ca/>

> Date: May 14, 2007

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>

> First Antibody That Detects Only Known Cause Of Lou Gehrig's Disease

> Developed

>

>

> Science Daily <http://www.sciencedaily.com/> - Researchers at the

> University of Toronto's Faculty of Medicine have developed the first

> antibody that detects the only known cause of amyotrophic lateral

sclerosis

> (ALS), also called Lou Gehrig's disease.

>

> ALS is a progressive and usually fatal neurological disorder that

attacks

> the nerves and muscles. Currently there is no known cure or

effective

> treatments. The latest findings, published in the online edition of

Nature

> Medicine on May 7th, are significant as they provide the world's

first tool

> for recognizing misfolded conformations of the enzyme superoxide-

dimutase-1

> (SOD1). Mutations in the gene encoding SOD1 cause approximately one

to two

> per cent of all ALS cases.

>

> " This antibody will enable researchers to investigate whether

misfolded SOD1

> is involved in other forms of ALS, " said Professor Janice on

> (Laboratory Medicine and Pathobiology) Canada Research Chair in the

> Molecular Mechanics of ALS at the Centre for Research in

Neurodegenerative

> Diseases, and one of the lead authors of the study. " This is

important to

> determining if SOD1 is relevant in ALS cases that are not caused by

> mutations in SOD1. If this is the case, then the antibody could

potentially

> be used in biomarker studies to facilitate earlier diagnosis of the

> disease. "

>

> The antibody, named SOD1-exposed-dimer-interface antibody (SEDI-

antibody),

> also opens up the possibility of developing immunization strategies

for the

> treatment of ALS caused by SOD1 mutations, according to Professor

Avi

> Chakrabartty (Medical Biophysics and Biochemistry, Ontario Cancer

Institute

> - University Health Network), senior author of the study. " The SEDI

antibody

> also has utility in drug discovery efforts for identifying chemical

> chaperones that prevent or reduce misfolding of SOD1 in ALS , " said

> Chakrabartty .

>

> Over 114 mutations have been identified and it is not yet known how

so many

> different mutations result in the same disease, while the normal

enzymatic

> function of SOD1 is not affected. Approximately 3,000 Canadians

currently

> live with ALS, which causes complete paralysis and death usually

within two

> to five years.

>

> The research was funded by the Neuromuscular Research Partnership

of the

> Canadian Institutes of Health Research, the ALS Society of Canada

and the

> Muscular Dystrophy Association of Canada; the ALS Association (US),

the

> Motor Neurone Disease Association (UK) and the Temerety Family

Trust.

>

> The study will be published in the June print edition of Nature

Medicine.

>

> Note: This story has been adapted from a news release issued by

University

> Of Toronto.

>

>

>

>

> _____

>

> See what's free at AOL.com <http://www.aol.com?

ncid=AOLAOF00020000000503> .

>