Guest guest Posted May 26, 2007 Report Share Posted May 26, 2007 > The question is, just how many odd (odd but wild-type) alleles were bred into them in the first place, when they were created? No one seems to ever go into that. I don't understand why not. And the big question is, is there any chance any of the alleles are mutant (non-wild-type) ones? That's where you really risk creating something that's irrelevant to natural disease (assuming mutant alleles are not involved in human immune disease). Hmm, it occured to me that non-functional mutant alleles contributing to disease, if recessive (I assume most would be?), should be obvious. All you'd have to do is outcross your line, and the F1 progeny should be disease free. Quote Link to comment Share on other sites More sharing options...
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