Re: Re; Matt- Abx Reactions ( was Penicillin for psoriasis)

[Guest guest]

Hey Barb

What are the implications of a histamine rash versus a non-histamine

rash? Do you think that the rash could have been something other

than an allergic reaction to one of the antibiotics?

I was prescribed prednisone and hydroxyzine for the rash. The rash

did itch, but not unbearably so. The hydroxyzine helped that.

What do you mean by " skin manifestations " ? I've heard that

antibiotics can sometimes provoke a bulls-eye rash in Lyme

patients. Is that what you have in mind? Are their other examples?

I can see how hydroxyzine could be used for anxiety. The high doses

of prednisone severely aggravated my insomnia and hydroxyzine helped

reverse that.

Matt

>

> Matt:

>

> Do you know if your " allergic " reaction was due to histamine

release?

>

> I have often wondered if a person could take hydroxyzine along

with

> some of the abx coctails that we concoct.. hydroxyzine is an

amazing

> drug for skin manifestations (like rash, contact dermatitis,

hives,

> etc..) it's also used for anexiety (it crosses the BBB).

>

> Barb

>

>

>

[Guest guest]

Matt:

Histamine release is USUALLY the culprit in most normal (not

s) allergic skin reactions.

I think the drug reactions activate T-ALpha is what you have to

worry about.. but I am not sure if steroids are given or not in that

case (it looks controversial in the article cited below).

So it probably depends on whether you had a true SJ reaction (did

you actually lose some skin?) how much of the body was covered (100%)

and whether it cleared with normal skin resulting (not hypo or hyper

pigmented afterwards.)

I used the term skin manisfestations as an umbrella phrase becuase

there's just SO many lesions that can crop up on skin.-

Is your skin OK now (i.e. can you go in the sun without problems? -

no hyperpigmentation, )

http://dermatology.cdlib.org/DOJvol8num1/reviews/drugrxn/ghislain.html

Barb

> >

> > Matt:

> >

> > Do you know if your " allergic " reaction was due to histamine

> release?

> >

> > I have often wondered if a person could take hydroxyzine along

> with

> > some of the abx coctails that we concoct.. hydroxyzine is an

> amazing

> > drug for skin manifestations (like rash, contact dermatitis,

> hives,

> > etc..) it's also used for anexiety (it crosses the BBB).

> >

> > Barb

> >

> >

> >

>

[Guest guest]

>

> Matt:

>

> Histamine release is USUALLY the culprit in most normal (not

> s) allergic skin reactions.

> I think the drug reactions activate T-ALpha is what you have to

> worry about.. but I am not sure if steroids are given or not in

that

> case (it looks controversial in the article cited below).

>

> So it probably depends on whether you had a true SJ reaction

(did

> you actually lose some skin?) how much of the body was covered

(100%)

> and whether it cleared with normal skin resulting (not hypo or

hyper

> pigmented afterwards.)

*****I'm pretty sure it wasn't stevens-johnson. I didn't lose any

skin. About 90% of my body was covered. In some areas the dots

coalesced to form large regions of contiguous red skin, as on my

face. My feet and the palms of my hands were largely, but not

entirely, spared.

>

> I used the term skin manisfestations as an umbrella phrase becuase

> there's just SO many lesions that can crop up on skin.-

>

> Is your skin OK now (i.e. can you go in the sun without problems? -

> no hyperpigmentation, )

*******No hyperpigmentation. Can I go in the sun, you ask? I've

been strictly avoiding sunshine for, I think, 2.5 years. I'm done

with that experiment for now. I'm just now re-introducing light.

No skin reactions. The worst of the rash went away after about 2

weeks (with help from prednisone) but I had this low-grade

reactivity to heat and irritation (rubbing, scratching, etc.). My

skin would get plenty red in response, but would resolve in maybe an

hour after removing the stimulus. After about a year (the acute

reaction occured a year ago) I don't have that reaction much

anymore. It never happened before the abx-induced rash. I wonder

why the last of that reaction took so long to finally resolve.

>