long-term control of resistance-prone bugs

[Guest guest]

> ,

> This leads me to ask what about phages? Any thoughts?

>

> a Carnes

>

Phage, enzymes, and other large-molecules all have some common

limitations. They are likely to provoke antibodies in some cases,

which can inactivate them or even cause hairy reactions. They also may

not be too easy to target to cytosol, which sometimes matters,

sometimes not. But, there's at least some hope.

Lot of people are working on antibacterial peptides from

macro-organisms. Actually, they have been for a while. Why none of

their molecules have really hit the clinic, I don't know.

One idea that's been thought of is maybe just pull one of the old

drugs out of the clinic. In time (decades), populations of Sa and

other resistance-gathering organisms may regain sensitivity to the

disused molecule. This may not happen, though, for every drug. It's

only gonna happen if the resistance-conferring mutation confers some

kind of small or very small, but non-infinitessimal, disadvantage.

We'll definitely have to figure out something.