Re: butyrate for gut infections

[Guest guest]

Just remembered where I picked up that citation from. Dr. Wheldon:

http://www.cpnhelp.org/my_md_is_tolerating_my_ex

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> I searched this forum for butyrate and didn't notice that anyone had

> cited this article yet:

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> http://tinyurl.com/yuf7qr

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>

[Guest guest]

Dear Matt

You could always try readily available gamma hydroxy butyrate :-)

Regards

R

[infections] butyrate for gut infections

I searched this forum for butyrate and didn't notice that anyone had cited this article yet:http://tinyurl.com/yuf7qrThis paper is free, as is the "comment in" editorial. I read the editorial, but not the original paper.The editorial says that butyrate induces the intestinal epithelia to produce an antimicrobial peptide. Rabbits were infected with Shigella and then once diarrhea was noted, half of the rabbits were given 0.14 mmol/kg of sodium butyrate by mouth twice daily. The other half were given saline as a negative control. Butyrate was reported to suppress fecal titers of shigella 100-fold in a day, and 1000-fold in 2 days, compared with the controls. This was said to mirror clinical improvements.Apparently Shigella has a way of shutting off the host's production of the antimicrobial peptide. Butyrate at the doses used in the rabbits restored their production of the antimicrobial peptides.Presumably this might be applicable to other gut infections. I don't know what the side effects of butyrate would be. Sodium butyrate is available commercially:http://www.nextag.com/sodium-butyrate/search-htmlthough I haven't crunched the numbers to see if the usual dose is on par with that used in the rabbits.Another approach, apparently, is to consume fibers that are known to be fermented by gut bacteria into butyrate. I haven't bothered to remember which fibers those are. Commensal gut bacteria appear to be the usual source of butyrate. Antibiotics likely reduce the endogenous production of butyrate by killing off commensal bacteria, which I'm guessing might predispose to secondary gut infections.In my case, though, I avoid "FODMAPs" since they may provoke small intestinal bacterial overgrowth. Doing that, along with using vancomycin to treat C diff resolved my decades-long GI problems. So I'm not in the market for butyrate. Just thought I'd mention it.Matt

[Guest guest]

My guess is that even if we don't have gut symptoms, we may have a bacterial imbalance in the gut that is not helping our overall condition. Kind of a supporting player or secondary reseeding ground. So this might be very good to investigate even if symptoms don't appear to be present. Thanks, Matt. penny p.s. Can you find a comparable one for sinuses now? :-) phagelod <mpalmer@...> wrote: I searched this forum for

butyrate and didn't notice that anyone had cited this article yet:http://tinyurl.com/yuf7qrThis paper is free, as is the "comment in" editorial. I read the editorial, but not the original paper.The editorial says that butyrate induces the intestinal epithelia to produce an antimicrobial peptide. Rabbits were infected with Shigella and then once diarrhea was noted, half of the rabbits were given 0.14 mmol/kg of sodium butyrate by mouth twice daily. The other half were given saline as a negative control. Butyrate was reported to suppress fecal titers of shigella 100-fold in a day, and 1000-fold in 2 days, compared with the controls. This was said to mirror clinical improvements.Apparently Shigella has a way of shutting off the host's production of the antimicrobial peptide. Butyrate at the doses used in the rabbits restored their production of the

antimicrobial peptides.Presumably this might be applicable to other gut infections. I don't know what the side effects of butyrate would be. Sodium butyrate is available commercially:http://www.nextag.com/sodium-butyrate/search-htmlthough I haven't crunched the numbers to see if the usual dose is on par with that used in the rabbits.Another approach, apparently, is to consume fibers that are known to be fermented by gut bacteria into butyrate. I haven't bothered to remember which fibers those are. Commensal gut bacteria appear to be the usual source of butyrate. Antibiotics likely reduce the endogenous production of butyrate by killing off commensal bacteria, which I'm guessing might predispose to secondary gut infections.In my case, though, I avoid "FODMAPs" since they may provoke small intestinal bacterial overgrowth.

Doing that, along with using vancomycin to treat C diff resolved my decades-long GI problems. So I'm not in the market for butyrate. Just thought I'd mention it.Matt