Guest guest Posted June 11, 2007 Report Share Posted June 11, 2007 Zith is prescribed like candy by the DOcs around here. It's not metabolized thru the P450- threfore don't have to worry about it interferring with metabolism of drugs that do ... It's processed thru the biliary system- and I had a big problem with it after only being on it 2 days... I all of a sudden was aware of either my gall bladder or my Liver. Immediate blood tests showed an increased total bilirubin. That's the only time I've taken it- and I stopped after 2 days. Barb > > > > > >> > > > > > > >> > > > > > > >> > This is some enormous new disease loci study covering > > > > seven > > > > > >> common > > > > > >> > diseases... 2-3,000 individuals in each group. I don't > > > > know > > > > > >> if that > > > > > >> > makes it the biggest study of it's kind for some of > > > > these > > > > > >> diseases - > > > > > >> > but I'm guessing so, since 50 labs worked on this > > > > cooperative. > > > > > >> > > > > > > >> > I'm posting it for Tony... > > > > > >> > > > > > > >> > " [...] Case-control comparisons identified 24 > > > > independent > > > > > >> association > > > > > >> > signals at P < 5e-7: 1 in bipolar disorder, 1 in > > > > coronary > > > > > >> artery > > > > > >> > disease, 9 in Crohn's disease, 3 in rheumatoid > > > > arthritis, 7 > > > > > >> in type > > > > > >> 1 > > > > > >> > diabetes and 3 in type 2 diabetes. [...] We observed > > > > > >> association at > > > > > >> > many previously identified loci, and found compelling > > > > > >> evidence that > > > > > >> > some loci confer risk for more than one of the diseases > > > > > >> studied. > > > > > >> [...] > > > > > >> > The importance of appropriately large samples was > > > > confirmed > > > > > >> by the > > > > > >> > modest effect sizes observed at most loci identified. " > > > > > >> > > > > > > >> > > > > > > >> > > > > > > http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html> > > > > > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html> > > > > > > >> > > > > > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html> > > > > > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html > > <http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html> > > > > > > > > > >> > > > > > > >> > Haha, you'll like that last sentence, Tony. Modest > > > > effect > > > > > >> sizes. > > > > > >> > Sounds like no one gene makes a real big difference in > > > > any > > > > > >> of these > > > > > >> > diseases. > > > > > >> > > > > > > >> > I don't think that rules out the possibility that some > > > > of > > > > > >> them could > > > > > >> > be autoimmune diseases (in some stronger or weaker > > > > sense), > > > > > >> as there > > > > > >> > are sooo many genes that can influence thresholds for > > > > loss of > > > > > >> > self-tolerance. But it does tend to make it seem more > > > > > >> likely that > > > > > >> > something big is missing in the ideas most people have > > > > of > > > > > >> these > > > > > >> diseases. > > > > > >> > > > > > > >> > > > > > >> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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