Guest guest Posted June 16, 2007 Report Share Posted June 16, 2007 has pointed out a number of times that autoantibodies are common, and are not generated only in patients experiencing autoimmune diseases. Various proteins are capable of putting the brakes on inflammation. IL-10 is the obvious example, but there are others. So what if the autoantibody that some people generate happens to neutralize one of these " brakes " ? The inflammation might persist unabated, and might perpetuate the production of the original offending autoantibody. Today's offering by Nature suggests that this indeed happens with MS: http://tinyurl.com/yofjda They present data indicating that MS patients, but not control patients, produce antibody against CRYAB, a molecule that inhibits inflammation. They present other data, in mice, indicating the negative impact that this has. If true, this is spectacular. Matt Quote Link to comment Share on other sites More sharing options...
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