off topic elegance

[Guest guest]

Nothing to do with anything but...

" elegance " should not be a scientific term but reserved for people

like Grace . Do we have elegance anymore? I am not serious here -

just expressing one of my pet peeves.

a

>

> There's one sentence in the full text of that paper that deals with

> mechanism. They don't know why CRYAB would work, but they give

> brief speculations. They suggest that the intravenously injected

> CRYAB might enter the CNS and then cross the cell membrane into the

> cell where it could then mediate an anti-inflammatory effect. This

> seems like a tall tale to me. They also suggest that CRYAB might

> neutralize the anti-CRYAB autoantibodies, which I think is the more

> likely scenario. But it looks to me like CRYAB is an INTRAcellular

> protein. So how would autoantibody enter the cell in order to bind

> CRYAB? It seems to me that the most likely explaination is that

the

> anti-CRYAB autoantibodies are cross-reacting with some unidentified

> EXTRAcellular protein and that is what mediates disease whereas the

> binding of CRYAB itself by these antibodies is not mediating

> disease. But that takes all the elegance out of this paper. What

> looked beautiful about this paper at first was the idea that the

> immune system might be neutralizing an anti-inflammatory protein.

> This would go along way towards accounting for " autoimmunity "

> itself. Alas, I don't think this paper has moved us one step

closer

> to understanding this Big Question (i.e., why would the immune

> system become autoaggressive for protracted periods?).

>

> CRYAB is not available commercially, and I doubt that intravenously

> injected CRYAB has a general anti-inflammatory effect anyway. I

> think that if this works at all, it works by complexing anti-CRYAB

> antibody and that might be therapeutic only for MS (if that).

>

> Matt

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> > But I'm still interested in the anti-inflammatory role CRYAB

> might have (I'm just scared that not taking enough would just make

> things worse).

> >

> > I'd like to find some antiinflammatory alternative. Otherwise,

> Benicar's starting to look good to me again because of these

> frequent migraines that have come back. And I really don't want to

> go there as I feel that the Benicar definitely did something to my

> leg muscles that I've slowly recovered from and don't want to

> revisit. But its anti-inflammatory effects were so remarkable for

> me.

>

> >

> > penny

> >

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