Re: CFS Linked to Gene *expression*

[Guest guest]

> Chronic Fatigue Syndrome Linked to Genes, Study Says (Update1)

>

> Thirty-five of those genes were [*]expressed[*] differently in those

who recovered promptly from the illness to those who went on to suffer

months of physical and or mental weakness.

The author of the article has confused two different things. The

sentence " disease X is linked to genes " has many possible literal

interpretations, but in practice this kind of use of the word " genes "

always means the DNA sequence. But the study being summarized isn't

about the gene sequence, it's about the gene expression: the rate at

which RNA and/or proteins are produced from the gene.

Now, the sequence can affect the expression - but so can lots of other

things, such as inflammation.

[Guest guest]

> Now, the sequence can affect the expression - but so can lots of other

> things, such as inflammation.

E.g. - I have a cold; my identical twin doesn't. He and I have

identical sequences in our IFNg genes, and in all our other genes. You

would say " our genes are exactly the same. "

But I am expressing probably 10 to 1000x more IFNg RNA and IFNg

protein than he is, because I have a cold. Certain pieces of the virus

fit into my TLR proteins and trun them on, they go turn on other

proteins, and eventually some final protein is caused to bind to my

DNA near the IFNg sequence, and the final protein causes RNA

transcriptase to come in and make lots more IFNg RNA than it otherwise

would.

Or something like that. I kind of made that up. That is one way that

expression regulation can work but there are some other ways, and I'm

not sure which one(s) control IFNg.

[Guest guest]

Nicely explained .Thankyou

>

>

> > Chronic Fatigue Syndrome Linked to Genes, Study Says (Update1)

> >

> > Thirty-five of those genes were [*]expressed[*] differently in

those

> who recovered promptly from the illness to those who went on to

suffer

> months of physical and or mental weakness.

>

> The author of the article has confused two different things. The

> sentence " disease X is linked to genes " has many possible literal

> interpretations, but in practice this kind of use of the

word " genes "

> always means the DNA sequence. But the study being summarized isn't

> about the gene sequence, it's about the gene expression: the rate at

> which RNA and/or proteins are produced from the gene.

>

> Now, the sequence can affect the expression - but so can lots of

other

> things, such as inflammation.

>

[Guest guest]

It's good to see that you've really taken all this stuff in..

>

>

> > Now, the sequence can affect the expression - but so can lots of

other

> > things, such as inflammation.

>

>

> E.g. - I have a cold; my identical twin doesn't. He and I have

> identical sequences in our IFNg genes, and in all our other genes.

You

> would say " our genes are exactly the same. "

>

> But I am expressing probably 10 to 1000x more IFNg RNA and IFNg

> protein than he is, because I have a cold. Certain pieces of the

virus

> fit into my TLR proteins and trun them on, they go turn on other

> proteins, and eventually some final protein is caused to bind to my

> DNA near the IFNg sequence, and the final protein causes RNA

> transcriptase to come in and make lots more IFNg RNA than it

otherwise

> would.

>

> Or something like that. I kind of made that up. That is one way that

> expression regulation can work but there are some other ways, and

I'm

> not sure which one(s) control IFNg.

>

[Guest guest]

It's good to see that you've really taken all this stuff in..

>

>

> > Now, the sequence can affect the expression - but so can lots of

other

> > things, such as inflammation.

>

>

> E.g. - I have a cold; my identical twin doesn't. He and I have

> identical sequences in our IFNg genes, and in all our other genes.

You

> would say " our genes are exactly the same. "

>

> But I am expressing probably 10 to 1000x more IFNg RNA and IFNg

> protein than he is, because I have a cold. Certain pieces of the

virus

> fit into my TLR proteins and trun them on, they go turn on other

> proteins, and eventually some final protein is caused to bind to my

> DNA near the IFNg sequence, and the final protein causes RNA

> transcriptase to come in and make lots more IFNg RNA than it

otherwise

> would.

>

> Or something like that. I kind of made that up. That is one way that

> expression regulation can work but there are some other ways, and

I'm

> not sure which one(s) control IFNg.

>