Valkion and hypercoagulability

[Guest guest]

Hi all,

I'm hoping to see my son's clotty blood numbers get better after

starting valkion. Did a quick google search and found this paper:

http://lib.bioinfo.pl/pmid:10704657 Quote from the abstract at the end.

My son has/had high: Alpha2 antiplasmin, antithrombin III, Factor II

Assay, Protein C activity and prothrombin fragment 1+2. The last one

was freaky high 500x ref.

I'm not sure now if I want " antithrombotic agent " effect, since his

antithrombin levels are already elevated. I'm just not sure how to

take this information. Going to send it to Dr S and see what she

thinks. Anyone have uber knowledge of coagulation factors to share

with me?

I'm going to get another set of tests run (the above were from april)

to see where he's at right now. Got to get doctors talking together on

this before he starts using the valkion, because I'm a bit out of my

depth here.

Do you think DK would take a call from another doc with questions

about valkion and clotting disorders?

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Singlet oxygen inactivates fibrinogen, factor V, factor VIII, factor

X, and platelet aggregation of human blood.

Quote:

Therefore, the oxidant here involved has reaction characteristics of

singlet oxygen (1O(2)), a nonradical, excited (i.e., light-emitting)

oxidant. The hemostasis factors sensible to oxidation might dispose of

oxidizable, for their function critical, methionine or cysteine

residues. In conclusion, blood coagulation factors I, V, VIII, X and

thrombocytes are sensible to nonradical oxidants of activated

phagocytes. Via 1O(2) generation, polymorphonuclear leukocytes can

generate a local pericellular zone of anticoagulation. The data

suggest that the cell signal 1O(2) in physiological amounts is an

antithrombotic agent.