Niacinamide and inflammation, infection, ACA and GA- ERIC

[Guest guest]

This ties in with your SLE posts, read on :

GA= Granuloma Annulare, ACA = Atrophica Chronica Acrodermis

Well- I had my Derma appointment in Dartmouth and even though I went

in there with a fairly bad attitude, the guy (about 35 years old)

handled me fine- even when I said " I just paid $250.00 to find out

what I already knew " .

Bottom line- he agrees that what I have is GA (umbrella descriptor)

and probably ACA (specifically) and that it's the result of a prior

infection of either TB, Rickettsia or Lyme and there is no " standard "

treatment.

Off-the grid- he prescribed niacinamide (1500mg daily) for 30 days -

which I'm going to try. Prescription hasn't arrived yet... my

insurance for drugs is MEDCO- mail order.

He said it works about 50% of the time- mechanism unknown.

It's worth a shot, I'm going to try it- as long as my liver stay OK-

supposed to be very low toxicity level for this form.:

references:

1- MODULATES APOPTOSIS

Traister A, Breitman I, Bar-Lev E, Zvibel I, Harel A, Halpern Z, Oren

R.

Related Articles, Links

Nicotinamide induces apoptosis and reduces collagen I and pro-

inflammatory cytokines expression in rat hepatic stellate cells.

Scand J Gastroenterol. 2005 Oct;40(10):1226-34.

PMID: 16165703 [PubMed - indexed for MEDLINE]

REFERENCE #2

Ungerstedt JS, Blomback M, Soderstrom T.

Related Articles, Links

Nicotinamide is a potent inhibitor of proinflammatory cytokines.

Clin Exp Immunol. 2003 Jan;131(1):48-52.

PMID: 12519385 [PubMed - indexed for MEDLINE]