Guest guest Posted June 8, 2007 Report Share Posted June 8, 2007 This is some enormous new disease loci study covering seven common diseases... 2-3,000 individuals in each group. I don't know if that makes it the biggest study of it's kind for some of these diseases - but I'm guessing so, since 50 labs worked on this cooperative. I'm posting it for Tony... " [...] Case-control comparisons identified 24 independent association signals at P < 5e-7: 1 in bipolar disorder, 1 in coronary artery disease, 9 in Crohn's disease, 3 in rheumatoid arthritis, 7 in type 1 diabetes and 3 in type 2 diabetes. [...] We observed association at many previously identified loci, and found compelling evidence that some loci confer risk for more than one of the diseases studied. [...] The importance of appropriately large samples was confirmed by the modest effect sizes observed at most loci identified. " http://www.nature.com/nature/journal/v447/n7145/abs/nature05911.html Haha, you'll like that last sentence, Tony. Modest effect sizes. Sounds like no one gene makes a real big difference in any of these diseases. I don't think that rules out the possibility that some of them could be autoimmune diseases (in some stronger or weaker sense), as there are sooo many genes that can influence thresholds for loss of self-tolerance. But it does tend to make it seem more likely that something big is missing in the ideas most people have of these diseases. Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.