Antimicrobials that cross BB

[Guest guest]

I am gathering more info. I put it on my personal blog so I dont forget.

I am looking for a list of antimicrobials that cross the BBB. That can

be for any organism we are up against. I would love it if you can pass

on what you know.

Borellia: allicin (I think)

Bartonella (does BBB matter?):

Babesia (does BBB matter?):

and so on.

I'll be happy to put it all together and put in the files here is you

all would find that helpful.

I'll be looking fo cysts busters next and will organize that too.

Thank you,

Robin

[Guest guest]

I find MMS does the trick in passing BBB and being very effective.

I am gathering more info. I put it on my personal blog so I dont forget.

I am looking for a list of antimicrobials that cross the BBB. That can

be for any organism we are up against. I would love it if you can pass

on what you know.

Borellia: allicin (I think)

Bartonella (does BBB matter?):

Babesia (does BBB matter?):

and so on.

I'll be happy to put it all together and put in the files here is you

all would find that helpful.

I'll be looking fo cysts busters next and will organize that too.

Thank you,

Robin

[Guest guest]

Robin:

It's wonderful that you are putting together some info. for us. The

whole BBB thing is awkward to me since most have leaky guts. Thus, I

think most of us have BBB's that are not keeping things out well. I

also wonder if tinctures are in a form that crosses BBB or if things

that dissolve in the mouth cross the BBB. So, the situation is

complicated, not just the item, but also the form, the person's

health state, etc. I have also heard that things can not be absorbed

unless other things are present, like Turmeric is suppose to have a

fat present, and calcium is the never ending battle of having to have

several other nutrients for it to be metabolized correctly. I am

sorry if I am making things complicated. I think all organisms are

able to cross the BBB, but some much more likely than others. Thus,

the situation is complicated. I know that I personally am interested

in what kills Bartonella. I have tried a few things, but I am still

looking for something more effective. Sometimes I wonder if

Bartonella should be more in the spotlight than it is. So far things

I have seen that are reported to kill it, have to be in high doses

for long periods of time, costing quite a bit of money. I wonder if

there is something effective that can be more affordable, that can

work in lower doses.

Love and prayers,

Heidi N

>

> > I am gathering more info. I put it on my personal blog so I

dont forget.

> >

> > I am looking for a list of antimicrobials that cross the BBB.

That can

> > be for any organism we are up against. I would love it if you can

pass

> > on what you know.

> >

> > Borellia: allicin (I think)

> > Bartonella (does BBB matter?):

> > Babesia (does BBB matter?):

> > and so on.

> >

> > I'll be happy to put it all together and put in the files here is

you

> > all would find that helpful.

> >

> > I'll be looking fo cysts busters next and will organize that too.

> >

> > Thank you,

> >

> > Robin

> >

> >

> >

>

[Guest guest]

I know minocin crosses the BBB because of the neurological herx. I

added in art to zith then had also a hard neurological herx.. was it

just the zith? I have terrible tummy problems and sky high IgG

allergies to all foods, which suggests leaky gut. I probably have

leaky brain as well.

I am looking first for standard alternatives (and allopathics for

that matter which I think are mino, doxy, zith) that cross that

barrier for sure. I'll google too.

I think I read that high dose allicin does as well.

Thats interesting regarding the absorption factor.

Have you tried clove for bartonella?

The more I am reading this interesting blog by an ILADS MD, the more

I am seeing how experimental this is and how personal it is per

patient/person. This is really an art. I do want a list that is more

or less " for sure " and I want to add about the nuances. At the nuance

point, I think its even more going to be a personal thing. I know the

mino and zith hit me hard. I think the art might have and might be

known for that.

The thing about the blog I am reading, the doc is allopathic but

question a lot out of the ILADS box. Very interesting... subjects

such as the possiblity that drugs for babesia could be hitting lyme.

Thank you, Heidi.

Robin

> >

> > > I am gathering more info. I put it on my personal blog so I

> dont forget.

> > >

> > > I am looking for a list of antimicrobials that cross the BBB.

> That can

> > > be for any organism we are up against. I would love it if you

can

> pass

> > > on what you know.

> > >

> > > Borellia: allicin (I think)

> > > Bartonella (does BBB matter?):

> > > Babesia (does BBB matter?):

> > > and so on.

> > >

> > > I'll be happy to put it all together and put in the files here

is

> you

> > > all would find that helpful.

> > >

> > > I'll be looking fo cysts busters next and will organize that

too.

> > >

> > > Thank you,

> > >

> > > Robin

> > >

> > >

> > >

> >

>

[Guest guest]

this is an interesting concept:

The role of the newer macrolides in the treatment of Lyme

Disease needs further assessment. Erythromycin has been regarded

as ineffective, despite its good in vitro sensitivities.

Azithromycin has been reported to be less effective in the

treatment of early Lyme Disease than amoxicillin (21). Some

physicians use clarithromycin and azithromycin in higher dosages

and for longer periods of time, but there have been no reports of

greater success with these drugs than with the tetracyclines or

beta-lactams. In our experience, all macrolides are effective

when combined with a lysosomotropic agent, especially

hydroxychloroquine(see below)(10).

In evaluating the possible factors, it would appear that

antibiotics that can achieve intracellular concentrations and

activity are the most efficacious drugs. The results of studies in

Klempner's laboratory using a tissue culture model of borrelia

infection demonstrated that ceftriaxone was incapable of eradicating

intracellular organisms (17); similar experiments in Raoult's

laboratory using an endothelial cell model

demonstrated that tetracycline and erythromycin were effective,

but beta lactam antibiotics were not (3). These results are in line

with our experience that the tetracyclines and macrolides achieve the

greatest success.

In contrast to beta lactams, antibiotics of the tetracycline and

macrolide classes are capable of good intracellular penetration.

Experience with the macrolide antibiotics has been disappointing,

however, when compared with

its in vitro activities against the Lyme borreliae, and with the

established efficacy of macrolides against other intracellular

parasites such as chlamydia, legionella, mycobacterium-avium

intracellulare, and toxoplasma. If, though, the Lyme borreliae reside

in intracellular vesicles that are acidic, the macrolides' activity

would be sharply decreased at the lower pH.

This is in contrast to the tetracyclines, which are active at acid

pH; even

so, the activity of doxycycline was shown to be further increased by

increasing the pH. In a tissue culture model of ehrlichia infection,

the use of lysosomotropic agents such as amantidine, NH4Cl, and

chloroquine increased the killing of intracellular organisms by

doxycycline (22).

Based on those studies, and the hypothesis that late Lyme Disease

symptoms are due to persisting intracellular infection, we have been

successfully treating patients using the combination of a macrolide

and hydroxychloroquine (10).

As regards " CNS " disease, there is no evidence that ceftriaxone

is more successful than either the tetracyclines or the combination

of macrolide and hydroxychloroquine; if our presumption that the

pathogenesis of the disease involves the localization of the borrelia

to the endothelial cells of the blood vessels serving the nervous

system or to glial or neural

cells is correct, then one would not need to have a drug that can

cross the blood-brain barrier to be effective. Indeed, the

tetracyclines can cross the blood-brain barrier to some extent, and

were used when initially introduced into clinical medicine for the

treatment of meningitis, with some success.

Macrolide antibiotics do not cross the blood-brain barrier, but have

been

effective in treating other CNS infections (e.g., toxoplasmosis), and

in our experience have been effective in reversing the

neuropsychiatric symptoms and signs (eg SPECT scans) of Lyme Disease

(10). With regard to the issue of bactericidal vs bacteristatic

effects, any such effect in vivo has not been demonstrated.

Finally, there have been no reports showing any change in antibiotic

resistance patterns during the course of treatment. Ultimately, the

determination of efficacy of therapy depends on the clinical

response.

clinical response.

http://www.prohealth.com/library/showarticle.cfm?id=3579 & t=CFIDS_FM