looks interesting

[Guest guest]

I believe cancer patients should concentrate more on natural healing foods than

man made synthetic vitamins and supplements. (even the so called natural ones).

I think true healing comes from lifestyle change. Eating more natural foods

that your body actually knows what to do with. I don't believe your body knows

what to do with synthetic vitamins and supplements.

M.

[Guest guest]

Amen

________________________________

On Behalf Of Lantz Melina

I believe cancer patients should concentrate more on natural healing

foods than man made synthetic vitamins and supplements. (even the so

called natural ones). I think true healing comes from lifestyle change.

Eating more natural foods that your body actually knows what to do with. I don't

believe your body knows what to do with synthetic vitamins and supplements.

M.

[Guest guest]

This seems like it might bear some relationship to JJ ' recent

findings about a final common pathway of cell death caused by cidal

abx, discussed here on the thread " ipes! yo! blimey! good morning,

Vietnam! hold the phone! wait! hang on! "

----------------------------------------------------

J Biol Chem. 2008 Jan 15 [Epub ahead of print]

Nitric oxide evokes an adaptive response to oxidative stress by

arresting respiration.

Husain M, Bourret TJ, McCollister BD, -Carson J, Laughlin J,

Vazquez- A.

Microbiology, University of Colorado Health Sciences Center,

Aurora, CO 80010.

Aerobic metabolism generates biologically challenging reactive

oxygen species (ROS) by the endogenous autooxidation of components of

the electron transport chain (ETC). Basal levels of oxidative stress

can dramatically rise upon activation of the NADPH oxidase-dependent

respiratory burst. To minimize ROS toxicity, prokaryotic and

eukaryotic organisms express a battery of low-molecular-weight thiol

scavengers, a legion of detoxifying catalases, peroxidases and

superoxide dismutases, as well as a variety of repair systems. We

present herein blockage of bacterial respiration as a novel strategy

that helps the intracellular pathogen Salmonella survive extreme

oxidative stress conditions. A Salmonella strain bearing mutations in

complex I NADH dehydrogenases is refractory to the early NADPH

oxidase-dependent antimicrobial activity of IFNg-activated

macrophages. The ability of NADH-rich, complex I-deficient Salmonella

to survive oxidative stress is associated with resistance to

peroxynitrite (ONOO-) and hydrogen peroxide (H2O2). Inhibition of

respiration with nitric oxide (NO) also triggered a protective

adaptive response against oxidative stress. Expression of the NDH-II

dehydrogenase decreases NADH levels, thereby abrogating resistance of

NO-adapted Salmonella to H2O2. NADH antagonizes hydroxyl radical (OH*)

generated in classical Fenton chemistry or spontaneous decomposition

of peroxynitrious acid (ONOOH), while fueling AhpCF

alkylhydroperoxidase. Together, these findings identify the

accumulation of NADH following the NO-mediated inhibition of

Salmonella's ETC as a novel antioxidant strategy. NO-dependent

respiratory arrest may help mitochondria and a plethora of organisms

cope with oxidative stress engendered in situations as diverse as

aerobic respiration, ischemia reperfusion and inflammation.

PMID: 18198179 [PubMed - as supplied by publisher]