Guest guest Posted August 24, 2007 Report Share Posted August 24, 2007 Here's something related to what I said before: " Since the establishment of standard protocols for rodent carcinogenicity studies in 1960s, there has been a steady decline in survival of the commonly used laboratory rats, including both inbred stocks [...] and an outbread stock like the Fischer-344. Two primary factors appear responsible [...]: breeder selection for more rapid growth and fecundity and ad libitum feeding with a resultant increase in adult body weight [ref]. " [PDF] INFLUENCE OF ORIGIN OR CONTROLLED FEEDING ON LONGEVITY OF SPRAGUE ... File Format: PDF/Adobe Acrobat Two-year survival offemale Sprague-Dawley (SD) rats obtained from. four different sources: River International Standard (IS) rats, Hollister, ... taylorandfrancis.metapress.com/index/UD76WRJ2R363AM2W.pdf - Similar pages Quote Link to comment Share on other sites More sharing options...
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