Guest guest Posted December 21, 2007 Report Share Posted December 21, 2007 :I have been reading about MMS on another group as a way to eliminate bacteria and viruses, does any one here use it or have any experience with it? Thanks for any info.! > > > > > >> doallowed us to make a number ofabout human UTIs, but at the end of the day, we felt it > > was critical to show this in humans, and now we've done just that, " > > says senior author J. Hultgren, Ph.D., the Helen L. Stoever > > Professor of Molecular Microbiology at the School of Medicine. > > > > The results appear in the December issue of Public Library of > Science > > Medicine. > > > > Fully understanding what bacteria do in the bladder is critical to > > developing better diagnoses and treatments for UTIs, Hultgren says. percent to 90 percent of UTIs, which occur mainly in women and are > one> of the most common bacterial infections in the United States. > > Scientists estimate that more than half of all women will > experience a > > UTI in their lifetimes, and recurrent UTIs will affect 20 percent to > > 40 percent of those patients. > > > > " Recurrence is one of the biggest problems of UTIs, " says Hultgren. > > " Even though we have treatments that eliminate the acute symptoms, > the > > in so many women tells me that sepsis. But after Hultgren first > > invade bladder cells in 1998, he later found evidence in his animal > > model that bacteria could establish residence inside those cells. He > > showed that this process involved several behavioral changes that > > allow the bacteria to form cooperative communities known as > biofilms. > > By working together, bacteria in biofilms build themselves into > > structures that are more firmly anchored in infected cells and are > > more resistant to immune system assaults and antibiotic treatments. > > > > To prove that the model correlates with human infections, Rosen led > an > > analysis of human urine samples sent from a clinic at the University > > of Washington in Seattle. The 100 patients who gave samples were > > either suffering from an active, symptomatic infection or had > > previously suffered infections. Researchers analyzing the specimens > > were not told which group of patients individual specimens had come > from. > > > > Using light and electron microscopy and immunofluoresence, > scientists > > found signs of bladder cell infection in a significant portion of > the > > samples from patients with active UTIs. These included cells > enlarged > > by bacterial infection and shed from the lining of the bladder. > > > > In addition, Hultgren's experiments had previously suggested that > some > > bacteria progress to a filament-like shape when exiting out of the > > biofilm. Rosen was able to identify bacteria with this filamentous > > morphology in 41 percent of samples from patients with symptomatic > UTIs. > > > > Neither indicator was detected in urine from women who did not have > > active infections. This was anticipated: Hultgren's animal model > work > > suggests that when women are between episodes of symptomatic > > infection, intracellular E. coli may be in dormant phases where > there > > would be little cause for bacteria or the cells they infect to be > shed > > into the urine. > > > > Further research is needed to determine if the infection indicators > > Rosen detected in urine samples from symptomatic women are signs of > > increased risk of recurrent infection. But looking for those signs > > using immunofluorescent staining and a variety of microscopy methods > > is unlikely to be practical on a widespread clinical basis. So to > > follow up, Hultgren plans a search for biochemical indicators linked > > to higher risk of recurrent UTIs and of infection spreading to a > > patient's kidneys. His lab also continues to be involved in many > > different efforts to develop new vaccines and treatments. > > > > " What we're learning about how bacteria behave in the bladder may > also > > have application to other chronic, treatment-resistant infections > such > > as sinus infections and ear infections, " he says. " We're > increasingly > > starting to realize that biofilm formation is generally an important > > strategy bacteria use to evade host responses and antibiotic > > therapies. Attacking biofilms is going to be a really important > > approach as we enter a new era of fighting infectious diseases. " > > > Quote Link to comment Share on other sites More sharing options...
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