bacterial persistence in leprosy

[Guest guest]

I was not real aware that this happened in leprosy.

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Int J Lepr Other Mycobact Dis. 1981 Jun;49(2):205-17.Links

Bacterial persistence in leprosy.

Toman K.

Bacterial persistence is the capability of microorganisms to

survive in the host despite adequate antimicrobial treatment. This is

a general phenomenon and has been observed during infection with a

number of organisms. The subject is reviewed in relation to the

treatment of leprosy. The presence of persisters in the large

bacterial populations that exist in patients with lepromatous leprosy

is not surprising. It is unlikely that in the near future a new drug

or combination of drugs will be found that is capable of eradicating

persisting M. leprae. It may be useful, nevertheless, to reconsider

whether the sporadic demonstration of viable, drug-susceptible

organisms after antimicrobial treatment of variable duration and

efficacy warrants a policy of life long chemotherapy in lepromatous

leprosy.

PMID: 6792087 [PubMed - indexed for MEDLINE]

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Indian J Lepr. 1997 Oct-Dec;69(4):385-93.Links

Understanding the phenomenon of persistence in mycobacterial

infections.

Gupta UD, Katoch VM.

Experimental Leprosy Laboratory, Central JALMA Institute for

Leprosy (ICMR), Tajganj, Agra.

Persistence of live organisms despite chemotherapy for long

periods is a significant problem in both leprosy and tuberculosis. The

consequence of this persistence is varying rates of relapses which

undermine the success of treatment. The mechanisms of the dormancy are

ill-understood, and as explanation a switch over to alternate modes of

metabolism such as glyoxylate bypass and other shunts has been

suggested. This presentation reviews the information available on this

aspect. In-depth studies by designing and investigating model

system(s) using molecular genetic approaches may help in gaining

better understanding of the mechanisms of dormancy and persistence in

mycobacterial infections and devising appropriate strategies and tools

for the better management of these complications.

PMID: 9474514 [PubMed - indexed for MEDLINE]

[Guest guest]

The Human body has to be in pristine condition to enable complete

eradication of many infections. I suppose the organisms that

congregate in and around the skeleton, would be prime candidates for

persisting...Remembering also that strepo throat infections are never

eradicated just treated for the short periods everytime they flare..

tony

>

>

> I was not real aware that this happened in leprosy.

>

>

> ---------------------------------------------

>

> Int J Lepr Other Mycobact Dis. 1981 Jun;49(2):205-17.Links

> Bacterial persistence in leprosy.

> Toman K.

>

> Bacterial persistence is the capability of microorganisms to

> survive in the host despite adequate antimicrobial treatment. This

is

> a general phenomenon and has been observed during infection with a

> number of organisms. The subject is reviewed in relation to the

> treatment of leprosy. The presence of persisters in the large

> bacterial populations that exist in patients with lepromatous

leprosy

> is not surprising. It is unlikely that in the near future a new drug

> or combination of drugs will be found that is capable of eradicating

> persisting M. leprae. It may be useful, nevertheless, to reconsider

> whether the sporadic demonstration of viable, drug-susceptible

> organisms after antimicrobial treatment of variable duration and

> efficacy warrants a policy of life long chemotherapy in lepromatous

> leprosy.

> PMID: 6792087 [PubMed - indexed for MEDLINE]

>

>

> --------------------------------------------------------

>

>

> Indian J Lepr. 1997 Oct-Dec;69(4):385-93.Links

> Understanding the phenomenon of persistence in mycobacterial

> infections.

> Gupta UD, Katoch VM.

>

> Experimental Leprosy Laboratory, Central JALMA Institute for

> Leprosy (ICMR), Tajganj, Agra.

>

> Persistence of live organisms despite chemotherapy for long

> periods is a significant problem in both leprosy and tuberculosis.

The

> consequence of this persistence is varying rates of relapses which

> undermine the success of treatment. The mechanisms of the dormancy

are

> ill-understood, and as explanation a switch over to alternate modes

of

> metabolism such as glyoxylate bypass and other shunts has been

> suggested. This presentation reviews the information available on

this

> aspect. In-depth studies by designing and investigating model

> system(s) using molecular genetic approaches may help in gaining

> better understanding of the mechanisms of dormancy and persistence

in

> mycobacterial infections and devising appropriate strategies and

tools

> for the better management of these complications.

>

> PMID: 9474514 [PubMed - indexed for MEDLINE]

>