What happens when amphotericin B stops working?

[Guest guest]

Okay, my bugs seem to have won again. I think I had a good run with the

amp B compounded nasal spray (not really sure as I'm also on

ketokonazole) but it seems pretty apparent that the Amp B is doing

nothing now. To be honest, I think the steroid in the nasal spray gave

me more relief (from inflammatory symptoms) than anything else. But the

side effects of even that miniscule amount of steroid are getting to me

and I'd like to find some kind of alternative.

So what happens if/when amp. B stops working? Rotate it up and hope the

bugs will become susceptible again? Or am I totally screwed? Or do I

not have any fungal stuff for it to be effective against? The main

reason I'm saying it has " stopped working " is I don't notice any

difference with or without it. Pretty hard to tell under the

circumstances anyway with the lack of any positive fungal

identification.

Oh, plus my migraines are back in a big way which are definitely sinus

infection related. I can't use the dehumidifier due to the heat of

summer (besides, my bugs adapted to the dehumidifier after a few weeks

as well). The only way I can prevent the migraines now is to sleep

sitting up in bed, which means I'm getting very poor quality sleep. If

I lay down at all, I will wake up with a migraine on whichever side my

head is turned. :-(

I continue to notice a difference in my pain levels with and without

the steroid in the spray, so that sucks. But the other ingredients (amp

b and gentamycin) seem to have no effect at all.

Those of you who've had success with Amp. B, how do you take it and

what has been your experience with resistance?

penny