RE: Re: News on Fungal Sinusitis

[Guest guest]

Tim , IgG antibodies against aspergillus in the blood is an indication

that you either have an ongoing systemic  infection or have suffered an infection in the past  ..I find it strange that you have such a

dramatic result without anyone explaining the possible consequences of the

result ..If you feel ill , which I assume you do ,an ongoing infection is likely

…..search on IgG and test  

Contact the group below to be included in the newsletter …they are

reputed to be the world leading authority on Aspergillus infections ..i was a

patient at one time to Professor Denning  who is head of the organisation ..that’s another story as they say

aspergillus@...

 

Aspergillus Newsletter

eNewsletter: March 7, 2008

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Aspergillus website 10th

anniversary Symposium

This year marks the tenth year that the

Aspergillus website has been running and we marked the occasion with a

symposium on the 3rd March 2008 for sponsors, invited friends and patients

along with Trustees of both the Fungal Research Trust and the Aspergillus

Trust.

Talks from Prof. Denning (Chief medical editor) and

website team members Dr Graham Atherton and Dr Bartholomew were

attended by over 60 participants in a very

successful event.

Statistics

presented by Graham Atherton showed that the Aspergillus Website is

currently reaching record levels of use with well over 420 000 page

requests in January 2008 and over two thirds of the countries of the world

using the website during the average month with more than 26 000 individual

computers accessing the website.!

This month

The outstanding website development this month is the

extensive update of the treatment article for Invasive

Pulmonary Aspergillosis (IPA) by Professor Denning. Using the latest

guidelines and incorporating the latest drugs it is definitely a 'must read'.

The Aspergillus Website and the Fungal

Research Trust provided most of the materials and two

interviews for the recent nationwide story on 2 cases of neonatal

aspergillosis at Salford Royal Hospital in Manchester - read about it in

the Aspergillus

blog.

Latest News and Articles

There have been 25 additions to the articles

section. Two of these have used green fluorescence protein as a visual

marker for studies with Aspergillus. We have picked out these and a few of

the other highlights here:

Development of a GFP-Expressing Aspergillus flavus Strain

to Study Fungal Invasion, Colonization, and

Resistance

in Cottonseed

Green fluorescent protein (GFP) glows bright green and can be attached to

many cells and subcellular components, including fungal cells and cell

components. In this study the entire fungus (Aspergillus flavus) glowed

brightly, so the research team were able to follow the ingress of fungal

conidia (spores) into cotton seeds, identifying the route of entry of the

spores into the plant. They were than able to see where the fungal growth

took place as the new fungal hyphae also glowed bright green, and they even

claim that they could see some secondary metablite production by the fungus

deep within plant tissues.

This glowing aspergillus strain could prove to be a valuable

tool when investigating pathogen invasion and host resistance.

GFP-tagged

expression analysis revealed that some histidine kinases of Aspergillus

nidulans show temporally and spatially different expression during the life

cycle.

In this study GFP was used to follow the expression of

several histidine kinase (HK) genes - the GFP was fused to the mechanisms

that control HK so that it would be switched on whenever the HK was

switched on.

HK is postulated to be an important gene for controlling

gene expression but there are many of these genes in each cell - A.

nidulans has at least 15. This study looks at when the GFP-fused genes are

expressed over time during the cell cycle, at where the genes are expressed

within the fungus (spacial arrangement) and at gene expression during

sexual differentiation. Some differences were detected so there is some

evidence that although each HK gene carries out a similar function, it does

it at different times or in distinct subcellular locations.

Fungus

balls of the paranasal sinuses: a review

A review of the clinical, radiological, and pathological presentation of

the fungus ball of the paranasal sinuses as well as the surgical management

with emphasis on the transnasal endoscopic approach.

Black olives as substrate for Aspergillus parasiticus growth and

aflatoxin B1 production

A short experiment that demonstrated black olives do not make a good

substrate for the growth of Aspergillus

parasiticus, a known producer of aflatoxin

B1.

Diagnosis

Several new articles have been added including : " Diagnosis

of invasive septate mold infections. A correlation of microbiological

culture and histologic or cytologic examination " and ‘Deep’

white superficial onychomycosis due to molds

Educational

34 slide presentations from the 3rd

Advances Against Aspergillosis meeting and 8 slide presentations from the

3rd Trends in Medical Mycology meeting are available for download in the slides section.

Authors include Samson, Johan Maertens, Bill Nierman and

Denning.

Medical Images

In

the image library in the " other " section there are three CT scans

showing non-union

of the sternum after an aortic valve replacement, as a result of local

Aspergillus fumigatus infection. The patient had a sternal wound and

osteomyelitis after valve replacement.

Images of a patient with severe

kyphoscoliosis caused by more than 40 years of prednisolone for ABPA

and asthma can be seen in the allergic

aspergillosis section of the image library.

Genomics

The genomics section of the website is about to have a large

addition which willl cause large scale changes for that and other sections.

The CADRE website is to

become closely interlinked with the Aspergillus website and in particular

the metabolite information - it currently contains complete genomes for

three Aspergillus species (fumigatus, oryzae and nidulans) with more to

come. The project should be complete towards the end of this year.

Searching the website

We now have a dedicated Google Search Appliance for this

website. This means you can search the Aspergillus website using Google and

it will include nearly all documents on the website (pdf, doc, ppt, html,

php etc). and will include parts of the secure sections and eventually

index images - a big improvement on earlier search facilites. Try it out here.

HonCode

Health

on the Net Foundation (HonCode)

are the formost accrediation service for health-oriented websites. The

Aspergillus website has been accredited since 1999 and this has once again

been reaffirmed after the latest review in August 2007

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What is RSS and how do I use it? Get help here.

Thanks for reading!

Visit our website again soon.

The Aspergillus Team.

©2007 Fungal Research Trust, PO

Box 482, Macclesfield, Cheshire SK10 9AR, UK.

The Aspergillus Website is wholly funded by

the Fungal Research Trust (FRT), a registered UK charity. To get more

information on the work this charity do, go to their website at http://www.fungalresearchtrust.org/Press.html.

They are well worth your support.

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-----Original

Message-----

From:

infections

[mailto:infections ]On Behalf Of candtcampbell@...

Sent: 13 March 2008 17:29

To:

infections

Subject:

[infections] Re: News on Fungal Sinusitis

Speaking of fungal infections, does

anybody know what my high aspergillus

IgG blood level means? Does it indicate allergy or infection, for

example? If infection, would it be local or systemic?

Tim

[Guest guest]

Tim ,I’m

glad you found the info useful , a syndrome is not a firm diagnosis, syndrome

is just a collection of symptoms the cause of which are not understood. Gene

involvement is a bit of a red herring the rise in sensitivity to fungi has occurred

within a generation ..it simply rules out a genetic cause, you maybe genetically

disposed to be more sensitive than others , but thats neither here nor there

...there is a common external cause, as there is with many up and coming

conditions.

Unfortunately doctors will

avoid treating fungal infections if they can ..testing is a specialist area,

the treatment is long term and open ended ..Lots to trip up the doctor … A

biopsy is considered definitive or microscopy examination for spores in the

blood .you need the good will of a doctor to organise the tests , it doesn’t

look as if you have that at the moment ..I would consider getting the aspergillus’s

group involved , their web site has details of the tests for aspergillus ..Many

of the tests are common to other fungal infections ..metabolites etc; If your doc doesn’t play ball you must find

one that will …hope this helps .. http://www.aspergillus.org.uk/

.. http://www.yeast-candida-infections-uk.co.uk/

-----Original

Message-----

From:

infections

[mailto:infections ]On Behalf Of candtcampbell@...

Sent: 15 March 2008 18:48

To:

infections

Subject:

[infections] Re: News on Fungal Sinusitis

,

Thanks for

your reply. I do feel very ill. What I've been told is that I likely have

" sick building syndrome, " but to my knowledge, SBS is more of an allergy

than an infection. I'm in the USA, and have seen Dr. Shoemaker, who is our best

mold expert. He says I have the genes to be sensitive to mold, but I was

negative on all of his tests, which did not include aspergillus IgG. About 5

years ago, I had a CAT scan that showed an unidentified spot, about 1/4 inch in

diameter on my lung. So I'm quite confused and trying to get this sorted out

without much help from the medical profession. Can you tell me anything more

from your personal experience?

Tim

Tim , IgG

antibodies against aspergillus in the blood is an indication that

you either have an ongoing systemic infection or have suffered an infection

in the past ..I find it strange that you have such a dramatic result

without anyone explaining the possible consequences of the result ..If you

feel ill , which I assume you do ,an ongoing infection is likely …..search

on IgG and test

Contact the group below to be included in the newsletter …they are reputed

to be the world leading authority on Aspergillus infections ..i was a

patient at one time to Professor Denning who is head of the organisation

...that’s another story as they say