Guest guest Posted August 15, 2008 Report Share Posted August 15, 2008 Can 't access pub med. Do you know what the marine natural product is specifically? penny From: <usenethod@...>Subject: [infections] shalom aleicheminfections Date: Thursday, August 14, 2008, 4:25 PM A small molecule derived from a marine natural product with theability to inhibit biofilm formation and also disperse establishedproteobacterial biofilms is presented.PMID: 18368169 SA, Melander C.No AbstractConstruction and screening of a 2-aminoimidazole library identifies asmall molecule capable of inhibiting and dispersing bacterial biofilmsacross order, class, and phylum.Angew Chem Int Ed Engl. 2008;47(28): 5229-31. No abstract available.PMID: 18528836 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 16, 2008 Report Share Posted August 16, 2008 Madam, train your awareness on this notice in a mysterious foreign periodical: http://www.rsc.org/Publishing/Journals/cb/Volume/2008/4/marine_inspira tion_for_biofilm_break_up.asp I have only the North Carolina group's abstracts, not their papers. As best I can tell, they are working on this " oroidin, " isolated from a sponge, and on derivatives thereof. It was discovered a long time ago, but I can't seem to easily learn when its biofilm dispersing properties were discovered. Recently, I'm guessing. This paper delves a little into the ecology. It looks like oroidin saddens a whole variety of different organisms, even fish. Thus the function in the sponge is perfectly unclear. Since sponges are filter feeders, it seems clear that they should have a basically pretty negative attitude about biofilms choking their filter pores. But they also face lots of other ecological problems in their incandescent struggle for life, knowledge, and meaning. And all their problems are ipso facto problems for their dependent bacterial symbionts as well; some products from sponges, etc, are actually made by bacterial symbionts. Sponges: un type vecu... http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6T4R- 48F5G3W- 4 & _user=10 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view=c & _version=1 & _urlVe rsion=0 & _userid=10 & md5=fc693a84dbaa5c02128ab70c8a8ad374 I wonder what is up with oroidin dispersing biofilms " across order, class, and phylum. " Why would lots of different, highly diverse bacteria (perhaps indeed all bacteria?) use the very same code (ie, receptor- " hormone " pair) to signal dispersion? It's very odd since this sets them up to be " hacked " by any organism that exudes oroidin, whereas any bacterium not responsive to oroidin would not be hacked. There are possible reasons for this, I guess. Different bacterial species/strains/whatever might be able to sense different sorts of danger/etc which render it wise to disperse extremely immediately. If these dangers/situations - or more precisely, the signs of them that can be sensed) are extremely diverse - then maybe most species wouldn't evolve to sense most of the dangers, since the selection pressure wouldn't be high enough. But if they all use the same dispersion signal, then a given species can benefit from overhearing all the other species, who sense many sorts of stimuli that the given species cannot sense. However, I think this explanation is of very modest plausibility. As you may recall... DG Davies was supposed to have a molecule with these same properties, 18 months ago, but hasn't published. That's odd. > Can 't access pub med. Do you know what the marine natural product is specifically? > > penny > > A small molecule derived from a marine natural product with the > ability to inhibit biofilm formation and also disperse established > proteobacterial biofilms is presented. > PMID: 18368169 > > SA, Melander C. > No Abstract > Construction and screening of a 2-aminoimidazole library identifies a > small molecule capable of inhibiting and dispersing bacterial biofilms > across order, class, and phylum. > Angew Chem Int Ed Engl. 2008;47(28): 5229-31. No abstract available. > PMID: 18528836 [PubMed - indexed for MEDLINE] > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 17, 2008 Report Share Posted August 17, 2008 And aleichem shalom I don't have time to look into this kind of stuff these days, but it reminds me of Bonnie Bassler's work, profiled recently on PBS's Nova Now. You may already know of her. This seems to be another odd example of inter-species communication: " Instead, Bassler explained, using quorum sensing, the bacteria count themselves and when they reach a sufficiently high number, they all launch their attack simultaneously. This way, the bacteria are more likely to overpower the immune system....Bassler showed that a gene called luxS is required for production of AI-2, and that hundreds of species of bacteria have this gene and use AI-2 to communicate. This work suggests that bacteria have a universal chemical language, a type of " bacterial Esperanto " that they use to talk between species....She was also chosen as the 2004 Inventor of the Year by the New York Intellectual Property Law Association for her idea that interfering with the AI-2 language could form the basis of a new type of broad-spectrum antibiotic. " The fantasy is to make one pill that works against all kinds of bacteria, " she said. " quoted from http://www.hhmi.org/research/investigators/bassler_bio.html Apologies if this has already been discussed. > > > Madam, train your awareness on this notice in a mysterious foreign > periodical: > > http://www.rsc.org/Publishing/Journals/cb/Volume/2008/4/marine_inspir a > tion_for_biofilm_break_up.asp > > I have only the North Carolina group's abstracts, not their papers. > As best I can tell, they are working on this " oroidin, " isolated from > a sponge, and on derivatives thereof. It was discovered a long time > ago, but I can't seem to easily learn when its biofilm dispersing > properties were discovered. Recently, I'm guessing. > > This paper delves a little into the ecology. It looks like oroidin > saddens a whole variety of different organisms, even fish. Thus the > function in the sponge is perfectly unclear. Since sponges are filter > feeders, it seems clear that they should have a basically pretty > negative attitude about biofilms choking their filter pores. But they > also face lots of other ecological problems in their incandescent > struggle for life, knowledge, and meaning. And all their problems are > ipso facto problems for their dependent bacterial symbionts as well; > some products from sponges, etc, are actually made by bacterial > symbionts. Sponges: un type vecu... > > http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6T4R- > 48F5G3W- > 4 & _user=10 & _rdoc=1 & _fmt= & _orig=search & _sort=d & view=c & _version=1 & _urlV e > rsion=0 & _userid=10 & md5=fc693a84dbaa5c02128ab70c8a8ad374 > > I wonder what is up with oroidin dispersing biofilms " across order, > class, and phylum. " Why would lots of different, highly diverse > bacteria (perhaps indeed all bacteria?) use the very same code (ie, > receptor- " hormone " pair) to signal dispersion? It's very odd since > this sets them up to be " hacked " by any organism that exudes oroidin, > whereas any bacterium not responsive to oroidin would not be hacked. > > There are possible reasons for this, I guess. Different bacterial > species/strains/whatever might be able to sense different sorts of > danger/etc which render it wise to disperse extremely immediately. If > these dangers/situations - or more precisely, the signs of them that > can be sensed) are extremely diverse - then maybe most species > wouldn't evolve to sense most of the dangers, since the selection > pressure wouldn't be high enough. But if they all use the same > dispersion signal, then a given species can benefit from overhearing > all the other species, who sense many sorts of stimuli that the given > species cannot sense. However, I think this explanation is of very > modest plausibility. > > As you may recall... DG Davies was supposed to have a molecule with > these same properties, 18 months ago, but hasn't published. That's > odd. > > > > > > Can 't access pub med. Do you know what the marine natural product > is specifically? > > > > penny > > > > > > > > > A small molecule derived from a marine natural product with the > > ability to inhibit biofilm formation and also disperse established > > proteobacterial biofilms is presented. > > PMID: 18368169 > > > > SA, Melander C. > > No Abstract > > Construction and screening of a 2-aminoimidazole library identifies > a > > small molecule capable of inhibiting and dispersing bacterial > biofilms > > across order, class, and phylum. > > Angew Chem Int Ed Engl. 2008;47(28): 5229-31. No abstract available. > > PMID: 18528836 [PubMed - indexed for MEDLINE] > > > Quote Link to comment Share on other sites More sharing options...
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