Re: Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

[Guest guest]

hi barb. please tell your friend that he can be tested for the antibodies to the MLV-related viruses and XMRV at VIP diagnostics. he has to call and order a testing kit. i think the test will cost about $250.

sue

From: egroups1bp <bpeck9191@...>infections Sent: Thu, August 26, 2010 8:35:04 AMSubject: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

I've forwarded all this info to my CFS friend- who is very disabled.I hope now he can find a Doc.. (and he has many) that can get him in a drug trial- or prescribe an anti-viral that may help him..This is BIG news.. especially since the initial news was sort of poo pooed.Barb> > > From: ESME European Society for ME <post@...>> Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients> "ESME European society of ME" <post@...>> Date: Tuesday, August 24, 2010, 12:48 AM> > > >

> > > > > > > > > > ESME IVWZ> KBO: 0817.905.582> > > The long-awaited FDA/NIH study was released yesterday. Four types of MLV-related viruses were found in CFS patients and one healthy blood donor. The team, lead by Harvey Alter of the National Institutes of Health, said their finding adds to evidence that viruses may be linked with the debilitating condition. (CFS)> Read the abstract below or the full article at: http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html> > Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors> Abstract> Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A

recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a> genetically diverse group of MLV-related viruses. The gag and env

sequences from CFS patients were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply. > Source: www.pnas.org> > > News articles about the study: > http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c.html?xid=rss-topstories > http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1 > http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.html > http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue > WPI congratulates Alter and Lo:

> http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823 > > Kind regards > ESME> > > > The European

Society for ME is a non-profit group, operated entirely by volunteers. You can support ESME with a donation by visiting: http://esme-eu.com/donate/category114.html.> > Your donation will go directly to our goals of educating doctors and helping scientists to solve the puzzle of ME/CFS: www.esme-eu.com.> >

[Guest guest]

thanks Sue. This is helpful info. If you have a link, you could add it to our files section.

From: Sue <suebackagain123@...>Subject: Re: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patientsinfections Date: Thursday, August 26, 2010, 6:47 AM

hi barb. please tell your friend that he can be tested for the antibodies to the MLV-related viruses and XMRV at VIP diagnostics. he has to call and order a testing kit. i think the test will cost about $250.

sue

From: egroups1bp <bpeck9191@...>infections Sent: Thu, August 26, 2010 8:35:04 AMSubject: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

I've forwarded all this info to my CFS friend- who is very disabled.I hope now he can find a Doc.. (and he has many) that can get him in a drug trial- or prescribe an anti-viral that may help him..This is BIG news.. especially since the initial news was sort of poo pooed.Barb> > > From: ESME European Society for ME <post@...>> Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients> "ESME European society of ME" <post@...>> Date: Tuesday, August 24, 2010, 12:48

AM> > > > > > > > > > > > > > ESME IVWZ> KBO: 0817.905.582> > > The long-awaited FDA/NIH study was released yesterday. Four types of MLV-related viruses were found in CFS patients and one healthy blood donor. The team, lead by Harvey Alter of the National Institutes of Health, said their finding adds to evidence that viruses may be linked with the debilitating condition. (CFS)> Read the abstract below or the full article at: http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html> > Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors> Abstract> Chronic fatigue syndrome (CFS) is a

serious systemic illness of unknown cause. A recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a> genetically diverse group

of MLV-related viruses. The gag and env sequences from CFS patients were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply. > Source: www.pnas.org> > > News articles about the study: > http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c.html?xid=rss-topstories > http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1 > http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.html > http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue > WPI congratulates Alter and Lo:

> http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823 > > Kind regards > ESME> > > > The European

Society for ME is a non-profit group, operated entirely by volunteers. You can support ESME with a donation by visiting: http://esme-eu.com/donate/category114.html.> > Your donation will go directly to our goals of educating doctors and helping scientists to solve the puzzle of ME/CFS: www.esme-eu.com.> >

[Guest guest]

Hi Penny. I dont know how to add files but here is the link:

http://www.vipdx.com/

From: Penny Houle <pennyhoule@...>infections Sent: Thu, August 26, 2010 11:54:52 PMSubject: Re: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

thanks Sue. This is helpful info. If you have a link, you could add it to our files section.

From: Sue <suebackagain123@...>Subject: Re: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patientsinfections Date: Thursday, August 26, 2010, 6:47 AM

hi barb. please tell your friend that he can be tested for the antibodies to the MLV-related viruses and XMRV at VIP diagnostics. he has to call and order a testing kit. i think the test will cost about $250.

sue

From: egroups1bp <bpeck9191@...>infections Sent: Thu, August 26, 2010 8:35:04 AMSubject: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

I've forwarded all this info to my CFS friend- who is very disabled.I hope now he can find a Doc.. (and he has many) that can get him in a drug trial- or prescribe an anti-viral that may help him..This is BIG news.. especially since the initial news was sort of poo pooed.Barb> > > From: ESME European Society for ME <post@...>> Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients> "ESME European society of ME" <post@...>> Date: Tuesday, August 24, 2010, 12:48 AM> > > > > > >

> > > > > > > ESME IVWZ> KBO: 0817.905.582> > > The long-awaited FDA/NIH study was released yesterday. Four types of MLV-related viruses were found in CFS patients and one healthy blood donor. The team, lead by Harvey Alter of the National Institutes of Health, said their finding adds to evidence that viruses may be linked with the debilitating condition. (CFS)> Read the abstract below or the full article at: http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html> > Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors> Abstract> Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified

DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a> genetically diverse group of MLV-related viruses. The gag and env sequences from CFS patients

were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply. > Source: www.pnas.org> > > News articles about the study: > http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c.html?xid=rss-topstories > http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1 > http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.html > http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue > WPI congratulates Alter and Lo:

> http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823 > > Kind regards > ESME> > > > The European

Society for ME is a non-profit group, operated entirely by volunteers. You can support ESME with a donation by visiting: http://esme-eu.com/donate/category114.html.> > Your donation will go directly to our goals of educating doctors and helping scientists to solve the puzzle of ME/CFS: www.esme-eu.com.> >

[Guest guest]

thanks!

From: Sue <suebackagain123@...>Subject: Re: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patientsinfections Date: Thursday, August 26, 2010, 6:47 AM

hi barb. please tell your friend that he can be tested for the antibodies to the MLV-related viruses and XMRV at VIP diagnostics. he has to call and order a testing kit. i think the test will cost about $250.

sue

From: egroups1bp <bpeck9191@...>infections Sent: Thu, August 26, 2010 8:35:04 AMSubject: [infections] Re: Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

I've forwarded all this info to my CFS friend- who is very disabled.I hope now he can find a Doc.. (and he has many) that can get him in a drug trial- or prescribe an anti-viral that may help him..This is BIG news.. especially since the initial news was sort of poo pooed.Barb> > > From: ESME European Society for ME <post@...>> Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients> "ESME European society of ME" <post@...>> Date: Tuesday, August 24, 2010, 12:48 AM> > > > > > >

> > > > > > > ESME IVWZ> KBO: 0817.905.582> > > The long-awaited FDA/NIH study was released yesterday. Four types of MLV-related viruses were found in CFS patients and one healthy blood donor. The team, lead by Harvey Alter of the National Institutes of Health, said their finding adds to evidence that viruses may be linked with the debilitating condition. (CFS)> Read the abstract below or the full article at: http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html> > Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors> Abstract> Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified

DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a> genetically diverse group of MLV-related viruses. The gag and env sequences from CFS patients

were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply. > Source: www.pnas.org> > > News articles about the study: > http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c.html?xid=rss-topstories > http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1 > http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.html > http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue > WPI congratulates Alter and Lo:

> http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823 > > Kind regards > ESME> > > > The European

Society for ME is a non-profit group, operated entirely by volunteers. You can support ESME with a donation by visiting: http://esme-eu.com/donate/category114.html.> > Your donation will go directly to our goals of educating doctors and helping scientists to solve the puzzle of ME/CFS: www.esme-eu.com.> >