Fw: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

[Guest guest]

From: ESME European Society for ME <post@...>Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients"ESME European society of ME" <post@...>Date: Tuesday, August 24, 2010, 12:48 AM

ESME IVWZ

KBO: 0817.905.582

The long-awaited FDA/NIH study was released yesterday. Four types of MLV-related viruses were found in CFS patients and one healthy blood donor. The team, lead by Harvey Alter of the National Institutes of Health, said their finding adds to evidence that viruses may be linked with the debilitating condition. (CFS)

Read the abstract below or the full article at: http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html

Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors

Abstract

Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause. A recent study identified DNA from a xenotropic murine leukemia virus-related virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101 patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls. However, four subsequent reports failed to detect any murine leukemia virus (MLV)-related virus gene sequences in blood of CFS patients. We examined 41 PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse DNA contamination was detected in the PCR assay system or the clinical samples. Seven of 8 gag-positive patients tested

again positive in a sample obtained nearly 15 y later. In contrast to the reported findings of near-genetic identity of all XMRVs, we identified a genetically diverse group of MLV-related viruses. The gag and env sequences from CFS patients were more closely related to those of polytropic mouse endogenous retroviruses than to those of XMRVs and were even less closely related to those of ecotropic MLVs. Further studies are needed to determine whether the same strong association with MLV-related viruses is found in other groups of patients with CFS, whether these viruses play a causative role in the development of CFS, and whether they represent a threat to the blood supply.

Source: www.pnas.org

News articles about the study:

http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c.html?xid=rss-topstories

http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1

http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.html

http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue

WPI congratulates Alter and Lo:

http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823

Kind regards

ESME

The European Society for ME is a non-profit group, operated entirely by volunteers. You can support ESME with a donation by visiting: http://esme-eu.com/donate/category114.html.

Your donation will go directly to our goals of educating doctors and helping scientists to solve the puzzle of ME/CFS: www.esme-eu.com.

[Guest guest]

I've forwarded all this info to my CFS friend- who is very disabled.

I hope now he can find a Doc.. (and he has many) that can get him in a drug

trial- or prescribe an anti-viral that may help him..

This is BIG news.. especially since the initial news was sort of poo pooed.

Barb

>

>

> From: ESME European Society for ME <post@...>

> Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

> " ESME European society of ME " <post@...>

> Date: Tuesday, August 24, 2010, 12:48 AM

>

>

>

>

>

>

>

>

>

>

>

>

>

> ESME IVWZ

> KBO: 0817.905.582

>  

>  

> The long-awaited FDA/NIH study was released yesterday. Four types of

MLV-related viruses were found in CFS patients and one healthy blood donor. The

team, lead by Harvey Alter of the National Institutes of Health, said their

finding adds to evidence that viruses may be linked with the debilitating

condition. (CFS)

> Read the abstract below or the full article at:

http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html

>  

> Detection of MLV-related virus gene sequences in blood of patients with

chronic fatigue syndrome and healthy blood donors

> Abstract

> Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown cause.

A recent study identified DNA from a xenotropic murine leukemia virus-related

virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101

patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy controls.

However, four subsequent reports failed to detect any murine leukemia virus

(MLV)-related virus gene sequences in blood of CFS patients. We examined 41

PBMC-derived DNA samples from 37 patients meeting accepted diagnostic criteria

for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%) compared

with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse

DNA contamination was detected in the PCR assay system or the clinical samples.

Seven of 8 gag-positive patients tested again positive in a sample obtained

nearly 15 y later. In contrast to the reported findings of near-genetic identity

of all XMRVs, we identified a

> genetically diverse group of MLV-related viruses. The gag and env sequences

from CFS patients were more closely related to those of polytropic mouse

endogenous retroviruses than to those of XMRVs and were even less closely

related to those of ecotropic MLVs. Further studies are needed to determine

whether the same strong association with MLV-related viruses is found in other

groups of patients with CFS, whether these viruses play a causative role in the

development of CFS, and whether they represent a threat to the blood supply.

> Source: www.pnas.org

>  

>  

> News articles about the study:

>

http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c.\

html?xid=rss-topstories

> http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1

>

http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.h\

tml

> http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue

> WPI congratulates Alter and Lo: 

> http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823

>  

> Kind regards

> ESME

>  

>  

>  

> The European Society for ME is a non-profit group, operated entirely by

volunteers. You can support ESME with a donation by visiting:

http://esme-eu.com/donate/category114.html.

>  

> Your donation will go directly to our goals of educating doctors and helping

scientists to solve the puzzle of ME/CFS: www.esme-eu.com.

>  

>

[Guest guest]

Thanks will do.

B

> >

> >

> > From: ESME European Society for ME <post@>

> > Subject: Study by FDA and NIH finds XMRV-like virus in 86.5% of CFS patients

> > " ESME European society of ME " <post@>

> > Date: Tuesday, August 24, 2010, 12:48 AM

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> >

> > ESME IVWZ

> > KBO: 0817.905.582

> >  

> >  

> > The long-awaited FDA/NIH study was released yesterday. Four types of

> >MLV-related viruses were found in CFS patients and one healthy blood donor.

The

> >team, lead by Harvey Alter of the National Institutes of Health, said their

> >finding adds to evidence that viruses may be linked with the debilitating

> >condition. (CFS)

> > Read the abstract below or the full article at:

> >http://www.pnas.org/content/early/2010/08/16/1006901107.full.pdf+html

> >  

> > Detection of MLV-related virus gene sequences in blood of patients with

chronic

> >fatigue syndrome and healthy blood donors

> > Abstract

> > Chronic fatigue syndrome (CFS) is a serious systemic illness of unknown

cause.

> >A recent study identified DNA from a xenotropic murine leukemia virus-related

> >virus (XMRV) in peripheral blood mononuclear cells (PBMCs) from 68 of 101

> >patients (67%) by nested PCR, as compared with 8 of 218 (3.7%) healthy

controls.

> >However, four subsequent reports failed to detect any murine leukemia virus

> >(MLV)-related virus gene sequences in blood of CFS patients. We examined 41

> >PBMC-derived DNA samples from 37 patients meeting accepted diagnostic

criteria

> >for CFS and found MLV-like virus gag gene sequences in 32 of 37 (86.5%)

compared

> >with only 3 of 44 (6.8%) healthy volunteer blood donors. No evidence of mouse

> >DNA contamination was detected in the PCR assay system or the clinical

samples.

> >Seven of 8 gag-positive patients tested again positive in a sample obtained

> >nearly 15 y later. In contrast to the reported findings of near-genetic

identity

> >of all XMRVs, we identified a

> > genetically diverse group of MLV-related viruses. The gag and env sequences

> >from CFS patients were more closely related to those of polytropic mouse

> >endogenous retroviruses than to those of XMRVs and were even less closely

> >related to those of ecotropic MLVs. Further studies are needed to determine

> >whether the same strong association with MLV-related viruses is found in

other

> >groups of patients with CFS, whether these viruses play a causative role in

the

> >development of CFS, and whether they represent a threat to the blood supply.

> >

> > Source: www.pnas.org

> >  

> >  

> > News articles about the study:

>

>http://voices.washingtonpost.com/checkup/2010/08/new_evidence_virus_may_cause_c\

..html?xid=rss-topstories

> >s

> >

> > http://www.nytimes.com/2010/08/24/health/research/24fatigue.html?_r=1

>

>http://news.sciencemag.org/sciencenow/2010/08/second-paper-supports-viral-link.\

html

> >l

> >

> > http://news./s/ap/20100823/ap_on_he_me/us_med_chronic_fatigue

> > WPI congratulates Alter and Lo: 

> > http://www.reuters.com/article/healthNews/idUSTRE67M55S20100823

> >  

> > Kind regards

> > ESME

> >  

> >  

> >  

> > The European Society for ME is a non-profit group, operated entirely by

> >volunteers. You can support ESME with a donation by visiting:

> >http://esme-eu.com/donate/category114.html.

> >  

> > Your donation will go directly to our goals of educating doctors and helping

> >scientists to solve the puzzle of ME/CFS: www.esme-eu.com.

> >  

> >

>