Re: Simplified Methylation Protocol Revised as of Today

March 30, 2011

Thanks Rich

Currently I am on the old protocol including injectable Hyddroxo B12

I have added to that a combined antibiotic protocol for a chronic

infection

Thanks for you contributions

Steve

On Mar 30, 2011, at 12:02 PM, rvankonynen wrote:

> Hi,all.

>

> As of today, I am suggesting a revised form of the Simplified

> Treatment Approach for lifting the partial methylation cycle block i

> ME/CFS. The revised form is shown below.

>

> The changes involve using liquid supplements where possible, and a

> capsule rather than a tablet, so that dosages can be divided more

> easily. Hopefully this will be more convenient than having to split

> tablets.

>

> I've eliminated folic acid from the protocol in favor of the active,

> reduced forms of folate, exclusively, since folic acid is not

> readily utilized by some patients, and it competes with the active

> forms for absorption.

>

> I've also provided for use of lecithin in place of

> phosphatidylserine complex, because the latter can decrease cortisol

> in patients whose

> cortisol is already too low.

>

> I would appreciate any feedback on how this works out for those of

> you who decide to try it.

>

> Best regards,

>

> Rich

>

> March 30. 2011

>

> SIMPLIFIED TREATMENT APPROACH

> FOR LIFTING THE METHYLATION CYCLE BLOCK

> IN CHRONIC FATIGUE SYNDROME—March 30, 2011 Revision

> Rich Van Konynenburg. Ph.D.

> (Based on the full treatment program

> developed by Amy Yasko, Ph.D., N.D.

> which is used primarily in treating autism [1])

>

> SUPPLEMENTS

>

> 1. General Vitamin Neurological Health Formula [2]: Start with ¼

> tablet and increase dosage as tolerated to 2 tablets daily

> 2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily

> 3. MethylMate B [4]: 3 drops under the tongue daily

> 4. Folinic acid [5]: ¼ capsule daily

> 5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or

> lecithin, see below)

>

> All these supplements can be obtained from http://

> www.holisticheal.com.

> The fourth supplement comes in capsules that contain 800 mcg. It

> will be necessary to open the capsules, dump the powder onto a flat

> surface, and separate it into quarters using a knife to obtain the

> daily dose. The powder can be taken orally with water, with or

> without food.

> These supplements can make some patients sleepy, so in those cases

> they take them at bedtime. In general, they can be taken at any time

> of day, with or without food.

> Phosphatidyl serine can lower cortisol levels. Patients who already

> have lower than normal cortisol may wish to substitute lecithin [7]

> (at one softgel daily) for supplement number 5 above. Lecithin is

> also available from http://www.holisticheal.com.

> GO SLOWLY. As the methylation cycle block is lifted, toxins are

> released and processed by the body, and this can lead to an

> exacerbation of symptoms. IF THIS HAPPENS, try smaller doses, every

> other day. SLOWLY work up to the full dosages.

> Although this treatment approach consists only of nonprescription

> nutritional supplements, a few patients have reported adverse

> effects while on it. Therefore, it is necessary that patients be

> supervised by physicians while receiving this treatment.

>

> [1] Yasko, Amy, Autism, Pathways to Recovery, Neurological Research

> Institute, 2009, available from http://www.holisticheal.com or Amazon.

> [2] General Vitamin Neurological Health Formula is formulated and

> supplied by Holistic Health Consultants LLC.

> [3] Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin

> (B12), supplied by Holistic Health Consultants. 2 drops is a dosage

> of 2,000 mcg.

> [4] MethylMate B is a liquid form of (6s)-methyltetrahydrofolate

> supplied by Holistic Health Consultants, based on Extrafolate S, a

> trademark of Gnosis S.P.A. 3 drops is a dosage of 210 mcg.

> [5] Folinic acid is 5-formyltetrahydrofolate. ¼ capsule is a dosage

> of 200 mcg.

> [5] Phosphatidyl Serine Complex is a product of Vitamin Discount

> Center. 1 softgel is a dosage of 500 mg.

> [7] Lecithin is a combination of phospholipids without

> phosphatidylserine. One softgel is a dosage of 1,200 mg.

>

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March 30, 2011

Hi Rich,

These are two very awesome changes. I never understood why the multi had folic

acid - the reasons you mention make sense. I have actually never had my son or

myself on the multi as I could never afford the shipping from Maine. I have us

both on Klaire Labs Vita Spectrum which has no iron, no copper, little B6 and

only folate (5 MTHF). I feel great on it (2 capsules - while my son is at 4

capsules)

I have come to a nice, stable place that I am reluctant to push the detox with

further phases of the protocol!

Thanks for keeping us updated.

Marti

P.S.

I will try to update the files on this forum as well as CFS_Yasko (if it hasn't

already been done).

>

> Hi,all.

>

> As of today, I am suggesting a revised form of the Simplified Treatment

Approach for lifting the partial methylation cycle block i ME/CFS. The revised

form is shown below.

>

> The changes involve using liquid supplements where possible, and a capsule

rather than a tablet, so that dosages can be divided more easily. Hopefully

this will be more convenient than having to split tablets.

>

> I've eliminated folic acid from the protocol in favor of the active, reduced

forms of folate, exclusively, since folic acid is not readily utilized by some

patients, and it competes with the active forms for absorption.

>

> I've also provided for use of lecithin in place of phosphatidylserine complex,

because the latter can decrease cortisol in patients whose

> cortisol is already too low.

>

> I would appreciate any feedback on how this works out for those of you who

decide to try it.

>

> Best regards,

>

> Rich

>

> March 30. 2011

>

> SIMPLIFIED TREATMENT APPROACH

> FOR LIFTING THE METHYLATION CYCLE BLOCK

> IN CHRONIC FATIGUE SYNDROME—March 30, 2011 Revision

> Rich Van Konynenburg. Ph.D.

> (Based on the full treatment program

> developed by Amy Yasko, Ph.D., N.D.

> which is used primarily in treating autism [1])

>

> SUPPLEMENTS

>

> 1. General Vitamin Neurological Health Formula [2]: Start with ¼ tablet and

increase dosage as tolerated to 2 tablets daily

> 2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily

> 3. MethylMate B [4]: 3 drops under the tongue daily

> 4. Folinic acid [5]: ¼ capsule daily

> 5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or lecithin,

see below)

>

> All these supplements can be obtained from http://www.holisticheal.com.

> The fourth supplement comes in capsules that contain 800 mcg. It will be

necessary to open the capsules, dump the powder onto a flat surface, and

separate it into quarters using a knife to obtain the daily dose. The powder can

be taken orally with water, with or without food.

> These supplements can make some patients sleepy, so in those cases they

take them at bedtime. In general, they can be taken at any time of day, with or

without food.

> Phosphatidyl serine can lower cortisol levels. Patients who already have

lower than normal cortisol may wish to substitute lecithin [7] (at one softgel

daily) for supplement number 5 above. Lecithin is also available from

http://www.holisticheal.com.

> GO SLOWLY. As the methylation cycle block is lifted, toxins are released

and processed by the body, and this can lead to an exacerbation of symptoms. IF

THIS HAPPENS, try smaller doses, every other day. SLOWLY work up to the full

dosages.

> Although this treatment approach consists only of nonprescription

nutritional supplements, a few patients have reported adverse effects while on

it. Therefore, it is necessary that patients be supervised by physicians while

receiving this treatment.

>

> [1] Yasko, Amy, Autism, Pathways to Recovery, Neurological Research

Institute, 2009, available from http://www.holisticheal.com or Amazon.

> [2] General Vitamin Neurological Health Formula is formulated and supplied by

Holistic Health Consultants LLC.

> [3] Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin (B12),

supplied by Holistic Health Consultants. 2 drops is a dosage of 2,000 mcg.

> [4] MethylMate B is a liquid form of (6s)-methyltetrahydrofolate supplied by

Holistic Health Consultants, based on Extrafolate S, a trademark of Gnosis

S.P.A. 3 drops is a dosage of 210 mcg.

> [5] Folinic acid is 5-formyltetrahydrofolate. ¼ capsule is a dosage of 200

mcg.

> [5] Phosphatidyl Serine Complex is a product of Vitamin Discount Center. 1

softgel is a dosage of 500 mg.

> [7] Lecithin is a combination of phospholipids without phosphatidylserine.

One softgel is a dosage of 1,200 mg.

>

March 30, 2011

Hi Rich,

I hope to finally try methylation at some point, after years of

watching you post it and finding it difficult to organize but wanting

to try it.

One question:

On 2011-03-30, rvankonynen <richvank@...> wrote:

> The changes involve using liquid supplements where possible, and a capsule

> rather than a tablet, so that dosages can be divided more easily. Hopefully

> this will be more convenient than having to split tablets.

Do both tablets and capsules distribute the active ingredient with

sufficient uniformity for this? I presume the answer is yes.

> Although this treatment approach consists only of nonprescription

> nutritional supplements, a few patients have reported adverse effects while

> on it. Therefore, it is necessary that patients be supervised by physicians

> while receiving this treatment.

As many don't have physicians (including many bedridden and

housebound) or cannot access them frequently, and many who do do not

have well-informed or M.E.-aware physicians, a sense of the severity

and permanence of those adverse effects would be great to obtain. Is

there a good concise updated source?

Thanks as always for studying neuroimmune diseases and sticking with

it. BTW, what's your connection to the disease, if I may ask? I

don't recall your bio ATM and a quick search didn't find it.

--

The Kafka Pandemic:

http://thekafkapandemic.blogspot.com/2010/12/welcome-to-kafka-pandemic-two-force\

s_9182.html

I support the Whittemore- Institute (WPI)

===

I want to see the original (pre-hold) Lo et al. 2010 NIH/FDA/Harvard MRV paper.

March 30, 2011

Hi, .

You are certainly welcome for whatever I have been able to do that is helpful.

I think that both the tablets and the capsules are fine, but the tablets have

been difficult for people to split, and I think the capsules will be easier to

deal with. I wasn't able to find a liquid form of folinic acid, so that's why

the folinic acid capsules are part of this revised protocol.

I began working on ME/CFS 15 years ago, when a family friend developed CFS. I

learned on the internet, especially in this group, how many people have this

disorder, and I became motivated to try to help, as well as becoming " hooked " on

the scientific problem involved in trying to understand this disorder.

Here is a summary of the serious adverse effects that have been reported to me:

1. One person had had a history of severe pesticide exposure and also

autonomous multi-nodular goiter, which she described as follows: " Gradually the

right lobe grew to over 4 cm x 4cm, and had to have right lobe out. . . This

same surgeon made the decision to leave the left lobe in, as I had always had

trouble with thyroid med back then too. So, they restarted my Synthroid and I

stayed on that for [a] few more years. I ALWAYS had shortness of breath and

became VERY tachycardic upon ANY activity. . . " This person started the

simplified treatment approach on March 21, 2007 (actually using higher dosages

than suggested for FolaPro and Intrinsi/B12/folate). On May 19, she went to an

emergency room with tachycardia, chest pain, trouble breathing, trouble

sleeping, elevated blood pressure and fever of 100.7 F. She was admitted to the

hospital and released the next day. No evidence was found for heart attack.

This person later reported the following: " I followed up with my PCP and had CT

scan of neck and chest and my goiter is causing tracheal compression, again, and

breathing is VERY hard. . . My area hospitals can't do this surgery because my

goiter grows substernal, deep in my chest. " This person has expressed a desire

to continue the simplified treatment approach, but is currently exploring the

possibility of first having additional surgery on the multinodular goiter.

2. A second person had a history of lung problems due to both carbon monoxide

exposure and exposure to molds, as well as heart-related symptoms. She started

part of the simplified treatment approach on May 27, 2007. After having been

nearly homebound for ten years, she was able to begin riding a bicycle.

However, in early July, 2007, she went to an emergency room twice with severe

breathing problems (shortness of breath), a fever of 99.8 to 100.1 F. that

eventually lasted for sixteen days, and severe chest and left arm pain. No

evidence was found for heart attack. She was diagnosed with an enlarged left

atrium and diastolic dysfunction. She has currently discontinued the simplified

treatment approach and is under the care of cardiologists.

3. A third person had a history of autoimmune disease, including Sjogren's

syndrome. After her fourth dosage of combined FolaPro and Intrinsi/B12/folate,

she experienced " a moderately severe autoimmune flare, with numerous joint and

soft tissue issues, fatigue, pain, etc. " She also experienced a severe flare of

Sjogren's syndrome, with " very dry mouth, dry eyes, and severe eye pain. " Six

days after discontinuing the supplements, she had a thorough ophthalmology

workup and was diagnosed with autoimmune scleritis. She has been given topical

steroids and has reported that her eyes are greatly improved.

4. At least two persons experienced a temporary termination of peristalsis of

the gut and consequent constipation after beginning the simplified treatment

approach. In these two cases, induction of diarrhea cleared material from the

gut, but did not restore the peristalsis. In both cases, peristalsis restarted

twelve days after terminating the folate-containing supplements. One of these

persons had a history of treatment with psychotropic drugs, including Klonopin.

About 18 hours after starting to get relief from the constipation, she became

very sick, with " vomiting, vise-like headache, and shaking. " She had many bowel

movements over a ten-hour period, and then began to feel better. The other had

a history of autoimmune diseases, including Sjogren's syndrome and Autoimmune

Ovaritis, as well as diastolic dysfunction.

Best regards,

Rich

> > The changes involve using liquid supplements where possible, and a capsule

> > rather than a tablet, so that dosages can be divided more easily. Hopefully

> > this will be more convenient than having to split tablets.

>

> Do both tablets and capsules distribute the active ingredient with

> sufficient uniformity for this? I presume the answer is yes.

>

> > Although this treatment approach consists only of nonprescription

> > nutritional supplements, a few patients have reported adverse effects while

> > on it. Therefore, it is necessary that patients be supervised by physicians

> > while receiving this treatment.

>

> As many don't have physicians (including many bedridden and

> housebound) or cannot access them frequently, and many who do do not

> have well-informed or M.E.-aware physicians, a sense of the severity

> and permanence of those adverse effects would be great to obtain. Is

> there a good concise updated source?

>

> Thanks as always for studying neuroimmune diseases and sticking with

> it. BTW, what's your connection to the disease, if I may ask? I

> don't recall your bio ATM and a quick search didn't find it.

>

> --

> The Kafka Pandemic:

>

http://thekafkapandemic.blogspot.com/2010/12/welcome-to-kafka-pandemic-two-force\

s_9182.html

> I support the Whittemore- Institute (WPI)

> ===

> I want to see the original (pre-hold) Lo et al. 2010 NIH/FDA/Harvard MRV

paper.

>

March 31, 2011

Hi Rich

just thought I would let you know that my toxicity levels have reduced

significantly. I am the one that had the stool donor treatment here in Australia

and also found significant improvement by going on a low oxalate diet with

magnesium citrate and calcium citrate at meals to bind the oxalates in my diet.

Well I have just seen my hormone specialist who has also been monitoring my

liver toxicity levels. These treatments/approaches together with the methylation

supplements have returned my toxic liver results to normal and my hormone stress

levels are going back to normal. Also looking like I can get of thyroid hormones

as well. I will do another methylation panel soon, but last night given the

results I have just received I decided to have a glass of wine - something I

haven't done for near on 20 years because I just couldn't tolerate any alcohol -

no ill effects at all - lovely drop too. another quality of life treat I

can now add back to my life.

My energy is normal, I haven't stopped going, no relapses, late nights, early

mornings (every morning I now get up at 6am) interstate trips, rushing to and

from my new part time job, brisk walking every day for at least 40 minutes and

about to take on a personal trainer to get me strong again.

I urge you to look at the Austism Research Institutes' Austism Oxalate Project

headed by Owen. Also this site http://www.lowoxalate.info/ that

Owen set up.

Dietary oxalates could be contributing a significant amount of toxins to those

that have an altered gut permeability ie. anyone with cfs, fibromyalgia and

autism. Learning about oxalates certainly has turned my life around and I

sincerely wish that everyone with these chronic debilitating illness can achieve

the success I have had.

>

> Hi,all.

>

> As of today, I am suggesting a revised form of the Simplified Treatment

Approach for lifting the partial methylation cycle block i ME/CFS. The revised

form is shown below.

>

> The changes involve using liquid supplements where possible, and a capsule

rather than a tablet, so that dosages can be divided more easily. Hopefully

this will be more convenient than having to split tablets.

>

> I've eliminated folic acid from the protocol in favor of the active, reduced

forms of folate, exclusively, since folic acid is not readily utilized by some

patients, and it competes with the active forms for absorption.

>

> I've also provided for use of lecithin in place of phosphatidylserine complex,

because the latter can decrease cortisol in patients whose

> cortisol is already too low.

>

> I would appreciate any feedback on how this works out for those of you who

decide to try it.

>

> Best regards,

>

> Rich

>

> March 30. 2011

>

> SIMPLIFIED TREATMENT APPROACH

> FOR LIFTING THE METHYLATION CYCLE BLOCK

> IN CHRONIC FATIGUE SYNDROME—March 30, 2011 Revision

> Rich Van Konynenburg. Ph.D.

> (Based on the full treatment program

> developed by Amy Yasko, Ph.D., N.D.

> which is used primarily in treating autism [1])

>

> SUPPLEMENTS

>

> 1. General Vitamin Neurological Health Formula [2]: Start with ¼ tablet and

increase dosage as tolerated to 2 tablets daily

> 2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily

> 3. MethylMate B [4]: 3 drops under the tongue daily

> 4. Folinic acid [5]: ¼ capsule daily

> 5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or lecithin,

see below)

>

> All these supplements can be obtained from http://www.holisticheal.com.

> The fourth supplement comes in capsules that contain 800 mcg. It will be

necessary to open the capsules, dump the powder onto a flat surface, and

separate it into quarters using a knife to obtain the daily dose. The powder can

be taken orally with water, with or without food.

> These supplements can make some patients sleepy, so in those cases they

take them at bedtime. In general, they can be taken at any time of day, with or

without food.

> Phosphatidyl serine can lower cortisol levels. Patients who already have

lower than normal cortisol may wish to substitute lecithin [7] (at one softgel

daily) for supplement number 5 above. Lecithin is also available from

http://www.holisticheal.com.

> GO SLOWLY. As the methylation cycle block is lifted, toxins are released

and processed by the body, and this can lead to an exacerbation of symptoms. IF

THIS HAPPENS, try smaller doses, every other day. SLOWLY work up to the full

dosages.

> Although this treatment approach consists only of nonprescription

nutritional supplements, a few patients have reported adverse effects while on

it. Therefore, it is necessary that patients be supervised by physicians while

receiving this treatment.

>

> [1] Yasko, Amy, Autism, Pathways to Recovery, Neurological Research

Institute, 2009, available from http://www.holisticheal.com or Amazon.

> [2] General Vitamin Neurological Health Formula is formulated and supplied by

Holistic Health Consultants LLC.

> [3] Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin (B12),

supplied by Holistic Health Consultants. 2 drops is a dosage of 2,000 mcg.

> [4] MethylMate B is a liquid form of (6s)-methyltetrahydrofolate supplied by

Holistic Health Consultants, based on Extrafolate S, a trademark of Gnosis

S.P.A. 3 drops is a dosage of 210 mcg.

> [5] Folinic acid is 5-formyltetrahydrofolate. ¼ capsule is a dosage of 200

mcg.

> [5] Phosphatidyl Serine Complex is a product of Vitamin Discount Center. 1

softgel is a dosage of 500 mg.

> [7] Lecithin is a combination of phospholipids without phosphatidylserine.

One softgel is a dosage of 1,200 mg.

>

March 31, 2011

That is exciting news. Sounds like you are really in the pink. I too

started the LOD diet and joined Owens group. I have been on it

about 2 mos and on the cal & mag citrate for 2 weeks. My energy level has been

going up, and a life long battle with constipation is over since going LOD and

adding just these 2 supplements. Also a life long severe allergy to

animals(talkin 45 yrs worth) is gone after 5 mos on LDN. I have been following

Rich and his work on several forums with the hope that someday I will be able

to afford the Methylation Panel test......... if they keep uncovering more stuff

about CFS, and it becomes more of a " mainstream " illness, and they see how much

some folks are clearly helped by Rich's protocol,maybe my medicare will cover

it! In the meantime I do what I can with very little money........LOD & LDN has

been life saver for me and the best part, I dont need a Dr, a scrip, and both

are inexpensive to follow!Rich is gaurdian angel for us PWCFS.............he

keeps an eye on us. Much Gratitude Rich, we need you. dolores

Re: Simplified Methylation Protocol Revised as of

Today