Simplified Methylation Protocol Revised as of Today

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Hi,all.

As of today, I am suggesting a revised form of the Simplified Treatment Approach

for lifting the partial methylation cycle block in ME/CFS. The revised form is

shown below.

The changes involve using liquid supplements where possible, and a capsule

rather than a tablet, so that dosages can be divided more easily. Hopefully

this will be more convenient than having to split tablets.

I've eliminated folic acid from the protocol in favor of the active, reduced

forms of folate, except for what is included in the multi, since folic acid is

not readily utilized by some

patients, and it competes with the active forms for absorption.

I've also provided for use of lecithin in place of phosphatidylserine complex,

because the latter can decrease cortisol in patients whose

cortisol is already too low.

Because the nutrient content of this revised protocol is essentially the same as

in the earlier version, the results of the clinical study performed by Neil

, M.D. and myself should also apply to theisrevised protocol.

I would appreciate any feedback on how this works out for those of you who

decide to try it.

Best regards,

Rich Van Konynenburg

March 30. 2011

SIMPLIFIED TREATMENT APPROACH

FOR LIFTING THE METHYLATION CYCLE BLOCK

IN CHRONIC FATIGUE SYNDROME—March 30, 2011 Revision

Rich Van Konynenburg. Ph.D.

(Based on the full treatment program

developed by Amy Yasko, Ph.D., N.D.

which is used primarily in treating autism [1])

SUPPLEMENTS

1. General Vitamin Neurological Health Formula [2]: Start with ¼ tablet and

increase dosage as tolerated to 2 tablets daily

2. Hydroxy B12 Mega Drops [3]: 2 drops under the tongue daily

3. MethylMate B [4]: 3 drops under the tongue daily

4. Folinic acid [5]: ¼ capsule daily

5. Phosphatidyl Serine Complex [6]: 1 softgel capsule daily (or lecithin, see

below)

All these supplements can be obtained from http://www.holisticheal.com.

The fourth supplement comes in capsules that contain 800 mcg. It will be

necessary to open the capsules, dump the powder onto a flat surface, and

separate it into quarters using a knife to obtain the daily dose. The powder can

be taken orally with water, with or without food.

These supplements can make some patients sleepy, so in those cases they

take them at bedtime. In general, they can be taken at any time of day, with or

without food.

Phosphatidyl serine can lower cortisol levels. Patients who already have lower

than normal cortisol may wish to substitute lecithin [7] (at one softgel daily)

for supplement number 5 above. Lecithin is also available from

http://www.holisticheal.com.

GO SLOWLY. As the methylation cycle block is lifted, toxins are released

and processed by the body, and this can lead to an exacerbation of symptoms. IF

THIS HAPPENS, try smaller doses, every other day. SLOWLY work up to the full

dosages.

Although this treatment approach consists only of nonprescription

nutritional supplements, a few patients have reported adverse effects while on

it. Therefore, it is necessary that patients be supervised by physicians while

receiving this treatment.

[1] Yasko, Amy, Autism, Pathways to Recovery, Neurological Research Institute,

2009, available from http://www.holisticheal.com or Amazon.

[2] General Vitamin Neurological Health Formula is formulated and supplied by

Holistic Health Consultants LLC.

[3] Hydroxy B12 Mega Drops is a liquid form of hydroxocobalamin (B12), supplied

by Holistic Health Consultants. 2 drops is a dosage of 2,000 mcg.

[4] MethylMate B is a liquid form of (6s)-methyltetrahydrofolate supplied by

Holistic Health Consultants, based on Extrafolate S, a trademark of Gnosis

S.P.A. 3 drops is a dosage of 210 mcg.

[5] Folinic acid is 5-formyltetrahydrofolate. ¼ capsule is a dosage of 200 mcg.

[5] Phosphatidyl Serine Complex is a product of Vitamin Discount Center. 1

softgel is a dosage of 500 mg.

[7] Lecithin is a combination of phospholipids without phosphatidylserine. One

softgel is a dosage of 1,200 mg.