CDK5 Signaling Pathway was found to be highly upregulated in CFS

[Guest guest]

Just got my NCF publication 'The National Forum' -Spring 2011 issue.

In it, an informative article, about that CFS -Lyme Spinal fluid study that was

in the news a few weeks ago*

It mentions:

The CDK5 signaling pathway was found to be highly upregulated in CFS ,

CDK5 is implicated in Alzheimer's and Parkinson's Diseases.

CDK5 is a crucial regulator of neuronal migration in the developing

central nervous system.

research indicates it dysregualtion is involved in the pathology of

neurodegenerative diseases.

Also, in learning and memory, neurological pathology, and plays role in

pain signaling and opioid tolerance.

Reference:

* Distinct cerebrospinal fluid proteomes differentiate post treatment

Lyme disease

from Chronic Fatigue Syndrome; Shuster SE, Angel TE, Liu T., Schepmoes AA,

Clause TR, et al. PLos ONE 6(2): el7287, 2011