Guest guest Posted May 4, 2002 Report Share Posted May 4, 2002 Where do you buy this product and what did the doctor say it would help with? Sounds interesting. >From: " cyndibear3 " <cyndibear3@...> >Reply- > >Subject: [ ] L-Carnosine >Date: Sat, 04 May 2002 15:53:21 -0000 > >We just started my 4.10 y.o. son on Carn-aware (L-Carnosine)at the >recommendation of his doctor and have seen some great things in a >short period of time, (improved eye contact, better pronounciation >of words). Does anyone else have their child on this product or >know anything about this supplement? >Cyndi > _________________________________________________________________ Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 4, 2002 Report Share Posted May 4, 2002 My 4.11 yo dtr. is using carnosine. After the first few doses, we got a BURST of new expressive language. However, after the first few days, things have levelled off. I will continue using it, and just observe the next few weeks to decide if it's a " keeper. " > We just started my 4.10 y.o. son on Carn-aware (L-Carnosine)at the > recommendation of his doctor and have seen some great things in a > short period of time, (improved eye contact, better pronounciation > of words). Does anyone else have their child on this product or > know anything about this supplement? > Cyndi Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 4, 2002 Report Share Posted May 4, 2002 Dr. Chez in Chicago is doing a study on it and I heard that some kids are doing very well on it. I also heard that it makes some kids hyper. ________________________________________________________________ GET INTERNET ACCESS FROM JUNO! Juno offers FREE or PREMIUM Internet access for less! Join Juno today! For your FREE software, visit: http://dl.www.juno.com/get/web/. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2002 Report Share Posted October 15, 2002 In a message dated 10/15/02 6:14:00 PM Pacific Daylight Time, madelinemelissa@... writes: << com I have had my son on Carnosine for 3 weeks or a little more and both his teacher and aide have commented that he is becoming more verbal with them. I haven't mentioned any changes to them. Maddie >> **********what dose are you using, and how old is your child? angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2002 Report Share Posted October 15, 2002 I have had my son on Carnosine for 3 weeks or a little more and both his teacher and aide have commented that he is becoming more verbal with them. I haven't mentioned any changes to them. Maddie > Double-Blind, Placebo-controlled Study of L-carnosine supplementation in children with autistic spectrum disorder > > > G. CHez, M.D., Cathleen P. Buchanan, Ph.D., > > L. Komen, M.A., Marina Becker, R.N. > > Objective: L-Carnosine is an amino acid dipeptide that may enhance frontal lobe function. We therefore sought to investigate whether L- Carnosine supplementation for children with Autistic Spectrum Disorders (ASD) results in observable, objective changes in language and/or behavior in contrast to placebo. > > Design/Methods: Thirty-one children (21 M, mean age= 7.45; range = 3.2-12.5 yrs )meeting inclusion criteria were enrolled in an 8 week blinded trial of either 400 mg BID powdered L-Carnosine or placebo. Children were assessed at a pediatric neurology clinic with the Childhood Autism Rating Scale (CARS), the Gilliam Autism Rating Scale (GARS), the Expressive and Receptive One-Word Picture Vocabulary tests (E/ROWPVT), and biweekly parental Clinical Global Impression of Change (CGI), at baseline and 8 week endpoint. > > > Results: Children who were on placebo (n=17) did not show statistically significant changes on any of the outcome measures. After 8 weeks on L-Carnosine, children (n=14) showed statistically significant improvements on the GARS total score, GARS Behavior, Socialization, and Communication subscales, and the ROWPVT (all p's<.05). EOWPVT and CARS showed trends in improvements, which were supported by parental CGI. > > > Conclusions: Oral supplementation with L-Carnosine resulted in demonstrable improvements in autistic behaviors as well as increases in language comprehension that reached statistical significance. Although the mechanism of action of the amino acid is not well understood, it is believed that it acts to modulate neurotransmission and affect metal ion transfer of zinc and copper in the entorhinal cortex. This may enhance neurological function or act in a neuroprotective fashion. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2002 Report Share Posted October 15, 2002 <<Thirty-one children (21 M, mean age= 7.45; range = 3.2-12.5 yrs )meeting inclusion criteria were enrolled in an 8 week blinded trial of either 400 mg BID powdered L-Carnosine or placebo. >> Does this mean that 31 children total were studied? Or were 31 children given placebo and 31 given the real thing? Thanks, Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 15, 2002 Report Share Posted October 15, 2002 Interesting information regarding L-carnosine and zinc....the combination is being used as a treatment for peptic ulcers in Japan. The lonza group claims to hold a patent on zinc/carnosine, but for what application, I have no idea. Just thought this interesting in light of all the buzz on carnosine/carn-aware. www.lonzagroup.com > > Lonza Inc., announced that the US Food and Drug Administration has allowed the sale of Zinc-Carnosine, the subject of a new dietary ingredient submission to the federal agency. Zinc-Carnosine is a patented zinc-carnosine complex supported by abundant human and animal data. > > > > > > > > Lonza has an exclusive distribution agreement to market the ingredient in North America and Europe. Zinc-Carnosine or Polaprezinc (INN) has been used in Japan for over a decade as an ulcer-healing drug. Hamari Chemicals manufactures and holds the patents on this unique compound. Zinc-Carnosine offers exceptional, “drug-like†patent protection, in that the molecule itself is claimed. This provides Lonza’s strategic marketing partners exceptional exclusivity. Zinc-Carnosine is a coordination complex of zinc with the dipeptide L-carnosine. “Zinc-Carnosine is a unique molecular entity, with biological activity different than that of zinc mixed with carnosine,†offered L. Almada, MSc, President and Chief Scientific Officer of IMAGINutrition. He added, “We believe Zinc Carnosine’s data and intellectual property package will usher in a new category of evidence-based dietary supplementsâ€. Lonza Group is a Life Sciences driven chemical company headquartered in Switzerland, with sales of CHF 2.5 billion in 2001 and operating 21 production and R & D facilities in 9 countries. It employs 6 400 people worldwide and is the leading supplier of active chemical ingredients, intermediates and biotechnology solutions to the pharmaceutical and agrochemical industries. It also offers a broad catalogue of organic intermediates for a wide range of applications such as pharmaceuticals, agrochemicals, vitamins, food and feedstuff, dyes and pigments, adhesives and fragrances. Furthermore the Group manufactures specialty biocides and oleochemicals and develops and produces specific polymer intermediates, unsaturated polyester-resins, compounds and composites. For more information on Lonza Group please visit the company’s website at www.lonzagroup.com. For further information please contact: Murray Lonza Inc. Tel +1 678 445 3535 Fax +1 678 445 3611 <A HREF= " mailto:dmurray2@... " >dmurray2@...</A> Liane Gentry Skye <A HREF= " http://talkingwithpictures.com/ " >Talking With Pictures</A> " nonverbal " does not have to mean " unable to communicate " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 16, 2002 Report Share Posted October 16, 2002 maddie, thanks for the information. How old is your child? angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 16, 2002 Report Share Posted October 16, 2002 My handwritten notes from DAN! Boston Pangborn's talk say that carnosine pulls copper into the body. Does anyone have more info on this? Please don't not try it because of my incomplete handwritten notes, but I would love to know more clearly what carnosine does in the body. Diane in NC >From: " Prokofiew " <aprokofiew@...> >Reply- >< > >Subject: [ ] L-carnosine >Date: Tue, 15 Oct 2002 18:28:37 -0700 > >Double-Blind, Placebo-controlled Study of L-carnosine supplementation in >children with autistic spectrum disorder > > > G. CHez, M.D., Cathleen P. Buchanan, Ph.D., > > L. Komen, M.A., Marina Becker, R.N. > >Objective: L-Carnosine is an amino acid dipeptide that may enhance frontal >lobe function. We therefore sought to investigate whether L-Carnosine >supplementation for children with Autistic Spectrum Disorders (ASD) results >in observable, objective changes in language and/or behavior in contrast to >placebo. > >Design/Methods: Thirty-one children (21 M, mean age= 7.45; range = 3.2-12.5 >yrs )meeting inclusion criteria were enrolled in an 8 week blinded trial of >either 400 mg BID powdered L-Carnosine or placebo. Children were assessed >at a pediatric neurology clinic with the Childhood Autism Rating Scale >(CARS), the Gilliam Autism Rating Scale (GARS), the Expressive and >Receptive One-Word Picture Vocabulary tests (E/ROWPVT), and biweekly >parental Clinical Global Impression of Change (CGI), at baseline and 8 week >endpoint. > > >Results: Children who were on placebo (n=17) did not show statistically >significant changes on any of the outcome measures. After 8 weeks on >L-Carnosine, children (n=14) showed statistically significant improvements >on the GARS total score, GARS Behavior, Socialization, and Communication >subscales, and the ROWPVT (all p's<.05). EOWPVT and CARS showed trends in >improvements, which were supported by parental CGI. > > >Conclusions: Oral supplementation with L-Carnosine resulted in demonstrable >improvements in autistic behaviors as well as increases in language >comprehension that reached statistical significance. Although the mechanism >of action of the amino acid is not well understood, it is believed that it >acts to modulate neurotransmission and affect metal ion transfer of zinc >and copper in the entorhinal cortex. This may enhance neurological function >or act in a neuroprotective fashion. > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 16, 2002 Report Share Posted October 16, 2002 , I actually have my son on L-Histidine which the body uses to make L- Carnosine. It is cheaper and less potent. I heard that L-Carnosine could cause hyperactivity so I started with the lesser of the two although I have a bottle of L-Carnosine that I plan to use when my Histidine runs out. Dosing - I give 500 mg L-Histidine twice a day on an empty (or the best we can do) tummy. Because Carn-aware has Selenium and Vitamin E (am I remembering this right?) I also give him these. I can't be sure it is helping him, I have also recently started giving him Milk Thistle 3x day instead of 1x, but I must say we have had a very smooth time in the last 10 days or so. Maddie > In a message dated 10/15/02 6:14:00 PM Pacific Daylight Time, > madelinemelissa@y... writes: > > << com > > I have had my son on Carnosine for 3 weeks or a little more and both > his teacher and aide have commented that he is becoming more verbal > with them. I haven't mentioned any changes to them. Maddie >> > **********what dose are you using, and how old is your child? > angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 16, 2002 Report Share Posted October 16, 2002 Diane, does this mean if you already have to much copper or copper is very high then L carnosine would be a bad idea.? Anyone I would love the answer. Kathy Diane Ritchie wrote: > My handwritten notes from DAN! Boston Pangborn's talk say that > carnosine pulls copper into the body. Does anyone have more info on this? > Please don't not try it because of my incomplete handwritten notes, but I > would love to know more clearly what carnosine does in the body. > Diane in NC > > >From: " Prokofiew " <aprokofiew@...> > >Reply- > >< > > >Subject: [ ] L-carnosine > >Date: Tue, 15 Oct 2002 18:28:37 -0700 > > > >Double-Blind, Placebo-controlled Study of L-carnosine supplementation in > >children with autistic spectrum disorder > > > > > > G. CHez, M.D., Cathleen P. Buchanan, Ph.D., > > > > L. Komen, M.A., Marina Becker, R.N. > > > >Objective: L-Carnosine is an amino acid dipeptide that may enhance frontal > >lobe function. We therefore sought to investigate whether L-Carnosine > >supplementation for children with Autistic Spectrum Disorders (ASD) results > >in observable, objective changes in language and/or behavior in contrast to > >placebo. > > > >Design/Methods: Thirty-one children (21 M, mean age= 7.45; range = 3.2-12.5 > >yrs )meeting inclusion criteria were enrolled in an 8 week blinded trial of > >either 400 mg BID powdered L-Carnosine or placebo. Children were assessed > >at a pediatric neurology clinic with the Childhood Autism Rating Scale > >(CARS), the Gilliam Autism Rating Scale (GARS), the Expressive and > >Receptive One-Word Picture Vocabulary tests (E/ROWPVT), and biweekly > >parental Clinical Global Impression of Change (CGI), at baseline and 8 week > >endpoint. > > > > > >Results: Children who were on placebo (n=17) did not show statistically > >significant changes on any of the outcome measures. After 8 weeks on > >L-Carnosine, children (n=14) showed statistically significant improvements > >on the GARS total score, GARS Behavior, Socialization, and Communication > >subscales, and the ROWPVT (all p's<.05). EOWPVT and CARS showed trends in > >improvements, which were supported by parental CGI. > > > > > >Conclusions: Oral supplementation with L-Carnosine resulted in demonstrable > >improvements in autistic behaviors as well as increases in language > >comprehension that reached statistical significance. Although the mechanism > >of action of the amino acid is not well understood, it is believed that it > >acts to modulate neurotransmission and affect metal ion transfer of zinc > >and copper in the entorhinal cortex. This may enhance neurological function > >or act in a neuroprotective fashion. > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 16, 2002 Report Share Posted October 16, 2002 , Sorry should have added: My son is 6.5 yo and weighs approx. 55lbs. > maddie, > thanks for the information. How old is your child? > angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 Dr. Chez said in his study that he used 400mg two times a day in his sample. Are you finding that is too much? i just ordered the Carn-Aware and am anxious to try it but do not know what dosage. My daughter weighs 32 pounds. Thanks- Keri Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 Actually, carnosine is made up of histidine and alanine. Some prefer histidine over carnosine because they believe it is the beneficial half and because they also believe it is the alanine that causes some kids to be hyper on carnosine. We started on carnosine, and he did get a little jumpy, and slightly more talkative. When we switched to histidine, he didn't back pedal on talkative, but he did dial it down a notch or two on his jumpiness. Also, I have heard that carnosine pulls copper out of the body, not into the body. This is more of an issue for Andy to chime in on... Max in VA > > In a message dated 10/15/02 6:14:00 PM Pacific Daylight Time, > > madelinemelissa@y... writes: > > > > << com > > > > I have had my son on Carnosine for 3 weeks or a little more and > both > > his teacher and aide have commented that he is becoming more > verbal > > with them. I haven't mentioned any changes to them. Maddie >> > > **********what dose are you using, and how old is your child? > > angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 Do you give the same doseage of histidine as carnosine? My 6 yr old son is up to 125 mg 2x/day of carnosine. I truely love this stuff but he is a little more " energetic. " I might want to try switching to the histidine once we've used the carnosine up. > > Actually, carnosine is made up of histidine and alanine. Some prefer > histidine over carnosine because they believe it is the beneficial > half and because they also believe it is the alanine that causes some > kids to be hyper on carnosine. We started on carnosine, and he > did get a little jumpy, and slightly more talkative. When we > switched to histidine, he didn't back pedal on talkative, but he did > dial it down a notch or two on his jumpiness. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 Yes, we went from 500mg of carnosine per day, divided into three doses, to 500mg of histidine per day, again divided into three doses. We order the histidine from www.cfsn.com, by the way. Max in VA > > > > Actually, carnosine is made up of histidine and alanine. Some > prefer > > histidine over carnosine because they believe it is the beneficial > > half and because they also believe it is the alanine that causes > some > > kids to be hyper on carnosine. We started on carnosine, and > he > > did get a little jumpy, and slightly more talkative. When we > > switched to histidine, he didn't back pedal on talkative, but he > did > > dial it down a notch or two on his jumpiness. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 In a message dated 10/17/02 7:09:01 AM Pacific Daylight Time, msalinas@... writes: << > I actually have my son on L-Histidine which the body uses to make L- > Carnosine. It is cheaper and less potent. I heard that L- Carnosine > could cause hyperactivity so I started with the lesser of the two > although I have a bottle of L-Carnosine that I plan to use when my > Histidine runs out. > Dosing - I give 500 mg L-Histidine twice a day on an empty (or the > best we can do) tummy. Because Carn-aware has Selenium and Vitamin > E (am I remembering this right?) I also give him these. I can't be > sure it is helping him, I have also recently started giving him Milk >> hi thanks for your response. Are you giving anyother supplements like folic acid and b-12? I did just buy the Carnosine, it is expensive, almost 50. 00 at the health food store. My son is on the hyperactive side too, so I am a little worried to try it. angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 You can give up to 20 mg of histidine per pound of kid. You should start at 1 or 2 mg per pound and work your way up to find the point where you get the best response. Andy . .. . . . .. . . . . . . > Do you give the same doseage of histidine as carnosine? My 6 yr old > son is up to 125 mg 2x/day of carnosine. I truely love this stuff but > he is a little more " energetic. " I might want to try switching to the > histidine once we've used the carnosine up. > > > > > > Actually, carnosine is made up of histidine and alanine. Some > prefer > > histidine over carnosine because they believe it is the beneficial > > half and because they also believe it is the alanine that causes > some > > kids to be hyper on carnosine. We started on carnosine, and > he > > did get a little jumpy, and slightly more talkative. When we > > switched to histidine, he didn't back pedal on talkative, but he > did > > dial it down a notch or two on his jumpiness. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 is there a web site for l carnosine. I can't find it anywhere. angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 I did just buy the Carnosine, it is expensive, almost 50. 00 at the health food store. My son is on the hyperactive side too, so I am a little worried to try it. angela You can buy carnosine for much less at www.beyondacentury.com It comes in powder form, so you'd have to measure out the doses by yourself. Sheryl Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 Carn-aware site is www.carn-aware.com. Here is another piece I found. Valeri Autism Breakthrough By Dr. Breen Chicago Monday, October 07, 2002 10:03 AM There has been a major breakthrough in the treatment of autism. A supplement that you can get at health food stores has been shown to make a major difference. Dr. Breen reports the details. Parents with autistic children are saying that a natural compound in a person's body called carnosine have helped their kids. Carnosine combines with transmitters deep in the brain. Rose Stodola a mother of autistic child said, " Almost immediately within the first week I noticed a change. " " The gym teacher came up to me and said my gosh he's like a different child, " added Maureen Sieger. Four-year-old Stodola would not talk to anybody. But then he took carnosine and there was a noticeable change. (Nick shakes Dr. Breen's hand.) Dr. Chez found that kind of change was typical for 80 percent of these and other autistic children. Some jumped eight months in their reading scores and their behavior also changed. He said, " Response time, and eye contact and social awareness improved, play skills improved as a general rule. " What's really exciting is because carnosine works by stabilizing and protecting brain cells and helping patients like may be just the beginning. Carnosine may help patients with Alzheimer's, an illness similar to autism and it has already helped some Alzheimer patients. Carnosine's also helped some other children. Dr. Chez said, " We've had parents report improved reading skills with dyslexic tendencies...just improved test scores with kids who've had borderline attention disorder. " Soon other parents may have the same reaction ' have. " Carnoware and Dr. Chez have given us our son back, " said Stodola. Dr. Breen says some non-autistic adults claim carnosine makes them more alert and improves their memory. Dr. Chez Autism and Epilepsy Center Lake Bluff, IL 847-735-0300 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 17, 2002 Report Share Posted October 17, 2002 <PRE>I'm going to stop it. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 18, 2002 Report Share Posted October 18, 2002 can i ask you about brainchild nutritionals? how are you getting your child to take the vitamins? my daughter fights me alot on them! they are no better tasting than the super nu thera! the minerals are easy to hide! keri Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 18, 2002 Report Share Posted October 18, 2002 Are we giving other supplements? Boy... do we ever! 's primary source of folic acid and B-12 actually comes from the BrainChild Nutritionals Spectrum Support II we give him. In addition to this he gets a bunch of other stuff, e.g. C, E, Milk Thistle, NAG, Citramin II, Calcium, Zinc, Magnesium Glycinate, Idebenone, Chelation Pro Aid Support, Glutamine, Melatonin, probiotics, enzymes, nystatin (for the next couple of months), Bethanochol, calcium butyrate, alpha- keto glutarate, and maybe a couple of others that I don't recall at the moment. The dosing seems pretty daunting at first, but it's not as bad as it sounds. My parents will be watching next weekend while DW and I go to the San Diego DAN!, and they're a little intimadated, but a prep visit this weekend will hopefully soothe their worries. Max in VA > In a message dated 10/17/02 7:09:01 AM Pacific Daylight Time, > msalinas@y... writes: > > << > > I actually have my son on L-Histidine which the body uses to make L- > > Carnosine. It is cheaper and less potent. I heard that L- > Carnosine > > could cause hyperactivity so I started with the lesser of the two > > although I have a bottle of L-Carnosine that I plan to use when my > > Histidine runs out. > > Dosing - I give 500 mg L-Histidine twice a day on an empty (or the > > best we can do) tummy. Because Carn-aware has Selenium and Vitamin > > E (am I remembering this right?) I also give him these. I can't be > > sure it is helping him, I have also recently started giving him > Milk > >> > hi thanks for your response. Are you giving anyother supplements like folic > acid and b-12? > I did just buy the Carnosine, it is expensive, almost 50. 00 at the health > food store. My son is on the hyperactive side too, so I am a little worried > to try it. > angela Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 18, 2002 Report Share Posted October 18, 2002 We use 200 mg twice a day. My son is 33 lbs. Theresa Quote Link to comment Share on other sites More sharing options...
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