ecklonia cava could help asthma

[Guest guest]

Ecklonia cava (EC) is a brown alga that evidences radical scavenging

activity, bactericidal activity, tyrosinase inhibitory activity, and

protease inhibitory activity. However, its anti-allergic effects remain

poorly understood. In the current study, we attempted to determine

whether pretreatment with EC induces a significant inhibition of

asthmatic reactions in a mouse asthma model. Mice sensitized and

challenged with ovalbumin (OVA) evidenced typical asthmatic reactions,

as follows: an increase in the number of eosinophils in bronchoalveolar

lavage fluid; a marked influx of inflammatory cells into the lung around

blood vessels and airways, and airway luminal narrowing; the development

of airway hyperresponsiveness; the detection of tumor necrosis

factor-alpha (TNF-alpha) and Th2 cytokines, including IL-4 and IL-5 in

the bronchoalveolar lavage (BAL) fluid; and the detection of

allergen-specific immunoglobulin E (IgE) in the serum. However, the

administration of EC extract prior to the final airway OVA challenge

resulted in a significant inhibition of all asthmatic reactions. We also

demonstrated that EC extracts treatment resulted in significant

reductions on matrix metalloproteinase-9 (MMP-9) and Suppressor of

cytokine signaling-3 (SOCS-3) expression and a reduction in the

increased eosinophil peroxidase (EPO) activity. The treatment of animals

with EC extracts resulted in a significant reduction in the

concentrations of the Th2 cytokine (IL-4 and IL-5) in the airways,

without any concomitant increase in the concentration of Th1 cytokines.

These findings indicate that EC extracts may prove useful as an adjuvant

therapy for allergic airway reactions via the inhibition of the Th2

response. Accordingly, this study may provide evidence that EC extract

performs a critical function in the amelioration of the pathogenetic

process of asthma in mice.

[Guest guest]

Wow, this is great information! What do you think are differences

between Modifilan and Ecklonia cava? I just read some on the

Ecklonia cava and it said it helps greatly with ATP which is

definitely a main problem in the autism community. I can't wait to

find the time to research some more on this, learn the difference

between Modifilan and Ecklonia Cava and try the Ecklonia Cava out. I

started taking Modifilan about 10 days or so ago, and it is

wonderful! I feel more in-tuned I guess. Its difficult to describe,

but I just love it.

Love and prayers,

Heidi N

>

> Ecklonia cava (EC) is a brown alga that evidences radical scavenging

> activity, bactericidal activity, tyrosinase inhibitory activity, and

> protease inhibitory activity. However, its anti-allergic effects

remain

> poorly understood. In the current study, we attempted to determine

> whether pretreatment with EC induces a significant inhibition of

> asthmatic reactions in a mouse asthma model. Mice sensitized and

> challenged with ovalbumin (OVA) evidenced typical asthmatic

reactions,

> as follows: an increase in the number of eosinophils in

bronchoalveolar

> lavage fluid; a marked influx of inflammatory cells into the lung

around

> blood vessels and airways, and airway luminal narrowing; the

development

> of airway hyperresponsiveness; the detection of tumor necrosis

> factor-alpha (TNF-alpha) and Th2 cytokines, including IL-4 and IL-5

in

> the bronchoalveolar lavage (BAL) fluid; and the detection of

> allergen-specific immunoglobulin E (IgE) in the serum. However, the

> administration of EC extract prior to the final airway OVA challenge

> resulted in a significant inhibition of all asthmatic reactions. We

also

> demonstrated that EC extracts treatment resulted in significant

> reductions on matrix metalloproteinase-9 (MMP-9) and Suppressor of

> cytokine signaling-3 (SOCS-3) expression and a reduction in the

> increased eosinophil peroxidase (EPO) activity. The treatment of

animals

> with EC extracts resulted in a significant reduction in the

> concentrations of the Th2 cytokine (IL-4 and IL-5) in the airways,

> without any concomitant increase in the concentration of Th1

cytokines.

> These findings indicate that EC extracts may prove useful as an

adjuvant

> therapy for allergic airway reactions via the inhibition of the Th2

> response. Accordingly, this study may provide evidence that EC

extract

> performs a critical function in the amelioration of the pathogenetic

> process of asthma in mice.

>