ChromeMate(R) Favorably Influences Genes That Promote Muscle Development, Burnin

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ChromeMate® Favorably Influences Genes That Promote Muscle

Development, Burning Of Brown Fat

http://www.medicalnewstoday.com/medicalnews.php?newsid=61314

In a promising new study, researchers at Ohio State University

Medical Center have shown that ChromeMate® affects fat metabolism

and muscle activity at the genetic level.

ChromeMate, produced by InterHealth Nutraceuticals, is an oxygen-

coordinated niacin-bound form of supplemental chromium that has

previously been shown to promote healthy glucose metabolism and

lipid profiles, as well as lean body mass. It has been affirmed GRAS

(Generally Recognized as Safe) for use in functional beverages.

In this new study, researchers looked at the effect that ChromeMate

might have on risk factors involved in Metabolic Syndrome, a cluster

of symptoms that can include abdominal obesity, inefficient insulin

action, high triglyceride and LDL ( " bad " ) cholesterol levels, and

low levels of HDL ( " good " ) cholesterol. Metabolic Syndrome can

increase the risk of developing cardiovascular disease and type-2

diabetes.

The results of the new study showed that ChromeMate positively

influenced the expression of numerous genes involved in fat

metabolism and muscle development. The study, recently published in

Physiology Genomics, was conducted with Lepr-db mice, which are born

obese and diabetic and are a useful model for studying Metabolic

Syndrome. The Lepr-db mice typically suffer from abnormally high

blood glucose and lipid profiles beginning at 30 days of life.

Researchers investigated the effects of ChromeMate versus placebo on

the subcutaneous fat tissue (the fat tissue that lies under the

second layer of the skin) of the animals by means of Gene Microarray

Analysis, using more than 45,000 sets of mouse genome.

ChromeMate improves muscle development, burning of brown fat tissue

ChromeMate up-regulated (activated) the expression of four muscle-

specific genes within the subcutaneous fat. These genes provide the

signal for pre-adipocytes (fat precursor cells) to produce muscle

instead of fat cells. These findings corroborate earlier studies

showing that ChromeMate enhances the production of lean body mass.

ChromeMate down-regulated (de-activated) genes that encode (possess

genetic information) for CIDEA and UCP1, which are key components in

brown fat tissue thermogenesis, or the burning of fat for heat

production. CIDEA is considered a " candidate " gene for obesity;

mice that do not possess this gene are resistant to diet-induced

obesity and diabetes. ChromeMate also down-regulated TTP, a gene

that provides antioxidant support to all tissues for survival, in

the subcutaneous fat. Therefore, ChromeMate stops antioxidant

support to the subcutaneous fat tissues and ultimately kills the fat

cells.

" We were very pleased with these findings, " said Debasis Bagchi,

Ph.D., F.A.C.N., Senior Vice President of Research and Development

for InterHealth. " The down-regulation of CIDEA and UCP1 is

particularly heartening, because of their specific role related to

obesity and because brown fat is the most difficult type of fat for

people to lose. These results tell us that supplementation may in

fact help individuals who are predisposed to having a problem losing

brown fat tissue, " Dr. Bagchi added.

Dr. Bagchi also pointed out that ChromeMate influenced only a small

select percentage of the genes screened, signifying that the

supplement's effect was limited to genes that it could positively

impact and did not affect genes that could alter normal body

functions or be considered indicators of toxicity in the body.

ChromeMate improves lipid profiles

& #8232;Prior to conducting the gene expression tests, researchers

investigated the effects of ChromeMate supplementation versus

placebo on blood lipid and glucose profiles in the Lepr-db mice. The

findings corroborated previous studies showing that ChromeMate

improved blood lipids and increased the clearance of glucose from

the bloodstream. ChromeMate significantly lowered total cholesterol,

LDL cholesterol and triglyceride levels, and increased the level of

HDL cholesterol. In addition, blood glucose cleared more rapidly in

response to an oral glucose tolerance test.