Guest guest Posted February 8, 2007 Report Share Posted February 8, 2007 Gretchen, I have a question in your response you said that there is research saying that 2nd generation CMT can show worse symptoms - does that mean that in each generation it could be worse. My son is at least a 4th generation CMTer and his symptoms seem much worse then previous generations . I have always read it can vary with in families but I was curious about the research after reading your post. - Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2007 Report Share Posted February 8, 2007 Hi , Some research I read some time ago mentioned the 2nd generation CMT could show more severe symptoms. Give me awhile to remember where that was and I'll post it. (just need to go through my files) As for 4th generation, I really can't say, but if that 2nd generation " theory " holds true, then it's possible. Yes, too, that it is true that symptoms can vary in families where CMT is present throughout. ~ Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2007 Report Share Posted February 8, 2007 I have two children with mild symptoms (compared to mine). A third child with more involved CMT than my own. My children are second generation CMT. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2007 Report Share Posted February 9, 2007 Hi, I'm not sure what generation I would be, I know my great-grandfather had CMT. My Dad's symptoms are a lot more severe than his mother's - Grannie didn't really have any symptoms except her thumb and everyone swears that was from a sticker working its way into the bone and messing it up - mine's doing the same thing, so I think it was from the CMT. From what I understand, dad's symptoms are less severe than his grandfathers - either that or he's a lot more stubborn. His grandfather wound up in a wheelchair later in life. My dad still walks, although at times, I'm not sure how. My dad really doesn't have any calf muscles, but does have quad muscles. His legs are like sticks from ankle to knee. He has AFOs and uses needlenose pliers for his fingers and can't straighten his hands out. He had surgery when he was in high school to staple his ankle - he was walking on the top of his feet - severe foot drop. None of us girls have symptoms that severe or as severe as his were at our current ages. My middle daughter will probably be more severe than I am. My oldest will probably be less severe. One sister's sons will probably be worse than she is. My youngest sister's children are 5- 8 yrs old and so far aren't exhibiting any symptoms that I know of. My youngest sister is the one with the worst symptoms of my generation. I think the severity of the symptoms are related to the individual and have nothing to do with what generation of CMT. Tonya Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 24, 2007 Report Share Posted February 24, 2007 I agree with the post from Tonya. My doctor's told me that with 1A the severity was not genetically multiplied, however they did say other neuropathy such as Freidrich's Ataxia did have a multiplier effect. I think it is down to the individual gene impacted and the way that when a sperm and egg combine what happens to the resulting full DNA strand. In everything with CMT I find there is no general statement as to how symptoms manifest. I have non existent nerve velocity yet can walk and bike and swim no problems with no fatigue except for being unfit! Donna from London Quote Link to comment Share on other sites More sharing options...
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