Progesterone Antagonist Therapy & CMT

[Guest guest]

As I sit here 8 months pregnant with obviously high levels of

progesterone in my body, I began to wonder about the role of

progesterone levels and CMT.

I understand that there is research being done using progesterone

blockers on CMT1A and if I am understanding it correctly, the

decreased levels of progesterone lessened the severity/progression

of the disease.

My question is: if progesterone is the regulator of the PMP22 gene,

would it also be the regulator of other genes...specifically, the

LITAF/SIMPLE gene. (This is the gene that they found a mutation in

me which currently lables me as one of the few, but lucky " CMT1C "

folks.

I have read that CMT1C appears to be clinically identical to CMT1A,

even though there are two different genes involved. Does this mean

that anti-progesterone treatment might help someone with CMT1C too?

Does it mean that the Vitamin C treatment might help someone with

CMT1C?

My CMT was " activated " and progressed RAPIDLY while I was pregnant

with my first child. Three years later, I am pregnant with a second

baby and have not noticed any progression/exacerbation during this

pregnancy, though I know that my progesterone levels are high.

Can't help but see a strong link here.

If anyone has info on this, PLEASE ADVISE! THANKS!!!! Amy