The effect of alpha-Tocopherol supplementation on training-induced elevation of

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Clin Biochem. 2007 Aug;40(12):900-6.

(this is about Vitamin E - note last line)

The effect of alpha-Tocopherol supplementation on training-induced

elevation of S100B protein in sera of basketball players.

Schulpis KH, Moukas M, Parthimos T, Tsakiris T, Parthimos N,

Tsakiris S.

Institute of Child Health, Research Center, Aghia Sophia Children's

Hospital, GR-11527, Athens, Greece.

OBJECTIVE: To investigate the effect of alpha-Tocopherol (alpha-T)

supplementation on S100B elevated serum levels in basketball

players' training.

DESIGN: Blood was obtained from 10 basketball players pre-exercise

(group A), post-exercise (group and after 30 days on alpha-T (200

mg/24 h orally) supplementation pre- (group C) and post-training

(group D). Blood samples were taken for the evaluation of total

antioxidant status (TAS), alpha-T and catecholamines in plasma and

S100B and muscle enzyme levels in serum.

METHODS: TAS, muscle enzymes: creatine kinase (CK), lactate

dehydrogenase (LDH), and S100B protein levels were measured with

commercial kits, whereas alpha-T and catecholamine levels with HPLC

methods.

RESULTS: TAS was found higher in the groups with alpha-T addition

(groups C and D) than in the other ones. On the contrary, CK, LDH

and S100B were remarkably lower (116.8+9.5 U/L, 427+22 U/L,

0.18+0.04 microg/L, respectively) in group D than those in group B

(286+12 U/L, 688+26 U/L, 0.28+0.06 microg/L, p<0.001, respectively).

S100B levels were negatively correlated with TAS (r=-0.64, p<0.001)

and positively with CK levels (r=0.58, p<0.001).

CONCLUSIONS: alpha-T supplementation may reduce S100B increased

release from muscle and nerves induced by training. S100B serum

evaluation may be a useful biomarker for the effect of training on

the participation of the neuromuscular system.