Re: Symptoms and Thanks (PA effect on GFR)

[Guest guest]

I found this study that may shed some light on current discussion:

Risk Factors Associated with a Low Glomerular Filtration Rate in Primary

Aldosteronism

source: http://jcem.endojournals.org/content/94/3/869.full

" Conclusions: In a large cohort of patients with PA, markers of disease activity

such as plasma aldosterone and serum potassium are independent predictors of a

lower GFR. Specific interventions, such as adrenalectomy or spironolactone

treatment, are associated with a further decline in GFR. "

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with DASH. 2-Day ave w/o meds = BP 133/77 HR 61 BS 132. D/C

Spironolactone 12/20/2011 due to adverse SX.

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD

and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg aspirin and

Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> > According to your analyses and

> > symptoms, it seems that you

> > > > > > > > > > > > > > >> have the same Conn's that most of us

> > have. Start to Dash

> > > > > > > > > > > > > > >> IMMEDIATELY, if you feel better and if

> > you are not afraid, try

> > > > > > > > > > > > > > >> spiro or eplerenone, even small dosage.

> > If your BP behaves better

> > > > > > > > > > > > > > >> with this medication, that's it! Don't

> > wait 6 months until your

> > > > > > > > > > > > > > >> appointment and some more years until you

> > are going to be

> > > > > > > > > > > > > > >> diagnosed. Some of us, including myself,

> > are still undiagnosed

> > > > > > > > > > > > > > >> after several years and many doctors.

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> > Â

> > > > > > > > > > > > > > >> > >> > Natalia Kamneva 67 Russian F with

> > 2 cm left adrenal adenoma,

> > > > > > > > > > > > > > >> diabetic; on 100 mg eplerenone, 80 mg

> > Micardis, 2000 mg metformin,

> > > > > > > > > > > > > > >> 60 mg Dexilant and 2 mg Lorazepam;

> > Dashing; still have some

> > > > > > > > > > > > > > >> occasional problems with BP, K and Na

> > when over-salt eplerenone ;

> > > > > > > > > > > > > > >> on private consultation with Dr Grim.

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> > ________________________________

> > > > > > > > > > > > > > >> > >> > From: lff_409 <.>

> > > > > > > > > > > > > > >> > >> > To:

> > > > > > > > > > > > > > >> > >> > Sent: Monday, January 2, 2012 1:45

> > PM

> > > > > > > > > > > > > > >> > >> > Subject:

> > Symptoms and Thanks

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> > Â

> > > > > > > > > > > > > > >> > >> > First of all, thanks to all that

> > responded.

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >> > My GP sent me to the Endo for new

> > sudden onset hypertension,

> > > > > > > > > > > > > > >> slightly Low K (3.1), heat intolerance,

> > weakness, tachycardia,

> > > > > > > > > > > > > > >> headache, fatigue, and emotional swings.

> > I am a 58 yo male, retired

> > > > > > > > > > > > > > >> firefighter. Only other medical Hx is

> > small Pineal gland tumor and

> > > > > > > > > > > > > > >> hashimoto thyroiditis controlled with

> > synthesis for past 20 years.

> > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > >> > >>

> > > > > > > > > > > > > > >> > >>

> > > > > > > > > > > > > > >> > >>

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>

[Guest guest]

Nice article but should have used eGFR as that adjusts for age a bit.I sent them a note.Should add to our files. Renal function in PA. Thanks.CE Grim MD I found this study that may shed some light on current discussion: Risk Factors Associated with a Low Glomerular Filtration Rate in Primary Aldosteronism source: http://jcem.endojournals.org/content/94/3/869.full "Conclusions: In a large cohort of patients with PA, markers of disease activity such as plasma aldosterone and serum potassium are independent predictors of a lower GFR. Specific interventions, such as adrenalectomy or spironolactone treatment, are associated with a further decline in GFR." - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. 2-Day ave w/o meds = BP 133/77 HR 61 BS 132. D/C Spironolactone 12/20/2011 due to adverse SX. Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > According to your analyses and > > symptoms, it seems that you > > > > > > > > > > > > > > >> have the same Conn's that most of us > > have. Start to Dash > > > > > > > > > > > > > > >> IMMEDIATELY, if you feel better and if > > you are not afraid, try > > > > > > > > > > > > > > >> spiro or eplerenone, even small dosage. > > If your BP behaves better > > > > > > > > > > > > > > >> with this medication, that's it! Don't > > wait 6 months until your > > > > > > > > > > > > > > >> appointment and some more years until you > > are going to be > > > > > > > > > > > > > > >> diagnosed. Some of us, including myself, > > are still undiagnosed > > > > > > > > > > > > > > >> after several years and many doctors. > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > Â > > > > > > > > > > > > > > >> > >> > Natalia Kamneva 67 Russian F with > > 2 cm left adrenal adenoma, > > > > > > > > > > > > > > >> diabetic; on 100 mg eplerenone, 80 mg > > Micardis, 2000 mg metformin, > > > > > > > > > > > > > > >> 60 mg Dexilant and 2 mg Lorazepam; > > Dashing; still have some > > > > > > > > > > > > > > >> occasional problems with BP, K and Na > > when over-salt eplerenone ; > > > > > > > > > > > > > > >> on private consultation with Dr Grim. > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > ________________________________ > > > > > > > > > > > > > > >> > >> > From: lff_409 <.> > > > > > > > > > > > > > > >> > >> > To: > > > > > > > > > > > > > > >> > >> > Sent: Monday, January 2, 2012 1:45 > > PM > > > > > > > > > > > > > > >> > >> > Subject: > > Symptoms and Thanks > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > Â > > > > > > > > > > > > > > >> > >> > First of all, thanks to all that > > responded. > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > My GP sent me to the Endo for new > > sudden onset hypertension, > > > > > > > > > > > > > > >> slightly Low K (3.1), heat intolerance, > > weakness, tachycardia, > > > > > > > > > > > > > > >> headache, fatigue, and emotional swings. > > I am a 58 yo male, retired > > > > > > > > > > > > > > >> firefighter. Only other medical Hx is > > small Pineal gland tumor and > > > > > > > > > > > > > > >> hashimoto thyroiditis controlled with > > synthesis for past 20 years. > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > >> > >> > > > > > > > > > > > > > > >> > > > > > > > > > > > > > > > >> > > > > > > > > > > > > > > >> > > > > > > > > > > > > > > >> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > >

[Guest guest]

Downloaded...JC.

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> > According to your analyses and

> > > > symptoms, it seems that you

> > > > > > > > > > > > > > > > >> have the same Conn's that most of us

> > > > have. Start to Dash

> > > > > > > > > > > > > > > > >> IMMEDIATELY, if you feel better and if

> > > > you are not afraid, try

> > > > > > > > > > > > > > > > >> spiro or eplerenone, even small dosage.

> > > > If your BP behaves better

> > > > > > > > > > > > > > > > >> with this medication, that's it! Don't

> > > > wait 6 months until your

> > > > > > > > > > > > > > > > >> appointment and some more years until

> > you

> > > > are going to be

> > > > > > > > > > > > > > > > >> diagnosed. Some of us, including

> > myself,

> > > > are still undiagnosed

> > > > > > > > > > > > > > > > >> after several years and many doctors.

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> > Â

> > > > > > > > > > > > > > > > >> > >> > Natalia Kamneva 67 Russian F

> > with

> > > > 2 cm left adrenal adenoma,

> > > > > > > > > > > > > > > > >> diabetic; on 100 mg eplerenone, 80 mg

> > > > Micardis, 2000 mg metformin,

> > > > > > > > > > > > > > > > >> 60 mg Dexilant and 2 mg Lorazepam;

> > > > Dashing; still have some

> > > > > > > > > > > > > > > > >> occasional problems with BP, K and Na

> > > > when over-salt eplerenone ;

> > > > > > > > > > > > > > > > >> on private consultation with Dr Grim.

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> > ________________________________

> > > > > > > > > > > > > > > > >> > >> > From: lff_409 <.>

> > > > > > > > > > > > > > > > >> > >> > To:

> > > > > > > > > > > > > > > > >> > >> > Sent: Monday, January 2, 2012

> > 1:45

> > > > PM

> > > > > > > > > > > > > > > > >> > >> > Subject:

> > > > Symptoms and Thanks

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> > Â

> > > > > > > > > > > > > > > > >> > >> > First of all, thanks to all that

> > > > responded.

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >> > My GP sent me to the Endo for

> > new

> > > > sudden onset hypertension,

> > > > > > > > > > > > > > > > >> slightly Low K (3.1), heat intolerance,

> > > > weakness, tachycardia,

> > > > > > > > > > > > > > > > >> headache, fatigue, and emotional

> > swings.

> > > > I am a 58 yo male, retired

> > > > > > > > > > > > > > > > >> firefighter. Only other medical Hx is

> > > > small Pineal gland tumor and

> > > > > > > > > > > > > > > > >> hashimoto thyroiditis controlled with

> > > > synthesis for past 20 years.

> > > > > > > > > > > > > > > > >> > >> >

> > > > > > > > > > > > > > > > >> > >>

> > > > > > > > > > > > > > > > >> > >>

> > > > > > > > > > > > > > > > >> > >>

> > > > > > > > > > > > > > > > >> > >>

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