Spironolactone Side Effects, Is It Right For You?

[Guest guest]

Beware of support sites recommended off label use of drugs. I would recommend the group set up proper trial to test the long term benefits and possible risks of what they are being recommended to take. I would start with pubmed searches first. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

But all anti-androgens are far from a panacea. One should realize that the bulk of these preparations used in transgender medicine are comprised of drugs that produce an anti-androgenic effect incidental to their designed purpose. The anti-androgens that some transgender patients are taking, are being taken by many others for a variety of very different medical conditions that include anti-hypertensive treatment (reducing high blood pressure), treating prostactic cancer, prostatic enlargement, and fungal conditions, amongst others. And as common sense would dictate, these drugs with their wide scope of uses may also produce a wide variety of potentially serious side effects. For example, a particular drug when used in treating cancer may work within acceptable limits of overall risk, even though it produces a certain stain on the liver. But when the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to an otherwise healthy individual, are the mild

feminizing effects of this mediation worth the potentially serious health risks associated with its use? This is the question the transgender patient should consider, and naturally, the physician entrusted with the care of that individual is also considering.

Looks like at the minimum we should decide if we want to go the transgender route. I know at one point it was asked if spironolactone was used for sex changes and the answer was "Not that I am aware of" if memory serves me right. I can now say it is the medicine of choice dosed at 100 to 200 mg along with a supplemental estrogen medicine according to atleast one support site!

.....

[Guest guest]

Is Elperenone " on label " for PA?

>

> > But all anti-androgens are far from a panacea. One should realize that the

bulk of these preparations used in transgender medicine are comprised of drugs

that produce an anti-androgenic effect incidental to their designed purpose. The

anti-androgens that some transgender patients are taking, are being taken by

many others for a variety of very different medical conditions that include

anti-hypertensive treatment (reducing high blood pressure), treating prostactic

cancer, prostatic enlargement, and fungal conditions, amongst others. And as

common sense would dictate, these drugs with their wide scope of uses may also

produce a wide variety of potentially serious side effects. For example, a

particular drug when used in treating cancer may work within acceptable limits

of overall risk, even though it produces a certain stain on the liver. But when

the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to

an otherwise healthy individual, are the mild feminizing effects of this

mediation worth the potentially serious health risks associated with its use?

This is the question the transgender patient should consider, and naturally, the

physician entrusted with the care of that individual is also considering.

> >

> > Looks like at the minimum we should decide if we want to go the transgender

route. I know at one point it was asked if spironolactone was used for sex

changes and the answer was " Not that I am aware of " if memory serves me right. I

can now say it is the medicine of choice dosed at 100 to 200 mg along with a

supplemental estrogen medicine according to atleast one support site!

> >

> > ....

> >

> >

>

[Guest guest]

Did you have an opportunity to review the site prior to this comment. I suppose

they could be Quacks and not who they say they are but I doubt it. Here is

their title on their home page and they claim to have links to 1300 links to

other sites that deal with the subject. I have reviewed only the home site so

far and could relate to a lot of what they were talking about.

Specialists in the Medical & Psychological Aspects of Transgender Health Care

Carl W. Bushong, Ph.D., LMFT

A. , Jr., M.D., FACEP

L. Westwood, CPE, CCE

et al.

>

> > But all anti-androgens are far from a panacea. One should realize that the

bulk of these preparations used in transgender medicine are comprised of drugs

that produce an anti-androgenic effect incidental to their designed purpose. The

anti-androgens that some transgender patients are taking, are being taken by

many others for a variety of very different medical conditions that include

anti-hypertensive treatment (reducing high blood pressure), treating prostactic

cancer, prostatic enlargement, and fungal conditions, amongst others. And as

common sense would dictate, these drugs with their wide scope of uses may also

produce a wide variety of potentially serious side effects. For example, a

particular drug when used in treating cancer may work within acceptable limits

of overall risk, even though it produces a certain stain on the liver. But when

the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to

an otherwise healthy individual, are the mild feminizing effects of this

mediation worth the potentially serious health risks associated with its use?

This is the question the transgender patient should consider, and naturally, the

physician entrusted with the care of that individual is also considering.

> >

> > Looks like at the minimum we should decide if we want to go the transgender

route. I know at one point it was asked if spironolactone was used for sex

changes and the answer was " Not that I am aware of " if memory serves me right. I

can now say it is the medicine of choice dosed at 100 to 200 mg along with a

supplemental estrogen medicine according to atleast one support site!

> >

> > ....

> >

> >

>

[Guest guest]

Just for those with high blood pressure. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

Is Elperenone "on label" for PA?

>

> > But all anti-androgens are far from a panacea. One should realize that the bulk of these preparations used in transgender medicine are comprised of drugs that produce an anti-androgenic effect incidental to their designed purpose. The anti-androgens that some transgender patients are taking, are being taken by many others for a variety of very different medical conditions that include anti-hypertensive treatment (reducing high blood pressure), treating prostactic cancer, prostatic enlargement, and fungal conditions, amongst others. And as common sense would dictate, these drugs with their wide scope of uses may also produce a wide variety of potentially serious side effects. For example, a particular drug when used in treating cancer may work within acceptable limits of overall risk, even though it produces a certain stain on the liver. But when the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to an otherwise healthy individual, are the mild

feminizing effects of this mediation worth the potentially serious health risks associated with its use? This is the question the transgender patient should consider, and naturally, the physician entrusted with the care of that individual is also considering.

> >

> > Looks like at the minimum we should decide if we want to go the transgender route. I know at one point it was asked if spironolactone was used for sex changes and the answer was "Not that I am aware of" if memory serves me right. I can now say it is the medicine of choice dosed at 100 to 200 mg along with a supplemental estrogen medicine according to atleast one support site!

> >

> > ....

> >

> >

>

[Guest guest]

I did look at the first one. Their list of drugs did not list Spiro or eplere so stopped. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

Did you have an opportunity to review the site prior to this comment. I suppose they could be Quacks and not who they say they are but I doubt it. Here is their title on their home page and they claim to have links to 1300 links to other sites that deal with the subject. I have reviewed only the home site so far and could relate to a lot of what they were talking about.

Specialists in the Medical & Psychological Aspects of Transgender Health Care

Carl W. Bushong, Ph.D., LMFT

A. , Jr., M.D., FACEP

L. Westwood, CPE, CCE

et al.

>

> > But all anti-androgens are far from a panacea. One should realize that the bulk of these preparations used in transgender medicine are comprised of drugs that produce an anti-androgenic effect incidental to their designed purpose. The anti-androgens that some transgender patients are taking, are being taken by many others for a variety of very different medical conditions that include anti-hypertensive treatment (reducing high blood pressure), treating prostactic cancer, prostatic enlargement, and fungal conditions, amongst others. And as common sense would dictate, these drugs with their wide scope of uses may also produce a wide variety of potentially serious side effects. For example, a particular drug when used in treating cancer may work within acceptable limits of overall risk, even though it produces a certain stain on the liver. But when the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to an otherwise healthy individual, are the mild

feminizing effects of this mediation worth the potentially serious health risks associated with its use? This is the question the transgender patient should consider, and naturally, the physician entrusted with the care of that individual is also considering.

> >

> > Looks like at the minimum we should decide if we want to go the transgender route. I know at one point it was asked if spironolactone was used for sex changes and the answer was "Not that I am aware of" if memory serves me right. I can now say it is the medicine of choice dosed at 100 to 200 mg along with a supplemental estrogen medicine according to atleast one support site!

> >

> > ....

> >

> >

>

[Guest guest]

I only have time for pubmed mostly and even that is hard. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

Did you have an opportunity to review the site prior to this comment. I suppose they could be Quacks and not who they say they are but I doubt it. Here is their title on their home page and they claim to have links to 1300 links to other sites that deal with the subject. I have reviewed only the home site so far and could relate to a lot of what they were talking about.

Specialists in the Medical & Psychological Aspects of Transgender Health Care

Carl W. Bushong, Ph.D., LMFT

A. , Jr., M.D., FACEP

L. Westwood, CPE, CCE

et al.

>

> > But all anti-androgens are far from a panacea. One should realize that the bulk of these preparations used in transgender medicine are comprised of drugs that produce an anti-androgenic effect incidental to their designed purpose. The anti-androgens that some transgender patients are taking, are being taken by many others for a variety of very different medical conditions that include anti-hypertensive treatment (reducing high blood pressure), treating prostactic cancer, prostatic enlargement, and fungal conditions, amongst others. And as common sense would dictate, these drugs with their wide scope of uses may also produce a wide variety of potentially serious side effects. For example, a particular drug when used in treating cancer may work within acceptable limits of overall risk, even though it produces a certain stain on the liver. But when the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to an otherwise healthy individual, are the mild

feminizing effects of this mediation worth the potentially serious health risks associated with its use? This is the question the transgender patient should consider, and naturally, the physician entrusted with the care of that individual is also considering.

> >

> > Looks like at the minimum we should decide if we want to go the transgender route. I know at one point it was asked if spironolactone was used for sex changes and the answer was "Not that I am aware of" if memory serves me right. I can now say it is the medicine of choice dosed at 100 to 200 mg along with a supplemental estrogen medicine according to atleast one support site!

> >

> > ....

> >

> >

>

[Guest guest]

Okay, try this but I find it difficult to understand why you wouldn't take a

little time to review is something is contrary IMHO to what you are advocating!

If you don't have time to review my entire post, please pay particular to these

paragraphs: 3.2, 4.1, 4.3,4.4 and 4.5

OK, since you don't trust what on-line support groups recommend, remind me what

this group is, let's try this:

All quotes are from: http://jcem.endojournals.org/content/94/9/3132.full which I

found on Pubmed.

Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical

Practice Guideline

Wylie C. Hembree,

Peggy Cohen-Kettenis,

Henriette A. Delemarre-van de Waal,

Louis J. Gooren,

Walter J. Meyer III,

Norman P. Spack,

Vin Tangpricha and

Victor M. Montori1

- Author Affiliations

Columbia University and New York Presbyterian Hospital (W.C.H.), New York, New

York 10032; VU Medical Center (P.C-K., H.A.D.-v.d.W.), 1007 MB Amsterdam, The

Netherlands; Leiden University Medical Center (H.A.D.-v.d.W.), 2300 RC Leiden,

The Netherlands; Andro-consult (L.J.G.) ChaingMai 50220, Thailand; University of

Texas Medical Branch (W.J.M.), Galveston, Texas 77555; Harvard Medical School

(N.P.S.), Boston, Massachusetts 02115; Emory University School of Medicine

(V.T.), Atlanta, Georgia 30322; and Mayo Clinic (V.M.M.), Rochester, Minnesota

55905

3.0 Hormonal therapy for transsexual adults

3.1 We recommend that treating endocrinologists confirm the diagnostic criteria

of GID or transsexualism and the eligibility and readiness criteria for the

endocrine phase of gender transition. (1 ¨'¨'¨'¡ð)

3.2 We recommend that medical conditions that can be exacerbated by hormone

depletion and cross-sex hormone treatment be evaluated and addressed prior to

initiation of treatment (see Table 11 & #8659;: Medical conditions that can be

exacerbated by cross-sex hormone therapy). (1 ¨'¨'¨'¡ð)

3.3 We suggest that cross-sex hormone levels be maintained in the normal

physiological range for the desired gender. (2 ¨'¨'¡ð¡ð)

3.4 We suggest that endocrinologists review the onset and time course of

physical changes induced by cross-sex hormone treatment. (2 ¨'¨'¡ð¡ð)

4.0 Adverse outcome prevention and long-term care

4.1 We suggest regular clinical and laboratory monitoring every 3 months during

the first year and then once or twice yearly. (2 ¨'¨'¡ð¡ð)

4.2 We suggest monitoring prolactin levels in male-to-female (MTF) transsexual

persons treated with estrogens. (2 ¨'¨'¡ð¡ð)

4.3 We suggest that transsexual persons treated with hormones be evaluated for

cardiovascular risk factors. (2 ¨'¨'¡ð¡ð)

4.4 We suggest that bone mineral density (BMD) measurements be obtained if risk

factors for osteoporosis exist, specifically in those who stop hormone therapy

after gonadectomy. (2 ¨'¨'¨'¡ð)

4.5 We suggest that MTF transsexual persons who have no known increased risk of

breast cancer follow breast screening guidelines recommended for biological

women. (2 ¨'¨'¡ð¡ð)

4.6 We suggest that MTF transsexual persons treated with estrogens follow

screening guidelines for prostatic disease and prostate cancer recommended for

biological men. (2 ¨'¡ð¡ð¡ð)

4.7 We suggest that female-to-male (FTM) transsexual persons evaluate the risks

and benefits of including total hysterectomy and oophorectomy as part of sex

reassignment surgery. (2 ¨'¡ð¡ð¡ð)

Some of this doesn¡¯t apply but I didn¡¯t want to explain gaps! With these

recommendations when Spironolactone is considered one of the primary medicines

for this purpose, wouldn¡¯t it make sense whenever one is using the drug for

whatever purpose? I suspect side effects are not unique to only that disease!

.....

> > >

> > > > But all anti-androgens are far from a panacea. One should realize that

the bulk of these preparations used in transgender medicine are comprised of

drugs that produce an anti-androgenic effect incidental to their designed

purpose. The anti-androgens that some transgender patients are taking, are being

taken by many others for a variety of very different medical conditions that

include anti-hypertensive treatment (reducing high blood pressure), treating

prostactic cancer, prostatic enlargement, and fungal conditions, amongst others.

And as common sense would dictate, these drugs with their wide scope of uses may

also produce a wide variety of potentially serious side effects. For example, a

particular drug when used in treating cancer may work within acceptable limits

of overall risk, even though it produces a certain stain on the liver. But when

the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to

an otherwise healthy individual, are the mild feminizing effects of this

mediation worth the potentially serious health risks associated with its use?

This is the question the transgender patient should consider, and naturally, the

physician entrusted with the care of that individual is also considering.

> > > >

> > > > Looks like at the minimum we should decide if we want to go the

transgender route. I know at one point it was asked if spironolactone was used

for sex changes and the answer was " Not that I am aware of " if memory serves me

right. I can now say it is the medicine of choice dosed at 100 to 200 mg along

with a supplemental estrogen medicine according to atleast one support site!

> > > >

> > > > ....

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

Does this make it easier for you (I was afraid you would require the background

information).

Maybe the ASH group would consider something like this for treating people

w/Spironolactone. It probably applies to more than PA and HTN! (Obviously some

of the numbers need to change if one is an unwilling participant of a gender

change!

TABLE 15.

Monitoring of MTF transsexual persons on cross-hormone therapy

1. Evaluate patient every 2–3 months in the first year and then 1–2 times per

year afterward to monitor for appropriate signs of feminization and for

development of adverse reactions.

2. Measure serum testosterone and estradiol every 3 months.

& #8195; & #8195; & #8195; & #8195;a. Serum testosterone levels should be <55 ng/dl.

& #8195; & #8195; & #8195; & #8195;b. Serum estradiol should not exceed the peak

physiological range for young healthy females, with ideal levels <200 pg/ml.

& #8195; & #8195; & #8195; & #8195;c. Doses of estrogen should be adjusted according to

the serum levels of estradiol.

3. For individuals on spironolactone, serum electrolytes (particularly

potassium) should be monitored every 2–3 months initially in the first year.

4. Routine cancer screening is recommended in nontranssexual individuals

(breasts, colon, prostate).

5. Consider BMD testing at baseline if risk factors for osteoporotic fracture

are present (e.g. previous fracture, family history, glucocorticoid use,

prolonged hypogonadism). In individuals at low risk, screening for osteoporosis

should be conducted at age 60 and in those who are not compliant with hormone

therapy.

This Article

Published online before print June 9, 2009, doi: 10.1210/jc.2009-0345 The

Journal of Clinical Endocrinology & Metabolism September 1, 2009 vol. 94 no. 9

3132-3154

AbstractFree

Full TextFree

Full Text (PDF)

> > >

> > > > But all anti-androgens are far from a panacea. One should realize that

the bulk of these preparations used in transgender medicine are comprised of

drugs that produce an anti-androgenic effect incidental to their designed

purpose. The anti-androgens that some transgender patients are taking, are being

taken by many others for a variety of very different medical conditions that

include anti-hypertensive treatment (reducing high blood pressure), treating

prostactic cancer, prostatic enlargement, and fungal conditions, amongst others.

And as common sense would dictate, these drugs with their wide scope of uses may

also produce a wide variety of potentially serious side effects. For example, a

particular drug when used in treating cancer may work within acceptable limits

of overall risk, even though it produces a certain stain on the liver. But when

the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to

an otherwise healthy individual, are the mild feminizing effects of this

mediation worth the potentially serious health risks associated with its use?

This is the question the transgender patient should consider, and naturally, the

physician entrusted with the care of that individual is also considering.

> > > >

> > > > Looks like at the minimum we should decide if we want to go the

transgender route. I know at one point it was asked if spironolactone was used

for sex changes and the answer was " Not that I am aware of " if memory serves me

right. I can now say it is the medicine of choice dosed at 100 to 200 mg along

with a supplemental estrogen medicine according to atleast one support site!

> > > >

> > > > ....

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

Not sure what list you looked at, I found Spiro mentioned in multiple places on

that site. As for Eplere, IMHO it would not be an appropriate medicine for a

M2F transgender change since as I understand it there is less hormonal impact

with it as I understand it!

.....

> > >

> > > > But all anti-androgens are far from a panacea. One should realize that

the bulk of these preparations used in transgender medicine are comprised of

drugs that produce an anti-androgenic effect incidental to their designed

purpose. The anti-androgens that some transgender patients are taking, are being

taken by many others for a variety of very different medical conditions that

include anti-hypertensive treatment (reducing high blood pressure), treating

prostactic cancer, prostatic enlargement, and fungal conditions, amongst others.

And as common sense would dictate, these drugs with their wide scope of uses may

also produce a wide variety of potentially serious side effects. For example, a

particular drug when used in treating cancer may work within acceptable limits

of overall risk, even though it produces a certain stain on the liver. But when

the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to

an otherwise healthy individual, are the mild feminizing effects of this

mediation worth the potentially serious health risks associated with its use?

This is the question the transgender patient should consider, and naturally, the

physician entrusted with the care of that individual is also considering.

> > > >

> > > > Looks like at the minimum we should decide if we want to go the

transgender route. I know at one point it was asked if spironolactone was used

for sex changes and the answer was " Not that I am aware of " if memory serves me

right. I can now say it is the medicine of choice dosed at 100 to 200 mg along

with a supplemental estrogen medicine according to atleast one support site!

> > > >

> > > > ....

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

I share Dr. Grim's wish for an acceptable BP for all, I believe in the J-Curve!

In addition I wish you to attain the best health possible which is why I decided

to start publishing what I was learning, knowing parts would be controversal for

some. I spent many hours researching and felt it would be a waste and selfish

to only use it for my treatment. I try to validate and post my sources so you

will know who my sources are. I have a pretty good record validating my sources

in my 27 year professionl career(they were used to make multi-million-dollar

decisions). I don't think I've done too badly in the 10+ months I've been

posting here! By all means, feel free to further validate those sources and

certainly post any adverse information you find.

I only ask that we try to keep this thread on subject and if you can use it,

great. If you find it worthless, ignore it. And if you have any input, please

post, I really appreciate other's views and experiences. Thanks.

....>

> > >

> > > > But all anti-androgens are far from a panacea. One should realize that

the bulk of these preparations used in transgender medicine are comprised of

drugs that produce an anti-androgenic effect incidental to their designed

purpose. The anti-androgens that some transgender patients are taking, are being

taken by many others for a variety of very different medical conditions that

include anti-hypertensive treatment (reducing high blood pressure), treating

prostactic cancer, prostatic enlargement, and fungal conditions, amongst others.

And as common sense would dictate, these drugs with their wide scope of uses may

also produce a wide variety of potentially serious side effects. For example, a

particular drug when used in treating cancer may work within acceptable limits

of overall risk, even though it produces a certain stain on the liver. But when

the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to

an otherwise healthy individual, are the mild feminizing effects of this

mediation worth the potentially serious health risks associated with its use?

This is the question the transgender patient should consider, and naturally, the

physician entrusted with the care of that individual is also considering.

> > > >

> > > > Looks like at the minimum we should decide if we want to go the

transgender route. I know at one point it was asked if spironolactone was used

for sex changes and the answer was " Not that I am aware of " if memory serves me

right. I can now say it is the medicine of choice dosed at 100 to 200 mg along

with a supplemental estrogen medicine according to atleast one support site!

> > > >

> > > > ....

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

sounds like good credentials. I have even heard of some of them. Would need to look at the report to see at what level of evidence they used to support these recommendations. CE Grim MD Okay, try this but I find it difficult to understand why you wouldn't take a little time to review is something is contrary IMHO to what you are advocating! If you don't have time to review my entire post, please pay particular to these paragraphs: 3.2, 4.1, 4.3,4.4 and 4.5 OK, since you don't trust what on-line support groups recommend, remind me what this group is, let's try this: All quotes are from: http://jcem.endojournals.org/content/94/9/3132.full which I found on Pubmed. Endocrine Treatment of Transsexual Persons:An Endocrine Society Clinical Practice Guideline Wylie C. Hembree, Peggy Cohen-Kettenis, Henriette A. Delemarre-van de Waal, Louis J. Gooren, Walter J. Meyer III, Norman P. Spack, Vin Tangpricha and Victor M. Montori1 - Author Affiliations Columbia University and New York Presbyterian Hospital (W.C.H.), New York, New York 10032; VU Medical Center (P.C-K., H.A.D.-v.d.W.), 1007 MB Amsterdam, The Netherlands; Leiden University Medical Center (H.A.D.-v.d.W.), 2300 RC Leiden, The Netherlands; Andro-consult (L.J.G.) ChaingMai 50220, Thailand; University of Texas Medical Branch (W.J.M.), Galveston, Texas 77555; Harvard Medical School (N.P.S.), Boston, Massachusetts 02115; Emory University School of Medicine (V.T.), Atlanta, Georgia 30322; and Mayo Clinic (V.M.M.), Rochester, Minnesota 55905 3.0 Hormonal therapy for transsexual adults 3.1 We recommend that treating endocrinologists confirm the diagnostic criteria of GID or transsexualism and the eligibility and readiness criteria for the endocrine phase of gender transition. (1 ¨'¨'¨'¡ð) 3.2 We recommend that medical conditions that can be exacerbated by hormone depletion and cross-sex hormone treatment be evaluated and addressed prior to initiation of treatment (see Table 11 & #8659;: Medical conditions that can be exacerbated by cross-sex hormone therapy). (1 ¨'¨'¨'¡ð) 3.3 We suggest that cross-sex hormone levels be maintained in the normal physiological range for the desired gender. (2 ¨'¨'¡ð¡ð) 3.4 We suggest that endocrinologists review the onset and time course of physical changes induced by cross-sex hormone treatment. (2 ¨'¨'¡ð¡ð) 4.0 Adverse outcome prevention and long-term care 4.1 We suggest regular clinical and laboratory monitoring every 3 months during the first year and then once or twice yearly. (2 ¨'¨'¡ð¡ð) 4.2 We suggest monitoring prolactin levels in male-to-female (MTF) transsexual persons treated with estrogens. (2 ¨'¨'¡ð¡ð) 4.3 We suggest that transsexual persons treated with hormones be evaluated for cardiovascular risk factors. (2 ¨'¨'¡ð¡ð) 4.4 We suggest that bone mineral density (BMD) measurements be obtained if risk factors for osteoporosis exist, specifically in those who stop hormone therapy after gonadectomy. (2 ¨'¨'¨'¡ð) 4.5 We suggest that MTF transsexual persons who have no known increased risk of breast cancer follow breast screening guidelines recommended for biological women. (2 ¨'¨'¡ð¡ð) 4.6 We suggest that MTF transsexual persons treated with estrogens follow screening guidelines for prostatic disease and prostate cancer recommended for biological men. (2 ¨'¡ð¡ð¡ð) 4.7 We suggest that female-to-male (FTM) transsexual persons evaluate the risks and benefits of including total hysterectomy and oophorectomy as part of sex reassignment surgery. (2 ¨'¡ð¡ð¡ð) Some of this doesn¡¯t apply but I didn¡¯t want to explain gaps! With these recommendations when Spironolactone is considered one of the primary medicines for this purpose, wouldn¡¯t it make sense whenever one is using the drug for whatever purpose? I suspect side effects are not unique to only that disease! .... > > > > > > > But all anti-androgens are far from a panacea. One should realize that the bulk of these preparations used in transgender medicine are comprised of drugs that produce an anti-androgenic effect incidental to their designed purpose. The anti-androgens that some transgender patients are taking, are being taken by many others for a variety of very different medical conditions that include anti-hypertensive treatment (reducing high blood pressure), treating prostactic cancer, prostatic enlargement, and fungal conditions, amongst others. And as common sense would dictate, these drugs with their wide scope of uses may also produce a wide variety of potentially serious side effects. For example, a particular drug when used in treating cancer may work within acceptable limits of overall risk, even though it produces a certain stain on the liver. But when the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to an otherwise healthy individual, are the mild feminizing effects of this mediation worth the potentially serious health risks associated with its use? This is the question the transgender patient should consider, and naturally, the physician entrusted with the care of that individual is also considering. > > > > > > > > Looks like at the minimum we should decide if we want to go the transgender route. I know at one point it was asked if spironolactone was used for sex changes and the answer was "Not that I am aware of" if memory serves me right. I can now say it is the medicine of choice dosed at 100 to 200 mg along with a supplemental estrogen medicine according to atleast one support site! > > > > > > > > .... > > > > > > > > > > > > > > > >

[Guest guest]

I would say refer to a transgender specialist if giving spiro to such a patient. And i assume these apply to those getting other hormone Rx besides spiro.CE Grim MD Does this make it easier for you (I was afraid you would require the background information). Maybe the ASH group would consider something like this for treating people w/Spironolactone. It probably applies to more than PA and HTN! (Obviously some of the numbers need to change if one is an unwilling participant of a gender change! TABLE 15. Monitoring of MTF transsexual persons on cross-hormone therapy 1. Evaluate patient every 2–3 months in the first year and then 1–2 times per year afterward to monitor for appropriate signs of feminization and for development of adverse reactions. 2. Measure serum testosterone and estradiol every 3 months. & #8195; & #8195; & #8195; & #8195;a. Serum testosterone levels should be <55 ng/dl. & #8195; & #8195; & #8195; & #8195;b. Serum estradiol should not exceed the peak physiological range for young healthy females, with ideal levels <200 pg/ml. & #8195; & #8195; & #8195; & #8195;c. Doses of estrogen should be adjusted according to the serum levels of estradiol. 3. For individuals on spironolactone, serum electrolytes (particularly potassium) should be monitored every 2–3 months initially in the first year. 4. Routine cancer screening is recommended in nontranssexual individuals (breasts, colon, prostate). 5. Consider BMD testing at baseline if risk factors for osteoporotic fracture are present (e.g. previous fracture, family history, glucocorticoid use, prolonged hypogonadism). In individuals at low risk, screening for osteoporosis should be conducted at age 60 and in those who are not compliant with hormone therapy. This Article Published online before print June 9, 2009, doi: 10.1210/jc.2009-0345 The Journal of Clinical Endocrinology & Metabolism September 1, 2009 vol. 94 no. 9 3132-3154 AbstractFree Full TextFree Full Text (PDF) > > > > > > > But all anti-androgens are far from a panacea. One should realize that the bulk of these preparations used in transgender medicine are comprised of drugs that produce an anti-androgenic effect incidental to their designed purpose. The anti-androgens that some transgender patients are taking, are being taken by many others for a variety of very different medical conditions that include anti-hypertensive treatment (reducing high blood pressure), treating prostactic cancer, prostatic enlargement, and fungal conditions, amongst others. And as common sense would dictate, these drugs with their wide scope of uses may also produce a wide variety of potentially serious side effects. For example, a particular drug when used in treating cancer may work within acceptable limits of overall risk, even though it produces a certain stain on the liver. But when the same drug is used to add a mild anti-androgenic (de-masculinizing) effect to an otherwise healthy individual, are the mild feminizing effects of this mediation worth the potentially serious health risks associated with its use? This is the question the transgender patient should consider, and naturally, the physician entrusted with the care of that individual is also considering. > > > > > > > > Looks like at the minimum we should decide if we want to go the transgender route. I know at one point it was asked if spironolactone was used for sex changes and the answer was "Not that I am aware of" if memory serves me right. I can now say it is the medicine of choice dosed at 100 to 200 mg along with a supplemental estrogen medicine according to atleast one support site! > > > > > > > > .... > > > > > > > > > > > > > > > >

[Guest guest]

I ask the pt- any breast pain problems. If yes then can explore more and do exam. Will the Document and push DASH. If this enables reduction of spiro so much boobies go away then continue If not then do eplerenone. stop Spiro and used to use other Rx till eplerenone. Now use epler and DASHING more. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

You are missing my point. To the best of my knowledge every person who you have recommended "Spiro and DASH" to are NOT knowingly seeking a sex change so a Transgender Specialist is not appropriate! I say it needs to be looked at by every speciality using it and the proper proactive testing established. (I used the transgender site because they had the most complete "cause and effect" I have seen.) It's important that we know what side effects to watch and when to call a halt to the lab test (Us).

.....

> > > > >

> > > > > > But all anti-androgens are far from a panacea. One should

> > realize that the bulk of these preparations used in transgender

> > medicine are comprised of drugs that produce an anti-androgenic

> > effect incidental to their designed purpose. The anti-androgens that

> > some transgender patients are taking, are being taken by many others

> > for a variety of very different medical conditions that include anti-

> > hypertensive treatment (reducing high blood pressure), treating

> > prostactic cancer, prostatic enlargement, and fungal conditions,

> > amongst others. And as common sense would dictate, these drugs with

> > their wide scope of uses may also produce a wide variety of

> > potentially serious side effects. For example, a particular drug

> > when used in treating cancer may work within acceptable limits of

> > overall risk, even though it produces a certain stain on the liver.

> > But when the same drug is used to add a mild anti-androgenic (de-

> > masculinizing) effect to an otherwise healthy individual, are the

> > mild feminizing effects of this mediation worth the potentially

> > serious health risks associated with its use? This is the question

> > the transgender patient should consider, and naturally, the

> > physician entrusted with the care of that individual is also

> > considering.

> > > > > >

> > > > > > Looks like at the minimum we should decide if we want to go

> > the transgender route. I know at one point it was asked if

> > spironolactone was used for sex changes and the answer was "Not that

> > I am aware of" if memory serves me right. I can now say it is the

> > medicine of choice dosed at 100 to 200 mg along with a supplemental

> > estrogen medicine according to atleast one support site!

> > > > > >

> > > > > > ....

> > > > > >

> > > > > >

> > > > >

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

I think the operative word is " pain " as I never experienced any. And since I

have been on 25mg bid of spiro it wasn't considered a massive amount and didn't

raise any red flags.

> > > > > > >

> > > > > > > > But all anti-androgens are far from a panacea. One should

> > > > realize that the bulk of these preparations used in transgender

> > > > medicine are comprised of drugs that produce an anti-androgenic

> > > > effect incidental to their designed purpose. The anti-androgens that

> > > > some transgender patients are taking, are being taken by many others

> > > > for a variety of very different medical conditions that include anti-

> > > > hypertensive treatment (reducing high blood pressure), treating

> > > > prostactic cancer, prostatic enlargement, and fungal conditions,

> > > > amongst others. And as common sense would dictate, these drugs with

> > > > their wide scope of uses may also produce a wide variety of

> > > > potentially serious side effects. For example, a particular drug

> > > > when used in treating cancer may work within acceptable limits of

> > > > overall risk, even though it produces a certain stain on the liver.

> > > > But when the same drug is used to add a mild anti-androgenic (de-

> > > > masculinizing) effect to an otherwise healthy individual, are the

> > > > mild feminizing effects of this mediation worth the potentially

> > > > serious health risks associated with its use? This is the question

> > > > the transgender patient should consider, and naturally, the

> > > > physician entrusted with the care of that individual is also

> > > > considering.

> > > > > > > >

> > > > > > > > Looks like at the minimum we should decide if we want to go

> > > > the transgender route. I know at one point it was asked if

> > > > spironolactone was used for sex changes and the answer was " Not that

> > > > I am aware of " if memory serves me right. I can now say it is the

> > > > medicine of choice dosed at 100 to 200 mg along with a supplemental

> > > > estrogen medicine according to atleast one support site!

> > > > > > > >

> > > > > > > > ....

> > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > > >

> > > > >

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

my side effects-mostly the gyneco as far as I could tell (felt like I had rocks

under my nipples) went away when I got more serious about dashing and went to

12.5 of spiro.

Now, I have been feeling a little sick of late and BP less controlled so I went

12.5 twice a day a couple of times and the SE's start a little.

in my case the spiro wrked so well, as did DASH, that I never asked to change to

epe, but insurance doesn't cover it anyway. But IF the SE would have stayed I

would have changed. Don't like the tune in tokyo nipples....on me that is

>I think the operative word is " pain " as I never experienced any. And since I

have been on 25mg bid of spiro it wasn't considered a massive amount and didn't

raise any red flags.

>

>

>> > > > > > >

>> > > > > > > > But all anti-androgens are far from a panacea. One should

>> > > > realize that the bulk of these preparations used in transgender

>> > > > medicine are comprised of drugs that produce an anti-androgenic

>> > > > effect incidental to their designed purpose. The anti-androgens that

>> > > > some transgender patients are taking, are being taken by many others

>> > > > for a variety of very different medical conditions that include anti-

>> > > > hypertensive treatment (reducing high blood pressure), treating

>> > > > prostactic cancer, prostatic enlargement, and fungal conditions,

>> > > > amongst others. And as common sense would dictate, these drugs with

>> > > > their wide scope of uses may also produce a wide variety of

>> > > > potentially serious side effects. For example, a particular drug

>> > > > when used in treating cancer may work within acceptable limits of

>> > > > overall risk, even though it produces a certain stain on the liver.

>> > > > But when the same drug is used to add a mild anti-androgenic (de-

>> > > > masculinizing) effect to an otherwise healthy individual, are the

>> > > > mild feminizing effects of this mediation worth the potentially

>> > > > serious health risks associated with its use? This is the question

>> > > > the transgender patient should consider, and naturally, the

>> > > > physician entrusted with the care of that individual is also

>> > > > considering.

>> > > > > > > >

>> > > > > > > > Looks like at the minimum we should decide if we want to go

>> > > > the transgender route. I know at one point it was asked if

>> > > > spironolactone was used for sex changes and the answer was " Not that

>> > > > I am aware of " if memory serves me right. I can now say it is the

>> > > > medicine of choice dosed at 100 to 200 mg along with a supplemental

>> > > > estrogen medicine according to atleast one support site!

>> > > > > > > >

>> > > > > > > > ....

>> > > > > > > >

>> > > > > > > >

>> > > > > > >

>> > > > > >

>> > > > > >

>> > > > >

>> > > >

>> > > >

>> > >

>> >

>> >

>>

>

>

[Guest guest]

Point Taken. But the side effects on with the other hormones are likely not the same as with sprio alone. But will keep this in mind as a future side for folks to look at if needed.CE Grim MD You are missing my point. To the best of my knowledge every person who you have recommended "Spiro and DASH" to are NOT knowingly seeking a sex change so a Transgender Specialist is not appropriate! I say it needs to be looked at by every speciality using it and the proper proactive testing established. (I used the transgender site because they had the most complete "cause and effect" I have seen.) It's important that we know what side effects to watch and when to call a halt to the lab test (Us). .... > > > > > > > > > > > But all anti-androgens are far from a panacea. One should > > realize that the bulk of these preparations used in transgender > > medicine are comprised of drugs that produce an anti-androgenic > > effect incidental to their designed purpose. The anti-androgens that > > some transgender patients are taking, are being taken by many others > > for a variety of very different medical conditions that include anti- > > hypertensive treatment (reducing high blood pressure), treating > > prostactic cancer, prostatic enlargement, and fungal conditions, > > amongst others. And as common sense would dictate, these drugs with > > their wide scope of uses may also produce a wide variety of > > potentially serious side effects. For example, a particular drug > > when used in treating cancer may work within acceptable limits of > > overall risk, even though it produces a certain stain on the liver. > > But when the same drug is used to add a mild anti-androgenic (de- > > masculinizing) effect to an otherwise healthy individual, are the > > mild feminizing effects of this mediation worth the potentially > > serious health risks associated with its use? This is the question > > the transgender patient should consider, and naturally, the > > physician entrusted with the care of that individual is also > > considering. > > > > > > > > > > > > Looks like at the minimum we should decide if we want to go > > the transgender route. I know at one point it was asked if > > spironolactone was used for sex changes and the answer was "Not that > > I am aware of" if memory serves me right. I can now say it is the > > medicine of choice dosed at 100 to 200 mg along with a supplemental > > estrogen medicine according to atleast one support site! > > > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > >

[Guest guest]

You are right that is not a lot of spiro. What exactly was the time of onset of the enlargement? Other meds/problems can cause this as well.CE Grim MD

[Guest guest]

I believe we are in agreement that Spiro, as an Antiandrogens, or androgen

antagonists will bind to testosterone and reduce the amount in one's system.

Everything I've read says this allows for more circulating estrogen which has no

apparent effect on most men, the operative word may be apparent! I feel we

should be looking to see what may be happening that may not be readily visible.

If you have a basement that is prone to flooding but never open the door to look

it doesn't mean it isn't happening! Don't wait until the furnace doesn't start

to figure out you have a problem!

To bring this back into focus I looked at WEBMD (

http://men.webmd.com/features/how-low-testosterone-affects-your-health?page=2 )

and found this: " The Hidden Effects of Low Testosterone

" Guys, can you try to think of something other than sex for just a moment?

Testosterone is more than just fuel for a sex machine. Low testosterone levels

can also cause:

Decreases in bone density, which can lead to osteoporosis.

Diminishing ability to concentrate, as well as irritability and depression.

Increases in body fat,particularly in the midsection, where the buildup puts

them at heightened risk for type 2 diabetes, heart disease, and certain

cancers. "

I recommend you don't wait until you " break a leg " to check out how it is

affecting you! , I'm not licensed to practice medicine but you might read

the second suggestion again - Is something else going on beside your low K

issues? (I'm not sure we have to even grow boobs to be suffering some effects!)

….

> >> > > > > > >

> >> > > > > > > > But all anti-androgens are far from a panacea. One should

> >> > > > realize that the bulk of these preparations used in transgender

> >> > > > medicine are comprised of drugs that produce an anti-androgenic

> >> > > > effect incidental to their designed purpose. The anti-androgens that

> >> > > > some transgender patients are taking, are being taken by many others

> >> > > > for a variety of very different medical conditions that include anti-

> >> > > > hypertensive treatment (reducing high blood pressure), treating

> >> > > > prostactic cancer, prostatic enlargement, and fungal conditions,

> >> > > > amongst others. And as common sense would dictate, these drugs with

> >> > > > their wide scope of uses may also produce a wide variety of

> >> > > > potentially serious side effects. For example, a particular drug

> >> > > > when used in treating cancer may work within acceptable limits of

> >> > > > overall risk, even though it produces a certain stain on the liver.

> >> > > > But when the same drug is used to add a mild anti-androgenic (de-

> >> > > > masculinizing) effect to an otherwise healthy individual, are the

> >> > > > mild feminizing effects of this mediation worth the potentially

> >> > > > serious health risks associated with its use? This is the question

> >> > > > the transgender patient should consider, and naturally, the

> >> > > > physician entrusted with the care of that individual is also

> >> > > > considering.

> >> > > > > > > >

> >> > > > > > > > Looks like at the minimum we should decide if we want to go

> >> > > > the transgender route. I know at one point it was asked if

> >> > > > spironolactone was used for sex changes and the answer was " Not that

> >> > > > I am aware of " if memory serves me right. I can now say it is the

> >> > > > medicine of choice dosed at 100 to 200 mg along with a supplemental

> >> > > > estrogen medicine according to atleast one support site!

> >> > > > > > > >

> >> > > > > > > > ....

> >> > > > > > > >

> >> > > > > > > >

> >> > > > > > >

> >> > > > > >

> >> > > > > >

> >> > > > >

> >> > > >

> >> > > >

> >> > >

> >> >

> >> >

> >>

> >

> >

>

[Guest guest]

I will have to look that up when I get back from Boston. I'm thinking it was

soon after I started because my PCP had a panic attack when I suggested

switching because my BP was so good. It may have when they raised it to 25mg

bid after bout 6 months but I don't think so.

.....

>

> You are right that is not a lot of spiro. What exactly was the time

> of onset of the enlargement? Other meds/problems can cause this as

> well.

>

> CE Grim MD

>

[Guest guest]

I'm back on this subject. I was going to ask Endo yesterday but realized it

would be fruitless since she knew very little about PA and neither she or her

department head knew much about Spiro.

Tonight an ad came on TV (isitlowT.com) that got me thinking. I researched it a

little and here is what I found:

Hypogonadism

Hypogonadism is the condition in which the production of sex hormones and germ

cells (sperm and eggs) is inadequate.

If hypogonadism occurs after puberty, infertility and sexual dysfunction result.

The demographics of hypogonadism vary depending on the cause. XYY syndrome has

an incidence of one in 1,000 newborn males. However, since many males with XYY

syndrome look like other males without XYY syndrome, they may never be

identified.

A number of adverse events can damage the gonads and result in decreased hormone

levels. The childhood disease mumps, if acquired after puberty, can infect and

destroy the testicles—a disease called viral orchitis. Ionizing radiation and

chemotherapy, trauma, several drugs (spironolactone, a diuretic, and

ketoconazole, an antifungal agent), alcohol, marijuana, heroin, methadone, and

environmental toxins can all damage testicles and decrease their hormone

production. Severe diseases in the liver or kidneys, certain infections, sickle

cell anemia, and some cancers also affect gonads. To treat some male cancers, it

is necessary to remove the testicles, thereby preventing the androgens from

stimulating cancer growth. This procedure, called castration or orchiectomy,

removes androgen stimulation from the whole body.

Read more: http://www.answers.com/topic/hypogonadism#ixzz1gTI2k6RM

Source: http://www.answers.com/topic/hypogonadism

I remind you that I always reported right testis pain when I had PA SXs. Could

my testosterone have already been low before starting Spiro? I see drugs that

may affect are Spironolactone and METHADONE! I was on a 5-year regiment of

methadone prior to starting Spironlactone! Could I have a XXY syndrome

(Klinefelter's syndrome)?

BTW, I went back and looked at the article you posted and found all this, it is

just more technical so harder for a layman to pull it all together.

I think this should all be taken into consideration when RXing Spiro. Ideally

simple tests could be run and if positive it would warrent going directly to

Eplerenone. (At the minimum it should cause treating doctor to be on high

alert!) Haven't decided to share this with 3 Nepers and 2 Endos or keep it a

secret between my PCP and me! (I'm no good at keeping secrets!)

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

>

> > I'm quite convinced that Inspra (prior spiro) is binding my progesterone

reception. Progesterone is simply not working for me like it's supposed to.

> >

> >

> >

> > Val

> >

> >

> >

> > From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of

> >

> >

> > I believe we are in agreement that Spiro, as an Antiandrogens, or androgen

antagonists will bind to testosterone and reduce the amount in one's system.

Everything I've read says this allows for more circulating estrogen which has no

apparent effect on most men, the operative word may be apparent! I feel we

should be looking to see what may be happening that may not be readily visible.

> >

> >

> > .

> >

> >

> >

> >

> >

>

[Guest guest]

Not likely u have Kleinfelter's. If u have not need to read details on KFs and see what you fit. Google KleinF for images. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

I'm back on this subject. I was going to ask Endo yesterday but realized it would be fruitless since she knew very little about PA and neither she or her department head knew much about Spiro.

Tonight an ad came on TV (isitlowT.com) that got me thinking. I researched it a little and here is what I found:

Hypogonadism

Hypogonadism is the condition in which the production of sex hormones and germ cells (sperm and eggs) is inadequate.

If hypogonadism occurs after puberty, infertility and sexual dysfunction result. The demographics of hypogonadism vary depending on the cause. XYY syndrome has an incidence of one in 1,000 newborn males. However, since many males with XYY syndrome look like other males without XYY syndrome, they may never be identified.

A number of adverse events can damage the gonads and result in decreased hormone levels. The childhood disease mumps, if acquired after puberty, can infect and destroy the testicles—a disease called viral orchitis. Ionizing radiation and chemotherapy, trauma, several drugs (spironolactone, a diuretic, and ketoconazole, an antifungal agent), alcohol, marijuana, heroin, methadone, and environmental toxins can all damage testicles and decrease their hormone production. Severe diseases in the liver or kidneys, certain infections, sickle cell anemia, and some cancers also affect gonads. To treat some male cancers, it is necessary to remove the testicles, thereby preventing the androgens from stimulating cancer growth. This procedure, called castration or orchiectomy, removes androgen stimulation from the whole body.

Read more: http://www.answers.com/topic/hypogonadism#ixzz1gTI2k6RM

Source: http://www.answers.com/topic/hypogonadism

I remind you that I always reported right testis pain when I had PA SXs. Could my testosterone have already been low before starting Spiro? I see drugs that may affect are Spironolactone and METHADONE! I was on a 5-year regiment of methadone prior to starting Spironlactone! Could I have a XXY syndrome (Klinefelter's syndrome)?

BTW, I went back and looked at the article you posted and found all this, it is just more technical so harder for a layman to pull it all together.

I think this should all be taken into consideration when RXing Spiro. Ideally simple tests could be run and if positive it would warrent going directly to Eplerenone. (At the minimum it should cause treating doctor to be on high alert!) Haven't decided to share this with 3 Nepers and 2 Endos or keep it a secret between my PCP and me! (I'm no good at keeping secrets!)

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

>

> > I'm quite convinced that Inspra (prior spiro) is binding my progesterone reception. Progesterone is simply not working for me like it's supposed to.

> >

> >

> >

> > Val

> >

> >

> >

> > From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of

> >

> >

> > I believe we are in agreement that Spiro, as an Antiandrogens, or androgen antagonists will bind to testosterone and reduce the amount in one's system. Everything I've read says this allows for more circulating estrogen which has no apparent effect on most men, the operative word may be apparent! I feel we should be looking to see what may be happening that may not be readily visible.

> >

> >

> > .

> >

> >

> >

> >

> >

>

[Guest guest]

Not sure what you are suggesting I google. As I understand it there are

variations and XYY is the most common occuring in 1 in every 500 to 1000 males.

Many times it is unnoticed unless you do testing. How can you DX w/o doing

chromosomes testing?

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> > >

> > > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone

reception. Progesterone is simply not working for me like it's supposed to.

> > > >

> > > >

> > > >

> > > > Val

> > > >

> > > >

> > > >

> > > > From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of

> > > >

> > > >

> > > > I believe we are in agreement that Spiro, as an Antiandrogens, or

androgen antagonists will bind to testosterone and reduce the amount in one's

system. Everything I've read says this allows for more circulating estrogen

which has no apparent effect on most men, the operative word may be apparent! I

feel we should be looking to see what may be happening that may not be readily

visible.

> > > >

> > > >

> > > > .

> > > >

> > > >

> > > >

> > > >

> > > >

> > >

> >

> >

>

[Guest guest]

It is a possibility that the tumor can cause other parts of the gland to over or

under produce other steroids like androgenic steroids.

> >

> > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone

reception. Progesterone is simply not working for me like it's supposed to.

> > >

> > >

> > >

> > > Val

> > >

> > >

> > >

> > > From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of

> > >

> > >

> > > I believe we are in agreement that Spiro, as an Antiandrogens, or androgen

antagonists will bind to testosterone and reduce the amount in one's system.

Everything I've read says this allows for more circulating estrogen which has no

apparent effect on most men, the operative word may be apparent! I feel we

should be looking to see what may be happening that may not be readily visible.

> > >

> > >

> > > .

> > >

> > >

> > >

> > >

> > >

> >

>

[Guest guest]

Another possibility for low testosterone?

Low T & diabetes

Between 33% to 50% of men with diabetes may have Low T

If you're living with a chronic condition like diabetes, you know how

challenging it can be to cope with the short-term effects and the long-term

complications of your condition. Studies have shown that men who have diabetes

may be more likely to have hypogonadism, which can be caused by Low T. If you're

having symptoms of Low T, talk to your doctor and ask if you may need to have

your testosterone levels checked at your next regular visit.

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> >

> > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone

reception. Progesterone is simply not working for me like it's supposed to.

> > >

> > >

> > >

> > > Val

> > >

> > >

> > >

> > > From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of

> > >

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> > > I believe we are in agreement that Spiro, as an Antiandrogens, or androgen

antagonists will bind to testosterone and reduce the amount in one's system.

Everything I've read says this allows for more circulating estrogen which has no

apparent effect on most men, the operative word may be apparent! I feel we

should be looking to see what may be happening that may not be readily visible.

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[Guest guest]

Pain meds are often overlooked as a factor that decreases T in men too, but we are seeing it more and more as more and more are on long term opiates and more men are asking for something to "pep" it up.

I am glad at least the commercials are bringing attention to low T, cause as I always say:

MEN HAVE HORMONES TOO!

Subject: Re: Spironolactone Side Effects, Is It Right For You?To: hyperaldosteronism Date: Wednesday, December 14, 2011, 8:55 AM

Another possibility for low testosterone?Low T & diabetesBetween 33% to 50% of men with diabetes may have Low TIf you're living with a chronic condition like diabetes, you know how challenging it can be to cope with the short-term effects and the long-term complications of your condition. Studies have shown that men who have diabetes may be more likely to have hypogonadism, which can be caused by Low T. If you're having symptoms of Low T, talk to your doctor and ask if you may need to have your testosterone levels checked at your next regular visit. - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > > > > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone reception. Progesterone is simply not working for me like it's supposed to.> > > > > > > > > > > > Val> > > > > > > > > > > > From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of > > > > > > > > > I believe we are in agreement that Spiro, as an Antiandrogens, or androgen antagonists will bind to testosterone and reduce the amount in one's system. Everything I've read says this allows for more circulating estrogen which has no apparent effect on most men, the operative word may be apparent! I feel we should be looking to see what may be happening that may not be readily visible.> > > > > > > > > .> > > > > > > > > > > > > >

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