Spironolactone Side Effects, Is It Right For You?

December 14, 2011

And probably many of them don't admit it when they get it on the street corner!

(I had a " drug contract " at the VA so I was subject to random blood tests.)

You'll be happy to know I cut the Endo some slack when she got to that point!

She asked if the duloxetine (Cymblta) was helping. I explained that I didn't

know since I had not tried to stop it so I didn't know how to tell. She then

proceeded to ask me two more time! I did explain that my Psychrist had recently

given me permission to TRY stepping it down. (emphsis hers!) I didn't explin

that I had stopped Methadone, Oxycodone and Mirtazapine (all long term

regiments) in the last 6-months. I also didn't explain it was also used for

T2DM Neuropathy. Do I get an ATTABOY for that?

> > >

> > > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone

reception. Progesterone is simply not working for me like it's supposed to.

> > > >

> > > > Val

> > > >

> > > > From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of

> > > >

> > > > I believe we are in agreement that Spiro, as an Antiandrogens, or

androgen antagonists will bind to testosterone and reduce the amount in one's

system. Everything I've read says this allows for more circulating estrogen

which has no apparent effect on most men, the operative word may be apparent! I

feel we should be looking to see what may be happening that may not be readily

visible.

> > > >

> > > > .

> > > >

> > >

> >

>

December 14, 2011

Good point. Honesty is not usually a strong trait of street users.

Subject: Re: Spironolactone Side Effects, Is It Right For You?To: hyperaldosteronism Date: Wednesday, December 14, 2011, 10:50 AM

And probably many of them don't admit it when they get it on the street corner! (I had a "drug contract" at the VA so I was subject to random blood tests.)You'll be happy to know I cut the Endo some slack when she got to that point! She asked if the duloxetine (Cymblta) was helping. I explained that I didn't know since I had not tried to stop it so I didn't know how to tell. She then proceeded to ask me two more time! I did explain that my Psychrist had recently given me permission to TRY stepping it down. (emphsis hers!) I didn't explin that I had stopped Methadone, Oxycodone and Mirtazapine (all long term regiments) in the last 6-months. I also didn't explain it was also used for T2DM Neuropathy. Do I get an ATTABOY for that?> > > > > > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone reception. Progesterone is simply not working for me like it's supposed to.> > > > > > > > > > > > > > > > Val> > > > > > > > > > > > > > > > From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of > > > > > > > > > > > > I

believe we are in agreement that Spiro, as an Antiandrogens, or androgen antagonists will bind to testosterone and reduce the amount in one's system. Everything I've read says this allows for more circulating estrogen which has no apparent effect on most men, the operative word may be apparent! I feel we should be looking to see what may be happening that may not be readily visible.> > > > > > > > > > > > .> > > > > > > > > > > > > > > > > > > >> > >> >>

December 16, 2011

I came across this comparison this morning and thought others might be

interested.

Source:

http://apps.elsevier.es/watermark/ctl_servlet?_f=10 & pident_articulo=13154104 & pid\

ent_usuario=0 & pcontactid= & pident_revista=255 & ty=100 & accion=L & origen=elsevier & web\

=www.revespcardiol.org & lan=en & fichero=255v63n07a13154104pdf001.pdf

Rev Esp Cardiol. 2010 Jul;63(7):779-87.

Differential actions of eplerenone and spironolactone on the protective effect

of testosterone against cardiomyocyte apoptosis in vitro.

[Article in English, Spanish]

Sánchez-Más J, Turpín MC, Lax A, Ruipérez JA, Valdés Chávarri M, Pascual-Figal

DA.

Source

Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Hospital

Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de

Murcia, El Palmar, Murcia, Spain.

I wish they would write these so us " Normal Dummies " could understand it! I had

to look this up so I'll save you the trouble:

Apoptosis

For every cell, there is a time to live and a time to die.

There are two ways in which cells die:

They are killed by injurious agents.

They are induced to commit suicide.

CONCLUSIONS:

Testosterone appears to have a protective effect against cardiomyocyte apoptosis

which is antagonized by spironolactone but not by eplerenone. These effects

await confirmation in in vivo models, but their presence could have clinical and

therapeutic implications.

IMHO it looks like we are part of that confirmation process! Have you fixed

your BP and destroyed your heart today? (I guess another way to look at it is,

Is your heart worth a couple hundred dollars a month?) Ask your doctor, Ask

your insurance carrier, Ask your government!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> > > >

> > > > > I'm quite convinced that Inspra (prior spiro) is binding my

progesterone reception. Progesterone is simply not working for me like it's

supposed to.

> > > > >

> > > > > Val

> > > > >

> > > > > From: hyperaldosteronism

[mailto:hyperaldosteronism ] On Behalf Of

> > > > >

> > > > > I believe we are in agreement that Spiro, as an Antiandrogens, or

androgen antagonists will bind to testosterone and reduce the amount in one's

system. Everything I've read says this allows for more circulating estrogen

which has no apparent effect on most men, the operative word may be apparent! I

feel we should be looking to see what may be happening that may not be readily

visible.

> > > > >

> > > > > .

> > > > >

> > > >

> > >

> >

>

December 16, 2011

Thanks. Nice basic science study in cells. Suggests epler would be better than spiro over long haul but proper studies need to be done. Clearly better if you have CHF.CE Grim MD I came across this comparison this morning and thought others might be interested. Source: http://apps.elsevier.es/watermark/ctl_servlet?_f=10 & pident_articulo=13154104 & pident_usuario=0 & pcontactid= & pident_revista=255 & ty=100 & accion=L & origen=elsevier & web=www.revespcardiol.org & lan=en & fichero=255v63n07a13154104pdf001.pdf Rev Esp Cardiol. 2010 Jul;63(7):779-87. Differential actions of eplerenone and spironolactone on the protective effect of testosterone against cardiomyocyte apoptosis in vitro. [Article in English, Spanish] Sánchez-Más J, Turpín MC, Lax A, Ruipérez JA, Valdés Chávarri M, Pascual-Figal DA. Source Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Facultad de Medicina, Universidad de Murcia, El Palmar, Murcia, Spain. I wish they would write these so us "Normal Dummies" could understand it! I had to look this up so I'll save you the trouble: Apoptosis For every cell, there is a time to live and a time to die. There are two ways in which cells die: They are killed by injurious agents. They are induced to commit suicide. CONCLUSIONS: Testosterone appears to have a protective effect against cardiomyocyte apoptosis which is antagonized by spironolactone but not by eplerenone. These effects await confirmation in in vivo models, but their presence could have clinical and therapeutic implications. IMHO it looks like we are part of that confirmation process! Have you fixed your BP and destroyed your heart today? (I guess another way to look at it is, Is your heart worth a couple hundred dollars a month?) Ask your doctor, Ask your insurance carrier, Ask your government! - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60 Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD. Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > > > > > > > > > I'm quite convinced that Inspra (prior spiro) is binding my progesterone reception. Progesterone is simply not working for me like it's supposed to. > > > > > > > > > > > > > > > > > > > > Val > > > > > > > > > > > > > > > > > > > > From: hyperaldosteronism [mailto:hyperaldosteronism ] On Behalf Of > > > > > > > > > > > > > > > I believe we are in agreement that Spiro, as an Antiandrogens, or androgen antagonists will bind to testosterone and reduce the amount in one's system. Everything I've read says this allows for more circulating estrogen which has no apparent effect on most men, the operative word may be apparent! I feel we should be looking to see what may be happening that may not be readily visible. > > > > > > > > > > > > > > > . > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > >

December 16, 2011

I'm unsure what the long term studies that need to be done and when they will be

started. Is there enough experience that elper works in PA? Is it less likely

to cause problems or does that need to be tested? If money was not an issue,

which drug would you suggest starting with?

.....

> > > > > >

> > > > > > > I'm quite convinced that Inspra (prior spiro) is binding

> > my progesterone reception. Progesterone is simply not working for me

> > like it's supposed to.

> > > > > > >

> > > > > > > Val

> > > > > > >

> > > > > > > From: hyperaldosteronism

[mailto:hyperaldosteronism

> > ] On Behalf Of

> > > > > > >

> > > > > > > I believe we are in agreement that Spiro, as an

> > Antiandrogens, or androgen antagonists will bind to testosterone and

> > reduce the amount in one's system. Everything I've read says this

> > allows for more circulating estrogen which has no apparent effect on

> > most men, the operative word may be apparent! I feel we should be

> > looking to see what may be happening that may not be readily visible.

> > > > > > >

> > > > > > > .

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

December 16, 2011

You would have to know if testosterone or related hormones were normal before

starting sprio.

> > > > > > > > >

> > > > > > > > > > I'm quite convinced that Inspra (prior spiro) is binding

> > > > > my progesterone reception. Progesterone is simply not working for me

> > > > > like it's supposed to.

> > > > > > > > > >

> > > > > > > > > > Val

> > > > > > > > > >

> > > > > > > > > > From: hyperaldosteronism

[mailto:hyperaldosteronism

> > > > > ] On Behalf Of

> > > > > > > > > >

> > > > > > > > > > I believe we are in agreement that Spiro, as an

> > > > > Antiandrogens, or androgen antagonists will bind to testosterone and

> > > > > reduce the amount in one's system. Everything I've read says this

> > > > > allows for more circulating estrogen which has no apparent effect on

> > > > > most men, the operative word may be apparent! I feel we should be

> > > > > looking to see what may be happening that may not be readily visible.

> > > > > > > > > >

> > > > > > > > > > .

> > > > > > > > > >

> > > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

December 16, 2011

That would be the design. Only need funding. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

I know, I know but how does that tell us if eplere works as well as spiro? Also if you keep the "easy to treat" cases on Spiro aren't you biasing the result? I say reverse it and switch to spiro if eplere and documented DASH doesn't work! How many PTNs need to switch after say 4 or more years?

I'm also wondering how many that are affected by lack of testosterone develop CHF and is it identified as such or is it just charged off as previous HTN. Might be an interesting project! How about a random study treating half w/spiro and the other half w/elpere?

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > > > > > > >

> > > > > > > > > I'm quite convinced that Inspra (prior spiro) is binding

> > > > my progesterone reception. Progesterone is simply not working for me

> > > > like it's supposed to.

> > > > > > > > >

> > > > > > > > > Val

> > > > > > > > >

> > > > > > > > > From: hyperaldosteronism [mailto:hyperaldosteronism

> > > > ] On Behalf Of

> > > > > > > > >

> > > > > > > > > I believe we are in agreement that Spiro, as an

> > > > Antiandrogens, or androgen antagonists will bind to testosterone and

> > > > reduce the amount in one's system. Everything I've read says this

> > > > allows for more circulating estrogen which has no apparent effect on

> > > > most men, the operative word may be apparent! I feel we should be

> > > > looking to see what may be happening that may not be readily visible.

> > > > > > > > >

> > > > > > > > > .

> > > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

December 16, 2011

Not necessarily but it might be good to check to see if you can stand Spiro.

> > > > > > > > > >

> > > > > > > > > > > I'm quite convinced that Inspra (prior spiro) is binding

> > > > > > my progesterone reception. Progesterone is simply not working for me

> > > > > > like it's supposed to.

> > > > > > > > > > >

> > > > > > > > > > > Val

> > > > > > > > > > >

> > > > > > > > > > > From: hyperaldosteronism

[mailto:hyperaldosteronism

> > > > > > ] On Behalf Of

> > > > > > > > > > >

> > > > > > > > > > > I believe we are in agreement that Spiro, as an

> > > > > > Antiandrogens, or androgen antagonists will bind to testosterone and

> > > > > > reduce the amount in one's system. Everything I've read says this

> > > > > > allows for more circulating estrogen which has no apparent effect on

> > > > > > most men, the operative word may be apparent! I feel we should be

> > > > > > looking to see what may be happening that may not be readily

visible.

> > > > > > > > > > >

> > > > > > > > > > > .

> > > > > > > > > > >

> > > > > > > > > >

> > > > > > > > >

> > > > > > > >

> > > > > > >

> > > > > >

> > > > >

> > > >

> > >

> >

>

January 6, 2012

During my research re: Spironolactone I specifically focused on the Male gender.

This should give you ladies a good start if you want to understand what it my be

doing to, I mean for, you!

Source:

http://www.uptodate.com/contents/androgen-production-and-therapy-in-women?source\

=see_link

INTRODUCTION

All women produce some androgens, which may contribute to maintaining normal

ovarian function, bone metabolism, cognition, and sexual behavior. This topic

will review androgen production in pre- and postmenopausal women and the effects

of androgen therapy in postmenopausal women. Female sexual dysfunction,

including hypoactive sexual desire disorder, is discussed elsewhere. (See

" Sexual dysfunction in women: Epidemiology, risk factors, and evaluation " and

" Sexual dysfunction in women: Management " .)

up-to-date.com is somewhat limited with the free patient information but

provides all the reference material and if you click on it you are taken to the

actual trial/study. Check it out!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with DASH. 2-Day ave w/o meds = BP 133/77 HR 61 BS 132. D/C

Spironolactone 12/20/2011 due to adverse SX.

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD

and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg aspirin and

Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.

Sign In

Spironolactone Side Effects, Is It Right For You?

Recommended Posts

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Guest guest

Link to comment

Share on other sites

Join the conversation

Activity