jackie

[Guest guest]

Jackie,

Thank you so much! I don't know anybody here yet. How are you doing?

Love,

Reply-To: LBDcaregivers

Date: Thu, 12 Sep 2002 10:49:19 -0400

To: <LBDcaregivers >

Subject: Re: LBD/atypical Parkinsins/broken arm

Hi ,

I am so sorry for what your father and family are going through. You are in

my prayers.

May God bless you!

Jackie

Re: LBD/atypical Parkinsins/broken arm

Hello!

I am so happy to have found this email list. I wish I had searched for it

before, but I wasn't aware that my Dad had this form of dementia until

recently. We knew he had dementia, and that it was progressing, but did not

have enough info about the LBD. I just purchased a laptop so that I can

log

on from Mom and Pop's house. I'm there every day now. I have been reading

your posts with great interest. It has been a comfort.

This list would have helped us so much in the earlier days when we were so

completely baffled by his dementia. The ups and downs were a true emotional

roller coaster ride. We would have coped better had we known more about

this

disease. Poor mom would get so hopeful every time he seemed to rally.

Until

very recently, she never lost hope that he'd get better somehow -- a cure,

a

miracle... anything!

He has suffered from atypical Parkinsons since his late 50's. He is 67 now,

and he has now reached the point where he is bedridden. We are caring for

him at home. His verbal abilities are almost nil now. Now we're trying to

move him around to prevent pneumonia. He cannot move at all now.

The latest extreme decline came after he got out of bed by himself, fell,

and broke his arm quite badly. The dementia spiraled out of control after

that incident. Now he has pain to deal with! I spoke with his orthopedic

surgeon yesterday. It's a bad break which normally requires surgery so that

the patient can regain function. Well, he has no function anyway and the

surgery would be so risky. Additionally, the pain would be worse for quite

some time. So, we're going to manage let it keep healing, manage the pain,

and keep him as comfortable as possible.

I'm so glad to have found you!

Love,

[Guest guest]

Hi !

Thanks for asking but you might not want to know. My mother is 81 years old and

we don't really have a diagnosis yet. Her neurologist said that the MRI showed

a typical picture for an alzheimer's patient but with the memory test that he

gave her it was looking like Lewy Body Disease. He has her on Exelon and

Seroquel. She has her good days and bad. She does fair well in the morning

times but in the afternoon times she starts getting pretty confused. She keeps

thinking she has to go to her other house to check on her mother. The other

house is the house she grew up in and her mother has been dead for 4 years now.

I tell her and she says that she would have remembered something like that. She

never mentions my Dad anymore. It's just confusing for me and my sisters right

now. I hope that next time he can tell more about what's going on. My mom has

really taken a down hill swing in the last three years.

Thanks for asking. It helps when others are concerned about asking.

Jackie

Re: LBD/atypical Parkinsins/broken arm

Hello!

I am so happy to have found this email list. I wish I had searched for it

before, but I wasn't aware that my Dad had this form of dementia until

recently. We knew he had dementia, and that it was progressing, but did not

have enough info about the LBD. I just purchased a laptop so that I can

log

on from Mom and Pop's house. I'm there every day now. I have been reading

your posts with great interest. It has been a comfort.

This list would have helped us so much in the earlier days when we were so

completely baffled by his dementia. The ups and downs were a true emotional

roller coaster ride. We would have coped better had we known more about

this

disease. Poor mom would get so hopeful every time he seemed to rally.

Until

very recently, she never lost hope that he'd get better somehow -- a cure,

a

miracle... anything!

He has suffered from atypical Parkinsons since his late 50's. He is 67 now,

and he has now reached the point where he is bedridden. We are caring for

him at home. His verbal abilities are almost nil now. Now we're trying to

move him around to prevent pneumonia. He cannot move at all now.

The latest extreme decline came after he got out of bed by himself, fell,

and broke his arm quite badly. The dementia spiraled out of control after

that incident. Now he has pain to deal with! I spoke with his orthopedic

surgeon yesterday. It's a bad break which normally requires surgery so that

the patient can regain function. Well, he has no function anyway and the

surgery would be so risky. Additionally, the pain would be worse for quite

some time. So, we're going to manage let it keep healing, manage the pain,

and keep him as comfortable as possible.

I'm so glad to have found you!

Love,

[Guest guest]

Jackie

Just as a suggestion when your mom asks about her old house and her

mother, you could try telling her that now isn't a good time to go that

maybe you could go later. I have learned, and then it was confirmed

through an Alzheimer's Association seminar, that even though this seems

like lying...as long as it is done for the good of the person, it is ok.

If family is to lie to get something out of their LO...money, property,

etc. that would not be for the good of the person. Helping them through

a thought or concern with redirecting them is different and ok. Hope it

is ok to suggest this.

With my dad, he doesn't talk much yet when I feel he is having an

hallucination and gets very frightened I confirm with him that what he

is seeing is very scary. I tell him I am sorry he has to see that and

go through that. I offer for him to hold my hand so we can go through

it together and if we are walking (when he walked more) we would turn

around, away from the fear to walk away from it.

Hope this helps. I am glad to see a post from you as I too was

wondering how you are doing.

Please post more as I look forward to seeing names in here and to have

the updates.

God Bless you!

Sandie

Des Moines, IA

[Guest guest]

Jackie

I am so glad that you are finding help in these groups. There is so

much " hands on experience " that I have found outweighs any medical

terminology. Please continue to keep us posted. Good Luck!

Sandie

[Guest guest]

Thanks Sandie for your concern. I have been posting to the alzheimer's and this

loop because I don't really don't know which catagory we fall under. Both are

helping a lot.

Jackie

Re: Jackie

Jackie

Just as a suggestion when your mom asks about her old house and her

mother, you could try telling her that now isn't a good time to go that

maybe you could go later. I have learned, and then it was confirmed

through an Alzheimer's Association seminar, that even though this seems

like lying...as long as it is done for the good of the person, it is ok.

If family is to lie to get something out of their LO...money, property,

etc. that would not be for the good of the person. Helping them through

a thought or concern with redirecting them is different and ok. Hope it

is ok to suggest this.

With my dad, he doesn't talk much yet when I feel he is having an

hallucination and gets very frightened I confirm with him that what he

is seeing is very scary. I tell him I am sorry he has to see that and

go through that. I offer for him to hold my hand so we can go through

it together and if we are walking (when he walked more) we would turn

around, away from the fear to walk away from it.

Hope this helps. I am glad to see a post from you as I too was

wondering how you are doing.

Please post more as I look forward to seeing names in here and to have

the updates.

God Bless you!

Sandie

Des Moines, IA

[Guest guest]

Hi Jackie. My MIL has some of the same experiences as your Mom. Before her

new meds, she too would have delusions of having to go somewhere right away.

Often she would talk to herself and if you asked her who she was taking to,

she would say her sister. It seems normal for these hallucinations and

delusions to occur. She has no short term memory left so when she goes to

the dentist or doctor, and if you ask her later that day how the appointment

went, she will say she didn't have any appointment. Before, when things

were really bad, she would carry knives saying people were in her house.

She had called 911 reporting 2 women were in her house trying to steal her

socks. It is so sad to see them go through this. Her meds are really doing

a great job right now. She still doesn't talk much, and she can't dress

herself. Some days she remembers how to brush her teeth, other mornings she

does not. She can feed herself, but needs help in the bath. Having good

doctors has made a vast difference.

I wish you the best and will keep you in my prayers.

Re: Jackie

Hi !

Thanks for asking but you might not want to know. My mother is 81 years old

and we don't really have a diagnosis yet. Her neurologist said that the MRI

showed a typical picture for an alzheimer's patient but with the memory test

that he gave her it was looking like Lewy Body Disease. He has her on

Exelon and Seroquel. She has her good days and bad. She does fair well in

the morning times but in the afternoon times she starts getting pretty

confused. She keeps thinking she has to go to her other house to check on

her mother. The other house is the house she grew up in and her mother has

been dead for 4 years now. I tell her and she says that she would have

remembered something like that. She never mentions my Dad anymore. It's

just confusing for me and my sisters right now. I hope that next time he

can tell more about what's going on. My mom has really taken a down hill

swing in the last three years.

Thanks for asking. It helps when others are concerned about asking.

Jackie

Re: LBD/atypical Parkinsins/broken arm

Hello!

I am so happy to have found this email list. I wish I had searched for it

before, but I wasn't aware that my Dad had this form of dementia until

recently. We knew he had dementia, and that it was progressing, but did

not

have enough info about the LBD. I just purchased a laptop so that I can

log

on from Mom and Pop's house. I'm there every day now. I have been reading

your posts with great interest. It has been a comfort.

This list would have helped us so much in the earlier days when we were so

completely baffled by his dementia. The ups and downs were a true

emotional

roller coaster ride. We would have coped better had we known more about

this

disease. Poor mom would get so hopeful every time he seemed to rally.

Until

very recently, she never lost hope that he'd get better somehow -- a cure,

a

miracle... anything!

He has suffered from atypical Parkinsons since his late 50's. He is 67

now,

and he has now reached the point where he is bedridden. We are caring for

him at home. His verbal abilities are almost nil now. Now we're trying to

move him around to prevent pneumonia. He cannot move at all now.

The latest extreme decline came after he got out of bed by himself, fell,

and broke his arm quite badly. The dementia spiraled out of control after

that incident. Now he has pain to deal with! I spoke with his orthopedic

surgeon yesterday. It's a bad break which normally requires surgery so

that

the patient can regain function. Well, he has no function anyway and the

surgery would be so risky. Additionally, the pain would be worse for quite

some time. So, we're going to manage let it keep healing, manage the

pain,

and keep him as comfortable as possible.

I'm so glad to have found you!

Love,

[Guest guest]

Hi Jackie. My MIL has some of the same experiences as your Mom. Before her

new meds, she too would have delusions of having to go somewhere right away.

Often she would talk to herself and if you asked her who she was taking to,

she would say her sister. It seems normal for these hallucinations and

delusions to occur. She has no short term memory left so when she goes to

the dentist or doctor, and if you ask her later that day how the appointment

went, she will say she didn't have any appointment. Before, when things

were really bad, she would carry knives saying people were in her house.

She had called 911 reporting 2 women were in her house trying to steal her

socks. It is so sad to see them go through this. Her meds are really doing

a great job right now. She still doesn't talk much, and she can't dress

herself. Some days she remembers how to brush her teeth, other mornings she

does not. She can feed herself, but needs help in the bath. Having good

doctors has made a vast difference.

I wish you the best and will keep you in my prayers.

Re: Jackie

Hi !

Thanks for asking but you might not want to know. My mother is 81 years old

and we don't really have a diagnosis yet. Her neurologist said that the MRI

showed a typical picture for an alzheimer's patient but with the memory test

that he gave her it was looking like Lewy Body Disease. He has her on

Exelon and Seroquel. She has her good days and bad. She does fair well in

the morning times but in the afternoon times she starts getting pretty

confused. She keeps thinking she has to go to her other house to check on

her mother. The other house is the house she grew up in and her mother has

been dead for 4 years now. I tell her and she says that she would have

remembered something like that. She never mentions my Dad anymore. It's

just confusing for me and my sisters right now. I hope that next time he

can tell more about what's going on. My mom has really taken a down hill

swing in the last three years.

Thanks for asking. It helps when others are concerned about asking.

Jackie

Re: LBD/atypical Parkinsins/broken arm

Hello!

I am so happy to have found this email list. I wish I had searched for it

before, but I wasn't aware that my Dad had this form of dementia until

recently. We knew he had dementia, and that it was progressing, but did

not

have enough info about the LBD. I just purchased a laptop so that I can

log

on from Mom and Pop's house. I'm there every day now. I have been reading

your posts with great interest. It has been a comfort.

This list would have helped us so much in the earlier days when we were so

completely baffled by his dementia. The ups and downs were a true

emotional

roller coaster ride. We would have coped better had we known more about

this

disease. Poor mom would get so hopeful every time he seemed to rally.

Until

very recently, she never lost hope that he'd get better somehow -- a cure,

a

miracle... anything!

He has suffered from atypical Parkinsons since his late 50's. He is 67

now,

and he has now reached the point where he is bedridden. We are caring for

him at home. His verbal abilities are almost nil now. Now we're trying to

move him around to prevent pneumonia. He cannot move at all now.

The latest extreme decline came after he got out of bed by himself, fell,

and broke his arm quite badly. The dementia spiraled out of control after

that incident. Now he has pain to deal with! I spoke with his orthopedic

surgeon yesterday. It's a bad break which normally requires surgery so

that

the patient can regain function. Well, he has no function anyway and the

surgery would be so risky. Additionally, the pain would be worse for quite

some time. So, we're going to manage let it keep healing, manage the

pain,

and keep him as comfortable as possible.

I'm so glad to have found you!

Love,

[Guest guest]

Jackie,

This sounds so hard. I'm so sorry that you have to go through all of that.

It is confusing and so hard to figure out how to respond. We went through

that sort of thing. Dad would be resting in the living room and ask, " How

are we going to afford this building. " He didn't even recognize it as home.

Back then, we would try to remind him that he's in the house that he owns,

and that he paid for in full. Later we learned to just distract him onto a

different topic.

Love,

Reply-To: LBDcaregivers

Date: Thu, 12 Sep 2002 12:01:20 -0400

To: <LBDcaregivers >

Subject: Re: Jackie

Hi !

Thanks for asking but you might not want to know. My mother is 81 years old

and we don't really have a diagnosis yet. Her neurologist said that the MRI

showed a typical picture for an alzheimer's patient but with the memory test

that he gave her it was looking like Lewy Body Disease. He has her on

Exelon and Seroquel. She has her good days and bad. She does fair well in

the morning times but in the afternoon times she starts getting pretty

confused. She keeps thinking she has to go to her other house to check on

her mother. The other house is the house she grew up in and her mother has

been dead for 4 years now. I tell her and she says that she would have

remembered something like that. She never mentions my Dad anymore. It's

just confusing for me and my sisters right now. I hope that next time he

can tell more about what's going on. My mom has really taken a down hill

swing in the last three years.

Thanks for asking. It helps when others are concerned about asking.

Jackie

Re: LBD/atypical Parkinsins/broken arm

Hello!

I am so happy to have found this email list. I wish I had searched for it

before, but I wasn't aware that my Dad had this form of dementia until

recently. We knew he had dementia, and that it was progressing, but did not

have enough info about the LBD. I just purchased a laptop so that I can

log

on from Mom and Pop's house. I'm there every day now. I have been reading

your posts with great interest. It has been a comfort.

This list would have helped us so much in the earlier days when we were so

completely baffled by his dementia. The ups and downs were a true emotional

roller coaster ride. We would have coped better had we known more about

this

disease. Poor mom would get so hopeful every time he seemed to rally.

Until

very recently, she never lost hope that he'd get better somehow -- a cure,

a

miracle... anything!

He has suffered from atypical Parkinsons since his late 50's. He is 67 now,

and he has now reached the point where he is bedridden. We are caring for

him at home. His verbal abilities are almost nil now. Now we're trying to

move him around to prevent pneumonia. He cannot move at all now.

The latest extreme decline came after he got out of bed by himself, fell,

and broke his arm quite badly. The dementia spiraled out of control after

that incident. Now he has pain to deal with! I spoke with his orthopedic

surgeon yesterday. It's a bad break which normally requires surgery so that

the patient can regain function. Well, he has no function anyway and the

surgery would be so risky. Additionally, the pain would be worse for quite

some time. So, we're going to manage let it keep healing, manage the pain,

and keep him as comfortable as possible.

I'm so glad to have found you!

Love,

[Guest guest]

Jackie

Just wanted to pass on that I have been taking Zoloft for over a

year...have had many deaths in our family and many other struggles. It

does seem to allow me to cope easier and see the light at the end of the

tunnel. Today, again, life isn't so heavy. The struggles just seem to

come and go especially when I am reminded of my dad. It is odd to me

though, when my mom passed away I was 19 (turned 20 5 months later) and

handled everything so differently. I was very close to my mom, she was

my very best friend. I have always been daddy's little girl as well,

and with all the caregiving, wow, what a loss. It also seems so

different losing my last parent. I am coping and surviving and still

know of the many wonders and beauty of life. Life is too precious and

short not to live it to its fullest.

Take Care-

Sandie

[Guest guest]

You'd think they'd find something safer to use, doctors can be so scary, or I should say the meds they prescribe..How's she doing today? Some better, I hope? How are YOU holding up? All pretty much the same here, am down to 4 in rehab, but the 2nd half of baby season starting now, there will be more, at least through September or so.. Hope today is a better day for all.. Love, Sheena Jackie on wrote: I dont know Sheena,, it is possible cuz this antibiotic, Levaquin is what gave BOTH my parents s s syndrome,, but the symptoms were entirely different.. Yep, we're both exhausted.. but she did keep some nausea medication down and ate 2 crackers,, and now Im working on getting some chicken noodle soup down her so she can take the meds she needs to before bed,, but she is soooooo grouchy,, Im trying hard NOT to take it personally but no matter what any of us talk about, she gets her knickers in a wad,, lol,, I sure hope tomorrow will be better!!!

lol,thanks honey for all your concerns,,, AND,, how are you? How is your hubby doing and how many babies do you have right now?Sheena <mom4possums2002> wrote: Jackie, could the antibiotics they have her on also be making her that sick? I sure hope she is doing better tonight, know you all must be so exhausted.. Love, Sheena Jackie on <redjaxjm> wrote: I spoke with her a couple of min ago and she said she threw up last nite and again early this morning,, so I dont know.. Im trying to answer emails and then Im headed up there.. my mom needs me to go to the pharmacy for her too,, its always something liz,, lolelizabethnv1 <elizabethnv1earthlink (DOT) net> wrote: Hahaha I thought you'd get a kick out this . How is your daughter today ? Re: Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection

Not F I N A L L Y !!!! <elizabethnv1earthlink (DOT) net> wrote: Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection Not Responding to Peginterferon/Ribavirin TherapyReported by Jules LevinDDW May 21, 2008, San Diego-Matthias Scherzer, Harald Hofer, Maximilian Schoeniger-Hekele, Petra Steindl-Munda, FerenciInternal Medicine 3, Dept of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, AustriaABSTRACT from program book.Results were reported at EASL, April 2008BACKROUND: Silibinin (SIL) is the main flavonoid extracted from milk thistle (Silibum marianum G.). Without a precise knowledge of its mode

of action it can show beneficial effects in various liver diseases. Recently it was shown that SIL inhibited viral replication in the Replicon® system (Gastroenterology 2007;132:1925). In the present study we investigated the antiviral activity of SIL in patients with chronic hepatitis C who did not respond to a previous course of standard PegIFN/RBV combination therapy. METHODS: 16 nonresponder (12 male; age: 49.9±9.7 (years, mean±SD); HCV-1: n=14; HCV-4: n=2; stage of fibrosis: F3/4: n=13, F1/2: n=3; 2 pts showed a > 2 log decline of viral load at wk 12 during the preceding therapy, none had an end of treatment response) were included. Since the efficacy of oral administration is limited by its low bioavailability treatment was started with 10mg/kg Silibinin (Legalon Sil®, Madaus, Köln) infused over 4 hrs for 7 days. On day 8 treatment was changed to 140 mg Silymarin (Legalon®, Madaus, Köln) TID per os in

combination with 180µg/wk PegIFN α-2a (PEGASYS®;Roche, Basel),1-1.2 g/d ribavirin (COPEGUS®; Roche, Basel). HCV-RNA was quantified by the TaqMan® assay (Roche Diagnostics) at baseline (BL), after 7 days of SIL iv. and every 2 wks on PegINF/RBV therapy, respectively. RESULTS: On iv. SIL-monotherapy all pts showed a substantial HCV RNA decline (BL: 6.68±5.69 day 8: 0.53±0.65 MIU/ml, (mean±SD, p<0.001) with a mean log decline of 1.32±0.55 within one wk. In parallel, ALT decreased from 162±133 to 118±107 U/l (mean±SD; p=0.004). In 3 patients viral kinetics were performed and showed a linear HCV RNA decline starting at day 3. Beside mild GI symptoms iv. SIL-monotherapy was well tolerated. After initiation of PegIFN/RBV the decrease of HCV-RNA was maintained (log drop: week 2: 1.17±0.67, week 4: 1.39±0.72; week 8: 1.47±0.86; all p<0.001 vs. BL). At the time

of the meeting data amended 2 wk regimes with iv. SIL at doses of 5 mg/kg, 10mg/kg and 15 mg/kg will be available. CONCLUSION: Intravenous SIL monotherapy is well tolerated and shows a substantial antiviral effect in chronic hepatitis C patients not responding to standard combination therapy. Thus, this drug may be useful for HCV treatment, especially in nonresponders or in combination with new antivirals. The antiviral effect of high dose iv SIL was not maintained on PegIFN/RBV therapy given together with a low dose oral preparation of SIL.EASL REPORT (5-20 mg dosing)SILIBININ IS A POTENT ANTIVIRAL AGENT IN CHRONIC HEPATITIS C NOT RESPONDING TO ANTIVIRAL COMBINATION THERAPY - (05/02/08)--------------------------------------------------------------------Jackie Jackie Jackie

[Guest guest]

Well she is better in that she has stopped throwing up,, so far..... but she is still very nauseated and her belly still hurts.. Im holding up fine honey, thank you for asking too! I slept pretty good last nite inspite of it being so windy that it kept causing the drapes to hit me in the face as I slept..lol... Well I hope you dont get overloaded with babies yourself, its a huge responsibility to have to get up and feed them around the clock... Hows Terry doing? Better I hope.. Well I will check in later on today,, jaxSheena wrote: You'd think they'd find something safer to use, doctors can be so scary, or I should say the meds they prescribe..How's she doing today? Some better, I hope? How are YOU holding up? All pretty much the same here, am down to 4 in rehab, but the 2nd half of baby season starting now, there will be more, at least through September or so.. Hope today is a better day for all.. Love, Sheena Jackie on <redjaxjm> wrote: I dont know Sheena,, it is possible cuz this antibiotic, Levaquin is what gave BOTH my parents s s syndrome,, but the symptoms were entirely different.. Yep, we're both exhausted.. but she did keep some nausea medication down and ate 2 crackers,, and now Im working on getting some chicken noodle soup down her so she can take the meds she needs to before bed,, but she is soooooo grouchy,, Im trying hard NOT to take it personally but no matter what any of us talk about, she gets her knickers in a wad,, lol,, I sure hope tomorrow will be better!!! lol,thanks honey for all your concerns,,, AND,, how are you? How is your hubby doing and how many babies do you have right now?Sheena <mom4possums2002>

wrote: Jackie, could the antibiotics they have her on also be making her that sick? I sure hope she is doing better tonight, know you all must be so exhausted.. Love, Sheena Jackie on <redjaxjm> wrote: I spoke with her a couple of min ago and she said she threw up last nite and again early this morning,, so I dont know.. Im trying to

answer emails and then Im headed up there.. my mom needs me to go to the pharmacy for her too,, its always something liz,, lolelizabethnv1 <elizabethnv1earthlink (DOT) net> wrote: Hahaha I thought you'd get a kick out this . How is your daughter today ? Re: Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection Not F I N A L L Y !!!! <elizabethnv1earthlink (DOT) net> wrote:

Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection Not Responding to Peginterferon/Ribavirin TherapyReported by Jules LevinDDW May 21, 2008, San Diego-Matthias Scherzer, Harald Hofer, Maximilian Schoeniger-Hekele, Petra Steindl-Munda, FerenciInternal Medicine 3, Dept of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, AustriaABSTRACT from program book.Results were reported at EASL, April 2008BACKROUND: Silibinin (SIL) is the main flavonoid extracted from milk thistle (Silibum marianum G.). Without a precise knowledge of its mode of action it can show beneficial effects in various liver diseases. Recently it was shown that SIL inhibited viral replication in the Replicon® system (Gastroenterology 2007;132:1925). In the

present study we investigated the antiviral activity of SIL in patients with chronic hepatitis C who did not respond to a previous course of standard PegIFN/RBV combination therapy. METHODS: 16 nonresponder (12 male; age: 49.9±9.7 (years, mean±SD); HCV-1: n=14; HCV-4: n=2; stage of fibrosis: F3/4: n=13, F1/2: n=3; 2 pts showed a > 2 log decline of viral load at wk 12 during the preceding therapy, none had an end of treatment response) were included. Since the efficacy of oral administration is limited by its low bioavailability treatment was started with 10mg/kg Silibinin (Legalon Sil®, Madaus, Köln) infused over 4 hrs for 7 days. On day 8 treatment was changed to 140 mg Silymarin (Legalon®, Madaus, Köln) TID per os in combination with 180µg/wk PegIFN α-2a (PEGASYS®;Roche, Basel),1-1.2 g/d ribavirin (COPEGUS®; Roche, Basel). HCV-RNA was quantified by the TaqMan® assay (Roche Diagnostics) at baseline

(BL), after 7 days of SIL iv. and every 2 wks on PegINF/RBV therapy, respectively. RESULTS: On iv. SIL-monotherapy all pts showed a substantial HCV RNA decline (BL: 6.68±5.69 day 8: 0.53±0.65 MIU/ml, (mean±SD, p<0.001) with a mean log decline of 1.32±0.55 within one wk. In parallel, ALT decreased from 162±133 to 118±107 U/l (mean±SD; p=0.004). In 3 patients viral kinetics were performed and showed a linear HCV RNA decline starting at day 3. Beside mild GI symptoms iv. SIL-monotherapy was well tolerated. After initiation of PegIFN/RBV the decrease of HCV-RNA was maintained (log drop: week 2: 1.17±0.67, week 4: 1.39±0.72; week 8: 1.47±0.86; all p<0.001 vs. BL). At the time of the meeting data amended 2 wk regimes with iv. SIL at doses of 5 mg/kg, 10mg/kg and 15 mg/kg will be available. CONCLUSION: Intravenous SIL monotherapy is well tolerated and shows a

substantial antiviral effect in chronic hepatitis C patients not responding to standard combination therapy. Thus, this drug may be useful for HCV treatment, especially in nonresponders or in combination with new antivirals. The antiviral effect of high dose iv SIL was not maintained on PegIFN/RBV therapy given together with a low dose oral preparation of SIL.EASL REPORT (5-20 mg dosing)SILIBININ IS A POTENT ANTIVIRAL AGENT IN CHRONIC HEPATITIS C NOT RESPONDING TO ANTIVIRAL COMBINATION THERAPYÂ - (05/02/08)--------------------------------------------------------------------Jackie Jackie Jackie Jackie

[Guest guest]

My daughter is like that when she's ill or down, it's all about her. I was taught NOT to let it show, generational difference, I guess. This generation is not as stoic as we were. I'm very glad to hear she is doing better, Jackie, If it were my daughter, I would be concerned too.

I just got home from the second cataract surgery and can read and type better with my BAD eye, while the GOOD eye is still closed from surgery. I'm thrilled.

Sharon in NW Washington

Knitting is...time and love made tangible. Alison Hyde

----- Original Message -----

From: Jackie on

I dont know Sheena,, it is possible cuz this antibiotic, Levaquin is what gave BOTH my parents s s syndrome,, but the symptoms were entirely different.. Yep, we're both exhausted.. but she did keep some nausea medication down and ate 2 crackers,, and now Im working on getting some chicken noodle soup down her so she can take the meds she needs to before bed,, but she is soooooo grouchy,, Im trying hard NOT to take it personally but no matter what any of us talk about, she gets her knickers in a wad,, lol,, I sure hope tomorrow will be better!!! lol,thanks honey for all your concerns,,, AND,, how are you? How is your hubby doing and how many babies do you have right now?

[Guest guest]

Oh Sharon, Im so glad you got that cataract fixed and in a couple of days, you will have better vision.. I hated it when my eye was closed with that metal eye protector for 24 hours after surgery.. it WILL be better... you are right,, kids today are not good sick ppl,, lol,,, and it very well may be generational as you said,, when Im sick, I stay asleep,, take care of that eye sharon,, and when you can, get the other one fixed too..SHARON CROSBY wrote: My daughter is like that when she's ill or down, it's all about her. I was taught NOT to let it show, generational difference, I guess. This generation is not as stoic as we were. I'm very glad to hear she is doing better, Jackie, If it were my daughter, I would be concerned too. I just got home from the second cataract surgery and can read and type better with my BAD eye, while the GOOD eye is still closed from surgery. I'm thrilled. Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde ----- Original Message ----- From: Jackie on I dont know

Sheena,, it is possible cuz this antibiotic, Levaquin is what gave BOTH my parents s s syndrome,, but the symptoms were entirely different.. Yep, we're both exhausted.. but she did keep some nausea medication down and ate 2 crackers,, and now Im working on getting some chicken noodle soup down her so she can take the meds she needs to before bed,, but she is soooooo grouchy,, Im trying hard NOT to take it personally but no matter what any of us talk about, she gets her knickers in a wad,, lol,, I sure hope tomorrow will be better!!! lol,thanks honey for all your concerns,,, AND,, how are you? How is your hubby doing and how many babies do you have right now? Jackie

[Guest guest]

All they use now to keep the eye closed is a piece of paper tape, which one can take off as soon as the eye "wakes up". I can see from it, but the vision is lopsided, so that will take a couple of days.

Has your daughter improved?

Sharon in NW Washington

Knitting is...time and love made tangible. Alison Hyde

Re: Jackie

Oh Sharon, Im so glad you got that cataract fixed and in a couple of days, you will have better vision.. I hated it when my eye was closed with that metal eye protector for 24 hours after surgery.. it WILL be better...

you are right,, kids today are not good sick ppl,, lol,,, and it very well may be generational as you said,, when Im sick, I stay asleep,,

take care of that eye sharon,, and when you can, get the other one fixed too..

[Guest guest]

thats cool then,, maybe they used the protective cup on my eye because they did more than replace the lense ,, they did a second vitrectomy and had to scrape off that sarcoid membrane,, but once they took the cover off,, wow,, it was so clear.. no longer had that yellowish foggy cast to everything,,SHARON CROSBY wrote: All they use now to keep the eye closed is a piece of paper tape, which one can take off as soon as

the eye "wakes up". I can see from it, but the vision is lopsided, so that will take a couple of days. Has your daughter improved? Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Re: Jackie Oh Sharon, Im so glad you got that cataract fixed and in a couple of days, you will have better vision.. I hated it when my eye was closed with that metal eye protector for 24 hours after surgery.. it WILL be better... you are right,,

kids today are not good sick ppl,, lol,,, and it very well may be generational as you said,, when Im sick, I stay asleep,, take care of that eye sharon,, and when you can, get the other one fixed too.. Jackie

[Guest guest]

Yeah, my glasses are worthless now, can't see a thing with them. Gotta ait til next week to see THAT doc and get a new prescription and then wait for the script to be ready....I'm wasting valuable knitting time here. lol I started a garter stitch blanket for my daughter, don't have to see for that

Sharon in NW Washington

Knitting is...time and love made tangible. Alison Hyde

Re: Jackie

thats cool then,, maybe they used the protective cup on my eye because they did more than replace the lense ,, they did a second vitrectomy and had to scrape off that sarcoid membrane,, but once they took the cover off,, wow,, it was so clear.. no longer had that yellowish foggy cast to everything,,SHARON CROSBY wrote:

All they use now to keep the eye closed is a piece of paper tape, which one can take off as soon as the eye "wakes up". I can see from it, but the vision is lopsided, so that will take a couple of days.

Has your daughter improved?

Sharon in NW Washington

Knitting is...time and love made tangible. Alison Hyde

[Guest guest]

well once you get new glasses and you actually get them, you'll do great!! Yeah, I do understand not needing to see to do the garter stitch,, are you making several blocks to sew together or one big block? If you can, take a picture and post it so we can see what you've made!SHARON CROSBY wrote: Yeah, my glasses are worthless now, can't see a thing with them. Gotta ait til next week to see THAT doc and get a

new prescription and then wait for the script to be ready....I'm wasting valuable knitting time here. lol I started a garter stitch blanket for my daughter, don't have to see for that Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Re: Jackie thats cool

then,, maybe they used the protective cup on my eye because they did more than replace the lense ,, they did a second vitrectomy and had to scrape off that sarcoid membrane,, but once they took the cover off,, wow,, it was so clear.. no longer had that yellowish foggy cast to everything,,SHARON CROSBY <csharonxoxomsn> wrote: All they use now to keep the eye closed is a piece of paper tape, which one can take off as soon as the eye "wakes up". I can see from it, but the vision is lopsided, so that will take a couple of days. Has your daughter improved? Sharon in NW Washington Knitting is...time and love made

tangible. Alison Hyde Jackie

[Guest guest]

No, nothing fancy, just the dishcloth afghan, from one corner diagonally to the opposite corner, all one piece.I can't wait for the glasses...This is the first time in over 50 years I have been able to see this well without glasses...life is good.Sharon in NW Washington Knitting is...time and love made tangible. Alison HydeSubject: Re: Jackiewell once you get new glasses and you actually get them, you'll do great!! Yeah, I do understand not needing to see to do the garter stitch,, are you making several blocks to sew together or one big block? If you can, take a picture and post it so we can see what you've made!

[Guest guest]

Oooo I bet it is going to be pretty. I love to crochet. I don't have the patience to do big projects but I have made a table cloth one time. And every body loved it. I might make another one for everyday. The one I made was for Christmas time. I always get big compliments when I put it out. Love JanetSHARON CROSBY wrote: Yeah, my glasses are worthless now, can't see a thing with them. Gotta ait til next week to see THAT doc and get a new prescription and then wait for the script to be ready....I'm wasting valuable knitting time here. lol I started a garter stitch blanket for my daughter, don't have to see for that Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Re: Jackie thats cool then,, maybe they used the protective cup on my eye because they did more than replace the lense ,, they did a second vitrectomy and had to scrape off that sarcoid membrane,, but once they took the cover off,, wow,, it was so clear.. no longer had that yellowish foggy cast to everything,,SHARON CROSBY <csharonxoxomsn> wrote: All they use now to keep the eye closed is a piece of

paper tape, which one can take off as soon as the eye "wakes up". I can see from it, but the vision is lopsided, so that will take a couple of days. Has your daughter improved? Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde "There are souls in this world that have the gift of finding joy everywhere and of leaving it behind them when they go" Frederick Faber

[Guest guest]

well yeah,, life IS good,, and it sounds really cute,, that afghan,, I hope you will post a pic for me to see it when you get it done,, right now Im working on knitting socks, I have grown to love knitting socks,, they are not the kind you wear in shoes but kind of like 'slipper socks',, SHARON CROSBY wrote: No, nothing fancy, just the dishcloth afghan, from one corner diagonally to the opposite corner, all one piece.

I can't wait for the glasses...This is the first time in over 50 years I have been able to see this well without glasses...life is good. Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Subject: Re: Jackie well once you get new glasses and you actually get them, you'll do great!! Yeah, I do understand not needing to see to do the garter stitch,, are you making several blocks to sew together or one big block? If you can, take a picture and post it so we can see what you've made! Jackie

[Guest guest]

I've crocheted for many years, probably 45 or so, but it bothers my wrists now with age, so it's knitting that's the passion now. I WILL post a pic when it's done.Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Re: JackieOooo I bet it is going to be pretty. I love to crochet. I don't have the patience to do big projects but I have made a table cloth one time. And every body loved it. I might make another one for everyday. The one I made was for Christmas time. I always get big compliments when I put it out.LoveJanet

[Guest guest]

Cool beans Sharon,, when I can post some pics of my socks, Ill post them too,, SHARON CROSBY wrote: I've crocheted for many years, probably 45 or so, but it bothers my wrists now with age, so it's knitting that's the passion now. I WILL post a pic when it's done. Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Re: Jackie Oooo I bet it is going to be pretty. I love to crochet. I don't have the patience to do big projects but I have made a table cloth one time. And every body loved it. I might make another one for everyday. The one I made was for Christmas time. I always get big compliments when I put it out. Love Janet Jackie

[Guest guest]

OL, I'll post the pic of my very first sock, finished about 3 weeks ago. Sharon in NW Washington Knitting is...time and love made tangible. Alison Hyde Re: JackieOooo I bet it is going to be pretty. I love to crochet. I don't have the patience to do big projects but I have made a table cloth one time. And every body loved it. I might make another one for everyday. The one I made was for Christmas time. I always get big compliments when I put it out.LoveJanetJackie

[Guest guest]

Is your daughter taking her meds with food? Any better today? I sure feel for both of you! Terry is the same..and still fighting for his disability, he did make it as far as the state doc recently... I had to remain mostly off line with all of our bad weather yesterday. My son was on the freeway when the tornado hit, talk about nutty weather in Southern California.. O' fur babies rarely have to be fed all night, just sometimes the first night while rehydrating with ringers before formula can be introduced. They are pretty easy to care for, unless they have sick/injured issues.... Jackie on wrote: Well she is better in that she has stopped throwing up,, so far..... but she is still very nauseated and her belly still hurts.. Im holding up fine honey, thank you for asking too! I slept pretty good last nite inspite of it being so windy that it kept causing the drapes to hit me in the face as I slept..lol... Well I hope you dont get overloaded with

babies yourself, its a huge responsibility to have to get up and feed them around the clock... Hows Terry doing? Better I hope.. Well I will check in later on today,, jaxSheena <mom4possums2002> wrote: You'd think they'd find something safer to use, doctors can be so scary, or I should say the meds they prescribe..How's she doing today? Some better, I hope? How are YOU holding up? All pretty much the same here, am down to 4 in rehab, but the 2nd half of baby season starting now, there will be more, at

least through September or so.. Hope today is a better day for all.. Love, Sheena Jackie on <redjaxjm> wrote: I dont know Sheena,, it is possible cuz this antibiotic, Levaquin is what gave BOTH my parents s s syndrome,, but the symptoms were entirely different.. Yep, we're both exhausted.. but she did keep some nausea medication down and ate 2 crackers,, and now Im working on getting some chicken noodle soup down her so she can take the meds she needs to before bed,, but she is soooooo grouchy,, Im trying hard NOT to take it personally but no matter what any of us talk about, she gets her

knickers in a wad,, lol,, I sure hope tomorrow will be better!!! lol,thanks honey for all your concerns,,, AND,, how are you? How is your hubby doing and how many babies do you have right now?Sheena <mom4possums2002> wrote: Jackie, could the antibiotics they have her on also be making her that sick? I sure hope she is doing better tonight, know you all must be so exhausted.. Love, Sheena Jackie on

<redjaxjm> wrote: I spoke with her a couple of min ago and she said she threw up last nite and again early this morning,, so I dont know.. Im trying to answer emails and then Im headed up there.. my mom needs me to go to the pharmacy for her too,, its always something liz,, lolelizabethnv1 <elizabethnv1earthlink (DOT) net> wrote: Hahaha I thought you'd get a kick out this . How is your daughter today ? Re:

Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection Not F I N A L L Y !!!! <elizabethnv1earthlink (DOT) net> wrote: Silibinin Is a Potent Antiviral Agent in Patients with Chronic HCV Infection Not Responding to Peginterferon/Ribavirin TherapyReported by Jules LevinDDW May 21, 2008, San Diego-Matthias Scherzer, Harald Hofer, Maximilian Schoeniger-Hekele, Petra Steindl-Munda, FerenciInternal Medicine 3, Dept of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, AustriaABSTRACT from program book.Results were reported at EASL, April 2008BACKROUND: Silibinin (SIL) is the main

flavonoid extracted from milk thistle (Silibum marianum G.). Without a precise knowledge of its mode of action it can show beneficial effects in various liver diseases. Recently it was shown that SIL inhibited viral replication in the Replicon® system (Gastroenterology 2007;132:1925). In the present study we investigated the antiviral activity of SIL in patients with chronic hepatitis C who did not respond to a previous course of standard PegIFN/RBV combination therapy. METHODS: 16 nonresponder (12 male; age: 49.9±9.7 (years, mean±SD); HCV-1: n=14; HCV-4: n=2; stage of fibrosis: F3/4: n=13, F1/2: n=3; 2 pts showed a > 2 log decline of viral load at wk 12 during the preceding therapy, none had an end of treatment response) were included. Since the efficacy of oral administration is limited by its low bioavailability treatment was started with 10mg/kg Silibinin (Legalon Sil®, Madaus, Köln) infused over 4

hrs for 7 days. On day 8 treatment was changed to 140 mg Silymarin (Legalon®, Madaus, Köln) TID per os in combination with 180µg/wk PegIFN α-2a (PEGASYS®;Roche, Basel),1-1.2 g/d ribavirin (COPEGUS®; Roche, Basel). HCV-RNA was quantified by the TaqMan® assay (Roche Diagnostics) at baseline (BL), after 7 days of SIL iv. and every 2 wks on PegINF/RBV therapy, respectively. RESULTS: On iv. SIL-monotherapy all pts showed a substantial HCV RNA decline (BL: 6.68±5.69 day 8: 0.53±0.65 MIU/ml, (mean±SD, p<0.001) with a mean log decline of 1.32±0.55 within one wk. In parallel, ALT decreased from 162±133 to 118±107 U/l (mean±SD; p=0.004). In 3 patients viral kinetics were performed and showed a linear HCV RNA decline starting at day 3. Beside mild GI symptoms iv. SIL-monotherapy was well tolerated. After initiation of PegIFN/RBV the decrease of HCV-RNA was maintained (log

drop: week 2: 1.17±0.67, week 4: 1.39±0.72; week 8: 1.47±0.86; all p<0.001 vs. BL). At the time of the meeting data amended 2 wk regimes with iv. SIL at doses of 5 mg/kg, 10mg/kg and 15 mg/kg will be available. CONCLUSION: Intravenous SIL monotherapy is well tolerated and shows a substantial antiviral effect in chronic hepatitis C patients not responding to standard combination therapy. Thus, this drug may be useful for HCV treatment, especially in nonresponders or in combination with new antivirals. The antiviral effect of high dose iv SIL was not maintained on PegIFN/RBV therapy given together with a low dose oral preparation of SIL.EASL REPORT (5-20 mg dosing)SILIBININ IS A POTENT ANTIVIRAL AGENT IN CHRONIC HEPATITIS C NOT RESPONDING TO ANTIVIRAL COMBINATION THERAPY -

(05/02/08)--------------------------------------------------------------------Jackie Jackie Jackie Jackie

[Guest guest]

Do u need my email addy?