Fw: [Frontline Hepatitis2] Improving Outcomes of Liver Retransplantation

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[Frontline Hepatitis2] Improving Outcomes of Liver Retransplantation

American Journal of Transplantation 8 (2), 404–411. doi:10.1111/ j.1600-6143. 2007.02082. x AbstractImproving Outcomes of Liver Retransplantation: An Analysis of Trends and the Impact of Hepatitis C InfectionM. GhabrilaaDepartment of Gastroenterology and Hepatology, Mayo Clinic, ville, FL, R. Dicksona,*aDepartme nt of Gastroenterology and Hepatology, Mayo Clinic, ville, FL*Corresponding author: Rolland Dickson, dickson.rolland1@ mayo.edu and R. WiesnerbbDepartment of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MNaDepartment of Gastroenterology and Hepatology, Mayo Clinic, ville, FL bDepartment of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN*Corresponding author: Rolland Dickson, dickson.rolland1@ mayo.eduAbstractRetransplantation (RT) in Hepatitis C (HCV) patients remains controversial. Aims: To study trends in RT and evaluate the impact of HCV status in the context of a comprehensive recipient and donor risk assessment. The UNOS database between 1994 and October 2005 was utilized to analyze 46 982 LT and RT. Graft and patient survival along with patient and donor characteristics were compared for 2283 RT performed in HCV and non-HCV patients during 1994–1997, 1998–2001 and 2002–October 2005. Overall HCV prevalence at RT increased from 36% in the initial period to 40.6% after 2002. In our study group, 1-year patient and graft survival post-RT improved over the same time intervals from 65.0% to 70.7% and 54.87% to 65.8%, respectively. HCV was only associated with decreased patient and graft survival with a retransplant (LT-RT) interval (RI)>90 days. Independent predictors of mortality for RT with RI>90 days were patient age, MELD score>25, RI " No matter if I live or die, I am a rich Gypsy"

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Fw: [Frontline Hepatitis2] Improving Outcomes of Liver Retransplantation

What does the RI stand for folks???

[Frontline

Hepatitis2] Improving Outcomes of Liver Retransplantation

American Journal of

Transplantation 8 (2), 404–411.

doi:10.1111/ j.1600-6143. 2007.02082. x

Abstract

Improving Outcomes of Liver Retransplantation: An Analysis of Trends and the

Impact of Hepatitis C Infection

M. GhabrilaaDepartment of Gastroenterology and Hepatology, Mayo Clinic,

ville, FL, R. Dicksona,*aDepartme nt of Gastroenterology and Hepatology,

Mayo Clinic, ville, FL*Corresponding author: Rolland Dickson,

dickson.rolland1@ mayo.edu and R. WiesnerbbDepartment of Gastroenterology and

Hepatology, Mayo Clinic, Rochester, MNaDepartment of Gastroenterology and

Hepatology, Mayo Clinic, ville, FL bDepartment of Gastroenterology and

Hepatology, Mayo Clinic, Rochester, MN

*Corresponding author: Rolland Dickson, dickson.rolland1@ mayo.edu

Abstract

Retransplantation (RT) in Hepatitis C (HCV) patients remains controversial.

Aims: To study trends in RT and evaluate the impact of HCV status in the

context of a comprehensive recipient and donor risk assessment. The UNOS

database between 1994 and October 2005 was utilized to analyze 46 982 LT and

RT. Graft and patient survival along with patient and donor characteristics

were compared for 2283 RT performed in HCV and non-HCV patients during

1994–1997, 1998–2001 and 2002–October 2005. Overall HCV

prevalence at RT increased from 36% in the initial period to 40.6% after 2002.

In our study group, 1-year patient and graft survival post-RT improved over the

same time intervals from 65.0% to 70.7% and 54.87% to 65.8%, respectively. HCV

was only associated with decreased patient and graft survival with a

retransplant (LT-RT) interval (RI)>90 days. Independent predictors of

mortality for RT with RI>90 days were patient age, MELD score>25, RI

" No matter if I live or die, I am a rich Gypsy "