Inheritance Patterns in CMT

[Guest guest]

CMT can be inherited in various ways:

1) X-linked. In X-linked inheritance, the genetic defect (mutation)

is located on the X chromosome. X-linked diseases are passed from

mother to son through one of the mother's genes in a pattern called

X-linked recessive inheritance. A boy inherits an X chromosome from

his mother and a Y chromosome from his father. The X-Y combination

makes him male. A girl inherits two X chromosomes, one from her

mother and one from her father. The X-X combination makes her

female. Women who have a defective gene that causes a disorder are

simply carriers and exhibit no signs or symptoms of the disease. The

disease can skip a generation until another son inherits the

defective gene on the X chromosome.

2) Autosomal dominant. When the genetic defect occurs on a

chromosome other than X or Y, CMT affects males and females the

same. Autosomal dominant inheritance of CMT results when one copy of

the defective gene is enough to cause the disease. If either parent

carries the defective gene for CMT, there's a 50 percent chance the

disorder will be passed along to a child.

3) Autosomal recessive. Autosomal recessive inheritance occurs when

two copies of the defective gene are required to cause CMT. One copy

is inherited from each parent, neither actually having CMT.

Some types of CMT can pass from generation to generation and affect

males and females equally. In other cases of CMT, the disease arises

from a new or spontaneous mutation in a gene rather than from an

inherited defective gene, meaning there's no previous family history

of the disorder.

[Guest guest]

Hi,

In my case,My father is suffering from CMT.I am also CMT patient.My son is now

showing slight foot drop & muscle weakness.

Which Inheritance Patterns in CMT it may be?

There is no lab here to do genetic testing?

-Leena.