Neuromuscular complications of statins

[Guest guest]

Phys Med Rehabil Clin N Am. 2008 Feb;19(1):47-59.

Neuromuscular complications of statins.

Ahn SC.

943 Avenue, Oak Park, IL 60302-1411, USA; Loyola University,

2160 South 1st Avenue, Maywood, IL 60153-5500, USA.

Statins, 3-hydroxy-3-methlglutaryl coenzyme A reductase inhibitors,

are commonly prescribed for patients who have hyperlipidemia.

Statins were first approved in 1987. Statin therapy is well

documented to reduce serum low-density lipoprotein levels, incidence

of cardiovascular events, and mortality. Although statin therapy is

well tolerated, serious adverse affects have been reported,

including neuromuscular and hepatic complications. Myopathy is

particularly concerning because of the potential for rhabdomyolysis

and death. Recently, peripheral neuropathy also has been identified

as a possible complication. The incidence of neuromuscular

complications is expected to increase with the increased number of

people using statin therapy. Clinicians should be aware of the

potential neuromuscular complications. This article reviews

epidemiology, possible mechanisms, risk factors, and management of

statin-associated neuromuscular complications.

[Guest guest]

For those of you concerned about statins, my doctor prescribed 500 mg. of niacin

twice daily. To avoid flushing of skin and burning sensation, take with a

little applesauce or 4 or 5 Triskits. It works. I don't know why but it does.

Just thought I'd pass that along FWIW. (For what its worth).

Carl (currently in NC for 3 more weeks)