L-carnosine

[Guest guest]

<<Thirty-one children (21 M, mean age= 7.45;  range = 3.2-12.5 yrs )meeting

inclusion criteria were enrolled in an 8 week blinded trial of either 400 mg

BID powdered L-Carnosine or placebo. >>

Does this mean that 31 children total were studied? Or were 31 children

given placebo and 31 given the real thing?

Thanks,

[Guest guest]

,

It looks like it was 31 total children were studied. I would guess

that 21 were male and 10 were female. The age range would have

been 3 years 2 months to 12 years 5 months with the average age

approximately 7 1/2 years old. After ready the below abstract It

said that 17 were placebo and 14 received the study drug. I hope

this helps.

Theresa, SA

I wanted to make sure this was the main part of the study/abstract so

I found it at http://www.carn-aware.com/abstract.html

Design/Methods: Thirty-one children (21 M, mean age= 7.45; range =

3.2-12.5 yrs )meeting inclusion criteria were enrolled in an 8 week

blinded trial of either 400 mg BID powdered L-Carnosine or placebo.

Children were assessed at a pediatric neurology clinic with the

Childhood Autism Rating Scale (CARS), the Gilliam Autism Rating

Scale (GARS), the Expressive and Receptive One-Word Picture

Vocabulary tests (E/ROWPVT), and biweekly parental Clinical Global

Impression of Change (CGI), at baseline and 8 week endpoint.

Results: Children who were on placebo (n=17) did not show

statistically significant changes on any of the outcome measures.

After 8 weeks on L-Carnosine, children (n=14) showed statistically

significant improvements on the GARS total score, GARS Behavior,

Socialization, and Communication subscales, and the ROWPVT (all

p's<.05). EOWPVT and CARS showed trends in improvements, which were

supported by parental CGI.

Conclusions: Oral supplementation with L-Carnosine resulted in

demonstrable improvements in autistic behaviors as well as increases

in language comprehension that reached statistical significance.

Although the mechanism of action of the amino acid is not well

understood, it is believed that it acts to modulate neurotransmission

and affect metal ion transfer of zinc and copper in the entorhinal

cortex. This may enhance neurological function or act in a

neuroprotective fashion.

> <<Thirty-one children (21 M, mean age= 7.45;  range = 3.2-12.5 yrs )

meeting

> inclusion criteria were enrolled in an 8 week blinded trial of

either 400 mg

> BID powdered L-Carnosine or placebo. >>

>

> Does this mean that 31 children total were studied? Or were 31

children

> given placebo and 31 given the real thing?

> Thanks,

>

[Guest guest]

Thanks, Theresa!

Then I guess all 14 children who received the drug showed improvement? That

is pretty good.

[Guest guest]

I would love to hear more about this

TIA

Connie

L-Carnosine

> Hi. I'm a 36 year old autistic (Asperger's or HFA not sure which).

> I had tried assorted supplements and found a number helpful. I saw

> a rumor about Carnosine and gave it a try. This was 'the mother of all

> supplements', and has fairly substantially changed my life over the

> past few months. I've been hesistant to prothelitize (sp?) too much

> until I heard reports from other adults using it. So far the response

> from a small handful of autistic adults has consistently been positive.

> For myself it seemed to help significantly with sensory issues,

> expecially auditory, and with socializing, in higher doses it had

> a mild 'hyperactive' effect, something people have also noticed in

> children using it.

>

> I started off with 500mg/day and moved upto 750mg (taking 1/2 a 500mg

> capsule in the afternoon).

>

> I'm curious if anyone here has tried it?

>

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