Effects of dietary vitamin E, C and soybean oil supplementation on antioxidant e

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Food Chem Toxicol. 2008 Jul 29.

Effects of dietary vitamin E, C and soybean oil supplementation on

antioxidant enzyme activities in liver and muscles of rats.

Shireen KF, Pace RD, Mahboob M, Khan AT.

Department of Food and Nutritional Sciences, Tuskegee University,

Tuskegee, Alabama, USA.

The effect of elevated levels of dietary vitamin E, C and a

combination of vitamin E and C (E & C) with soybean oil on activities

of antioxidant (AOE) enzymes important in the protection against

lipid peroxidation was studied in male rats fed with vitamin C

(12mg/g), vitamin E (3.68mg/g) or E & C (3.68mg+12mg/g) supplemented

diets for 28 days.

Catalase (CAT), glutathione peroxidase (GPx) and glutathione

reductase (GR) activity in liver, pectoralis major (PM) and sartorius

(S) muscles was increased significantly in rats fed with dietary

vitamin C, E separately, and vitamin C & E combination, except,

superoxide dismutase (SOD), which showed no alterations.

These results clearly indicated that vitamin E & C separately and E & C

together increased AOE activity in liver, PM and S muscle of rats.

However, vitamin E and C combination enhanced AOE activity more

significantly and our findings suggest the possible role of vitamin

C & E and their combination in reducing the risk of chronic diseases

related to oxidative stress.