Ascorbic acid is a regulator of the intracellular cAMP concentration: Old molecu

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FEBS Lett. 2008 Sep 30.

Ascorbic acid is a regulator of the intracellular cAMP concentration:

Old molecule, new functions?

Kaya F, Belin S, Diamantidis G, Fontes M.

INSERM UMR EA4263, Medical Genetics, Faculté de Médecine de la Timone,

27 Bd. J. Moulin, 13385 Marseille cedex 5, France.

Recently, using an animal model of Charcot-Marie-Tooth human disorder,

we showed that ascorbic acid (AA) represses PMP22 gene expression by

acting on intracellular cAMP concentrations. In this work, we present

kinetics data on the inhibitory effect of AA upon adenylate cyclase

activity. The data show that this molecule acts as a competitive

inhibitor of the enzyme, a finding that opens new pharmacological

avenues.