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OT: Autism

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  • 5 years later...

Has anybody else seen the new(ish) movie " Gifted Hands " starring Cuba Gooding? 

Its about a surgeon at s Hopkins, & he operates on those with autism, &

other brain/neuro problems.  Its a GREAT movie.

Vicki

From: osisposis <jeaninem660@...>

Subject: [] OT: Autism

Date: Friday, January 1, 2010, 8:35 PM

2009 Aug;2(4):205- 19.

Decreased GABAA receptors and benzodiazepine binding sites in the anterior

cingulate cortex in autism.

Oblak A, Gibbs TT, Blatt GJ.

Boston University School of Medicine, Anatomy and Neurobiology, Boston,

Massachusetts 02118, USA. aoblak@...

Erratum in:

Autism Res. 2009 Aug;2(4):237.

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" the autistic group had significant decreases in the mean density of GABA

(A) receptors in the supragranular (46.8%) and infragranular (20.2%)

layers of the ACC and in the density of benzodiazepine binding sites in

the supragranular (28.9%) and infragranular (16.4%) lamina [corrected].

These findings suggest that in the autistic group this downregulation of

both benzodiazepine sites and GABA(A) receptors in the ACC may be the

result of increased GABA innervation and/or release disturbing the

delicate excitation/inhibition balance of principal neurons as well as

their output to key limbic cortical targets. Such disturbances likely

underlie the core alterations in socio-emotional behaviors in autism. "

does anyone know how this would affect how well benzo drugs would work?

I am curious because my sick family member, NOT autistic, was prescribed

benzos for a number of things like fear of flying, medical procedures,

etc. and he had to take very high doses to get an effect from these

drugs AND while not autistic, the doctor has ordered a number of tests,

some of which he tests abnormal for, and when I google these tests I

often find info about them on autism websites...including heavy metals,

gluten intolerance, urine porphyrins, urine pyrolles...

>http://www.nytimes.com/2009/11/03/health/03asperger.html?

>_r=3 & adxnnl=1 & adxnnlx=1257620445-pNzGOwH5beqwQgo41bSfEQ

thanks sue

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