Mitochondrial Disease in Autism: A Cohort Analysis

[Guest guest]

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

[Guest guest]

<<Twenty-four of 25 patients had one or more major clinical

abnormalities uncommon in idiopathic autism. >>

How can they make this statement? Thay cannot have a large enough data

bank to establish 'uncommon in idopathic autism'.. How many doctors

carry out such extensive tests?

Neno/Natasa schrieb:

>

> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

>

>

> ------------------------------------------------------------------------

>

> No virus found in this incoming message.

> Checked by AVG.

> Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release Date: 28/11/2008

19:31

>

[Guest guest]

This is a bit muddled I think because it distinguishes autistic children

with mito disorder from children with idiopathic autism -- then later

says that autistic children with mito disorder are a subset of children

with autism. I would be interested in how they are distinguishing

between children with autism with mito disorder and children with

idiopathic autism -- I wouldn't think sufficient work has been done to

describe " idiopathic autism " other than " children with autism but

without mito disorder " . But all descriptions of subsets encourage me,

TBH, because if they can distinguish subsets then they might distinguish

consistent responses to treatment and we might all stop the guessing games

xx Sally

Neno/Natasa wrote:

>

> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - http://www.avg.com

> Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date: 29/11/2008

10:37

>

>

[Guest guest]

This is a bit muddled I think because it distinguishes autistic children

with mito disorder from children with idiopathic autism -- then later

says that autistic children with mito disorder are a subset of children

with autism. I would be interested in how they are distinguishing

between children with autism with mito disorder and children with

idiopathic autism -- I wouldn't think sufficient work has been done to

describe " idiopathic autism " other than " children with autism but

without mito disorder " . But all descriptions of subsets encourage me,

TBH, because if they can distinguish subsets then they might distinguish

consistent responses to treatment and we might all stop the guessing games

xx Sally

Neno/Natasa wrote:

>

> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - http://www.avg.com

> Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date: 29/11/2008

10:37

>

>

[Guest guest]

Exactly, I agree. What is " idiopathic autism " in this context --

autistic children without mito disorder?

Sally

JULIE GRIFFITHS wrote:

>

> <<Twenty-four of 25 patients had one or more major clinical

> abnormalities uncommon in idiopathic autism. >>

>

> How can they make this statement? Thay cannot have a large enough data

> bank to establish 'uncommon in idopathic autism'.. How many doctors

> carry out such extensive tests?

>

>

>

> Neno/Natasa schrieb:

> >

> >

> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

> >

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>>

>

> >

> >

> >

> > ----------------------------------------------------------

> >

> > No virus found in this incoming message.

> > Checked by AVG.

> > Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release Date:

> 28/11/2008 19:31

> >

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - http://www.avg.com

> Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date: 29/11/2008

10:37

>

>

[Guest guest]

Exactly, I agree. What is " idiopathic autism " in this context --

autistic children without mito disorder?

Sally

JULIE GRIFFITHS wrote:

>

> <<Twenty-four of 25 patients had one or more major clinical

> abnormalities uncommon in idiopathic autism. >>

>

> How can they make this statement? Thay cannot have a large enough data

> bank to establish 'uncommon in idopathic autism'.. How many doctors

> carry out such extensive tests?

>

>

>

> Neno/Natasa schrieb:

> >

> >

> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

> >

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

> <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>>

>

> >

> >

> >

> > ----------------------------------------------------------

> >

> > No virus found in this incoming message.

> > Checked by AVG.

> > Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release Date:

> 28/11/2008 19:31

> >

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - http://www.avg.com

> Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date: 29/11/2008

10:37

>

>

[Guest guest]

Magnificent.

Again we see " typical autism " as if there were any such thing.

I suppose they put their finding at the top and their speculation in the

discussion. It's fair enough.

Sally

Neno/Natasa wrote:

>

>

> they do discuss that at great length in the Discussion part, and

> conclude with:

>

>

> Overall, our results demonstrate substantial clinical

> heterogeneity of individuals with co-occurring autism and defects

> of mitochondrial oxidative phosphorylation, *nearly all of whom we

> found to be clinically distinct from children with idiopathic

> autism*. *The data do not exclude the possibility of persons with

> isolated autism having a disorder of oxidative phosphorylation–_in

> fact, one of our patients did not have any major clinical features

> that distinguished her from typical autism_. In addition, _it is

> possible, if not likely_, that a still broader clinical,

> biochemical and genetic spectrum of mitochondrial autism exists.

> *

>

>

> my only grudge here is that they should have put this right at the

> top – in the abstract, not hidden at the very bottom.

>

> they could have also discussed possible treatment options, but

> didn’t venture there at all. (could be for political reasons, to

> get this past “peer review” quickly??)

>

>

>

>

>

>

>

>

>

> <<Twenty-four of 25 patients had one or more major clinical

> abnormalities uncommon in idiopathic autism. >>

>

> How can they make this statement? Thay cannot have a large enough

> data

> bank to establish 'uncommon in idopathic autism'.. How many doctors

> carry out such extensive tests?

>

>

>

> Neno/Natasa schrieb:

> >

> >

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

>

<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

> >

<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

> >

> >

> >

> > ----------------------------------------------------------

> >

> > No virus found in this incoming message.

> > Checked by AVG.

> > Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release Date:

> 28/11/2008 19:31

> >

>

>

>

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - http://www.avg.com

> Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date: 29/11/2008

10:37

>

>

[Guest guest]

Magnificent.

Again we see " typical autism " as if there were any such thing.

I suppose they put their finding at the top and their speculation in the

discussion. It's fair enough.

Sally

Neno/Natasa wrote:

>

>

> they do discuss that at great length in the Discussion part, and

> conclude with:

>

>

> Overall, our results demonstrate substantial clinical

> heterogeneity of individuals with co-occurring autism and defects

> of mitochondrial oxidative phosphorylation, *nearly all of whom we

> found to be clinically distinct from children with idiopathic

> autism*. *The data do not exclude the possibility of persons with

> isolated autism having a disorder of oxidative phosphorylation–_in

> fact, one of our patients did not have any major clinical features

> that distinguished her from typical autism_. In addition, _it is

> possible, if not likely_, that a still broader clinical,

> biochemical and genetic spectrum of mitochondrial autism exists.

> *

>

>

> my only grudge here is that they should have put this right at the

> top – in the abstract, not hidden at the very bottom.

>

> they could have also discussed possible treatment options, but

> didn’t venture there at all. (could be for political reasons, to

> get this past “peer review” quickly??)

>

>

>

>

>

>

>

>

>

> <<Twenty-four of 25 patients had one or more major clinical

> abnormalities uncommon in idiopathic autism. >>

>

> How can they make this statement? Thay cannot have a large enough

> data

> bank to establish 'uncommon in idopathic autism'.. How many doctors

> carry out such extensive tests?

>

>

>

> Neno/Natasa schrieb:

> >

> >

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815

>

<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

> >

<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

<http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003815>

>

> >

> >

> >

> > ----------------------------------------------------------

> >

> > No virus found in this incoming message.

> > Checked by AVG.

> > Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release Date:

> 28/11/2008 19:31

> >

>

>

>

>

>

> ------------------------------------------------------------------------

>

>

> No virus found in this incoming message.

> Checked by AVG - http://www.avg.com

> Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date: 29/11/2008

10:37

>

>

[Guest guest]

's commented on it too!

http://www.huffingtonpost.com/david-kirby/new-study---

mitochondrial_b_147030.html

> >

> >

> > they do discuss that at great length in the Discussion part,

and

> > conclude with:

> >

> >

> > Overall, our results demonstrate substantial clinical

> > heterogeneity of individuals with co-occurring autism and

defects

> > of mitochondrial oxidative phosphorylation, *nearly all of

whom we

> > found to be clinically distinct from children with idiopathic

> > autism*. *The data do not exclude the possibility of persons

with

> > isolated autism having a disorder of oxidative

phosphorylation–_in

> > fact, one of our patients did not have any major clinical

features

> > that distinguished her from typical autism_. In addition, _it

is

> > possible, if not likely_, that a still broader clinical,

> > biochemical and genetic spectrum of mitochondrial autism

exists.

> > *

> >

> >

> > my only grudge here is that they should have put this right

at the

> > top – in the abstract, not hidden at the very bottom.

> >

> > they could have also discussed possible treatment options, but

> > didn't venture there at all. (could be for political reasons,

to

> > get this past " peer review " quickly??)

> >

> >

> >

> >

> >

> >

> >

> >

> >

> > <<Twenty-four of 25 patients had one or more major clinical

> > abnormalities uncommon in idiopathic autism. >>

> >

> > How can they make this statement? Thay cannot have a large

enough

> > data

> > bank to establish 'uncommon in idopathic autism'.. How many

doctors

> > carry out such extensive tests?

> >

> >

> >

> > Neno/Natasa schrieb:

> > >

> > > http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815

> > <http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815>

> >

> > > <http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815>

> > <http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815>

> >

> > >

> > >

> > >

> > > ----------------------------------------------------------

> > >

> > > No virus found in this incoming message.

> > > Checked by AVG.

> > > Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release

Date:

> > 28/11/2008 19:31

> > >

> >

> >

> >

> >

> >

> > ------------------------------------------------------------------

------

> >

> >

> > No virus found in this incoming message.

> > Checked by AVG - http://www.avg.com

> > Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date:

29/11/2008 10:37

> >

> >

>

[Guest guest]

's commented on it too!

http://www.huffingtonpost.com/david-kirby/new-study---

mitochondrial_b_147030.html

> >

> >

> > they do discuss that at great length in the Discussion part,

and

> > conclude with:

> >

> >

> > Overall, our results demonstrate substantial clinical

> > heterogeneity of individuals with co-occurring autism and

defects

> > of mitochondrial oxidative phosphorylation, *nearly all of

whom we

> > found to be clinically distinct from children with idiopathic

> > autism*. *The data do not exclude the possibility of persons

with

> > isolated autism having a disorder of oxidative

phosphorylation–_in

> > fact, one of our patients did not have any major clinical

features

> > that distinguished her from typical autism_. In addition, _it

is

> > possible, if not likely_, that a still broader clinical,

> > biochemical and genetic spectrum of mitochondrial autism

exists.

> > *

> >

> >

> > my only grudge here is that they should have put this right

at the

> > top – in the abstract, not hidden at the very bottom.

> >

> > they could have also discussed possible treatment options, but

> > didn't venture there at all. (could be for political reasons,

to

> > get this past " peer review " quickly??)

> >

> >

> >

> >

> >

> >

> >

> >

> >

> > <<Twenty-four of 25 patients had one or more major clinical

> > abnormalities uncommon in idiopathic autism. >>

> >

> > How can they make this statement? Thay cannot have a large

enough

> > data

> > bank to establish 'uncommon in idopathic autism'.. How many

doctors

> > carry out such extensive tests?

> >

> >

> >

> > Neno/Natasa schrieb:

> > >

> > > http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815

> > <http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815>

> >

> > > <http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815>

> > <http://www.plosone.org/article/info%3Adoi%2F10.1371%

2Fjournal.pone.0003815>

> >

> > >

> > >

> > >

> > > ----------------------------------------------------------

> > >

> > > No virus found in this incoming message.

> > > Checked by AVG.

> > > Version: 7.5.552 / Virus Database: 270.9.11/1818 - Release

Date:

> > 28/11/2008 19:31

> > >

> >

> >

> >

> >

> >

> > ------------------------------------------------------------------

------

> >

> >

> > No virus found in this incoming message.

> > Checked by AVG - http://www.avg.com

> > Version: 8.0.176 / Virus Database: 270.9.11/1819 - Release Date:

29/11/2008 10:37

> >

> >

>