[abmd] new Jyonouchi: innate immunity in a subset of children with autism spectrum disorders

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http://www.jneuroinflammation.com/content/5/1/52

1: J

Neuroinflammation. 2008 Nov 21;5(1):52. [Epub ahead of print]

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Impact of innate immunity in a subset of children with autism

spectrum disorders: a case control study.

Jyonouchi

H, Geng

L, Cushing-Ruby

A, Quraishi

H.

ABSTRACT:

BACKGROUND: Among patients with autism spectrum disorders (ASD)

evaluated in our clinic, there appears to be a subset that can be

clinically distinguished from other ASD children because of frequent

infections (usually viral) accompanied by worsening behavioural

symptoms and/or loss/decrease in acquired skills. This study assessed

whether these clinical features of this ASD subset are associated with

atopy, asthma, food allergy (FA), primary immunodeficiency (PID), or

innate immune responses important in viral infections. METHODS: This

study included the ASD children described above (ASD test, N=26) and

the following controls: ASD controls (N=107), non-ASD controls with FA

(N=24), non-ASD controls with chronic rhinosinusitis/recurrent otitis

media (CRS/ROM; N=38), and normal controls (N=43). We assessed

prevalence of atopy, asthma, FA, CRS/ROM, and PID. Innate immune

responses were assessed by measuring production of proinflammatory and

counter-regulatory cytokines by peripheral blood mononuclear cells

(PBMCs) in response to agonists of Toll-like receptors (TLRs), with or

without pre-treatment of lipopolysaccharide (LPS), a TLR4 agonist.

RESULTS: Non-IgE mediated FA was equally prevalent in both ASD test and

ASD control groups, occurring at higher frequency than in the non-ASD

controls. Allergic rhinitis, atopic/non-atopic asthma, and atopic

dermatitis were equally prevalent among the study groups except for the

CRS/ROM group in which non-atopic asthma was more prevalent (52.6%).

CRS/ROM and specific polysaccharide antibody deficiency (SPAD) were

more prevalent in the ASD test group than in the ASD control, FA, and

normal control groups: 23.1% vs. <5% for CRS/ROS and 19.2% vs.

<1% for SPAD. However, CRS/ROM patients had the highest prevalence

of SPAD (34.2%). When compared to ASD and normal case controls, PBMCs

from 19 non-SPAD, ASD test group children produced: 1) less IL-1beta

with a TLR7/8 agonist, less IL-10 with a TLR2/6 agonist, and more IL-23

with a TLR4 agonist without LPS pre-treatment, and 2) less IL-1beta

with TLR4/7/8 agonists with LPS pre-treatment. These are cytokines

associated with the neuro-immune network. CONCLUSIONS: Clinical

features of the ASD test group were not associated with atopy, asthma,

FA, or PID in our study but may be associated with altered TLR

responses mediating neuro-immune interactions.

PMID: 19025588

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