Re: More on gluten and diabetes, and fish oil

[Guest guest]

There wasn't enough info to be sure, but they don't seem to have

considered the possiblity that the reuction in diabetees was due to

the decrease in carbs......

not that i have any doubt that gluten can trigger diabetes, i'm just

not sure their study proved it.

> Clin Immunol. 2004 Apr;111(1):108-18

>

> Delayed exposure to wheat and barley proteins reduces diabetes

incidence in

> non-obese diabetic mice.

>

> Schmid S, Koczwara K, Schwinghammer S, Lampasona V, Ziegler AG,

Bonifacio E.

>

> Diabetes Research Institute, Krankenhaus Munchen-Schwabing,

Munich, Germany.

>

> Dietary gluten, vitamin D3, and fish-oil are suggested to

influence the

> incidence of autoimmune diabetes. To determine whether

modification of

> their intake could reduce diabetes incidence and autoimmunity in

mice, pups

> from female non-obese diabetic (NOD) mice were fed diets modified

for

> protein source, fatty acid content, and/or vitamin D3 content and

were

> followed for diabetes development, insulin autoantibodies (IAA),

and

> insulitis. Replacement of wheat and barley with poultry as the

major

> protein source significantly affected diabetes development.

Diabetes onset

> was delayed and diabetes incidence was significantly reduced in

female mice

> that received the wheat and barley protein-free diet throughout

life (45%

> by age 32 weeks vs. 88% in control mice; P < 0.01), from weaning

(42%; P <

> 0.005), or from 3 to 10 weeks of age only (36%; P < 0.01), and

diabetes

> development was not completely restored by gliadin supplementation

of the

> wheat and barley protein-free diet (58%; P < 0.05). Insulin

autoantibodies

> (P < 0.01) and insulitis scores (P < 0.02) were reduced, and intra-

> pancreatic IL-4 mRNA increased (P < 0.05) in wheat and barley

protein-

> deprived mice. Diabetes incidence was neither reduced by fish-oil

or

> vitamin D3 supplementation alone, nor in mice fed a wheat and

barley

> protein-free diet that was supplemented with fish-oil and vitamin

D3. These

> data support a link between dietary wheat and barley proteins and

the

> development of autoimmune diabetes.

>

> PMID: 15093559 [PubMed - in process]