Re: Pubmed: efficacy of mb12 and folinic for kids with autism

[Guest guest]

sorry this was already posted, but can anyone tell me in mls how much

was being used of mb12 on these children? (dont have a scientific

head to work it out)

thanks

>

> http://www.ncbi.nlm.nih.gov/pubmed/19056591

>

>

>

> Efficacy of methylcobalamin and folinic acid treatment on

glutathione

> redox status in children with autism. SJ, Melnyk S, Fuchs G,

> Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW.

> Departments of Pediatrics and Biostatistics, University of Arkansas

> for Medical Sciences, Arkansas Children's Hospital Research

> Institute, Little Rock, AR.

>

> BACKGROUND: Metabolic abnormalities and targeted treatment trials

> have been reported for several neurobehavioral disorders but are

> relatively understudied in autism. OBJECTIVE: The objective of this

> study was to determine whether or not treatment with the metabolic

> precursors, methylcobalamin and folinic acid, would improve plasma

> concentrations of transmethylation/transsulfuration metabolites and

> glutathione redox status in autistic children. DESIGN: In an open-

> label trial, 40 autistic children were treated with 75 mug/kg

> methylcobalamin (2 times/wk) and 400 mug folinic acid (2 times/d)

for

> 3 mo. Metabolites in the transmethylation/transsulfuration pathway

> were measured before and after treatment and compared with values

> measured in age-matched control children. RESULTS: The results

> indicated that pretreatment metabolite concentrations in autistic

> children were significantly different from values in the control

> children. The 3-mo intervention resulted in significant increases

in

> cysteine, cysteinylglycine, and glutathione concentrations (P <

> 0.001). The oxidized disulfide form of glutathione was decreased

and

> the glutathione redox ratio increased after treatment (P < 0.008).

> Although mean metabolite concentrations were improved significantly

> after intervention, they remained below those in unaffected control

> children. CONCLUSIONS: The significant improvements observed in

> transmethylation metabolites and glutathione redox status after

> treatment suggest that targeted nutritional intervention with

> methylcobalamin and folinic acid may be of clinical benefit in some

> children who have autism. This trial was registered at

> clinicaltrials.gov as NCT00692315.

>

[Guest guest]

75 mug/kg (per kilo) methylcobalamin

think mug is the same as mcg, miligrams – someone correct me!

nx

sorry this was already posted, but can anyone tell me in mls how much

was being used of mb12 on these children? (dont have a scientific

head to work it out)

thanks

>

> http://www.ncbi.nlm.nih.gov/pubmed/19056591

>

>

>

> Efficacy of methylcobalamin and folinic acid treatment on

glutathione

> redox status in children with autism. SJ, Melnyk S, Fuchs G,

> Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW.

> Departments of Pediatrics and Biostatistics, University of Arkansas

> for Medical Sciences, Arkansas Children's Hospital Research

> Institute, Little Rock, AR.

>

> BACKGROUND: Metabolic abnormalities and targeted treatment trials

> have been reported for several neurobehavioral disorders but are

> relatively understudied in autism. OBJECTIVE: The objective of this

> study was to determine whether or not treatment with the metabolic

> precursors, methylcobalamin and folinic acid, would improve plasma

> concentrations of transmethylation/transsulfuration metabolites and

> glutathione redox status in autistic children. DESIGN: In an open-

> label trial, 40 autistic children were treated with 75 mug/kg

> methylcobalamin (2 times/wk) and 400 mug folinic acid (2 times/d)

for

> 3 mo. Metabolites in the transmethylation/transsulfuration pathway

> were measured before and after treatment and compared with values

> measured in age-matched control children. RESULTS: The results

> indicated that pretreatment metabolite concentrations in autistic

> children were significantly different from values in the control

> children. The 3-mo intervention resulted in significant increases

in

> cysteine, cysteinylglycine, and glutathione concentrations (P <

> 0.001). The oxidized disulfide form of glutathione was decreased

and

> the glutathione redox ratio increased after treatment (P < 0.008).

> Although mean metabolite concentrations were improved significantly

> after intervention, they remained below those in unaffected control

> children. CONCLUSIONS: The significant improvements observed in

> transmethylation metabolites and glutathione redox status after

> treatment suggest that targeted nutritional intervention with

> methylcobalamin and folinic acid may be of clinical benefit in some

> children who have autism. This trial was registered at

> clinicaltrials.gov as NCT00692315.

>

[Guest guest]

There are 1000mcg[same as mug, which is microgram] in one milligram

[mg]. So if you have a 50kg child, the dose in the study would be

50kg x 75mcg = 3750mcg. The methyl B12 solution we use is

25,000mg/ml. At that concentration, the 50kg child would be getting

0.15cc - it is figured 3750mcg/xcc = 25,0000mcg/1cc. You have to know

the concentration of the B12 before you can figure the ml you give.

Hope this helps,

> >> >

> >> > http://www.ncbi.nlm.nih.gov/pubmed/19056591

> >> >

> >> >

> >> >

> >> > Efficacy of methylcobalamin and folinic acid treatment on

> > glutathione

> >> > redox status in children with autism. SJ, Melnyk S, Fuchs

G,

> >> > Reid T, Jernigan S, Pavliv O, Hubanks A, Gaylor DW.

> >> > Departments of Pediatrics and Biostatistics, University of

Arkansas

> >> > for Medical Sciences, Arkansas Children's Hospital Research

> >> > Institute, Little Rock, AR.

> >> >

> >> > BACKGROUND: Metabolic abnormalities and targeted treatment

trials

> >> > have been reported for several neurobehavioral disorders but

are

> >> > relatively understudied in autism. OBJECTIVE: The objective of

this

> >> > study was to determine whether or not treatment with the

metabolic

> >> > precursors, methylcobalamin and folinic acid, would improve

plasma

> >> > concentrations of transmethylation/transsulfuration

metabolites and

> >> > glutathione redox status in autistic children. DESIGN: In an

open-

> >> > label trial, 40 autistic children were treated with 75 mug/kg

> >> > methylcobalamin (2 times/wk) and 400 mug folinic acid (2

times/d)

> > for

> >> > 3 mo. Metabolites in the transmethylation/transsulfuration

pathway

> >> > were measured before and after treatment and compared with

values

> >> > measured in age-matched control children. RESULTS: The results

> >> > indicated that pretreatment metabolite concentrations in

autistic

> >> > children were significantly different from values in the

control

> >> > children. The 3-mo intervention resulted in significant

increases

> > in

> >> > cysteine, cysteinylglycine, and glutathione concentrations (P <

> >> > 0.001). The oxidized disulfide form of glutathione was

decreased

> > and

> >> > the glutathione redox ratio increased after treatment (P <

0.008).

> >> > Although mean metabolite concentrations were improved

significantly

> >> > after intervention, they remained below those in unaffected

control

> >> > children. CONCLUSIONS: The significant improvements observed in

> >> > transmethylation metabolites and glutathione redox status after

> >> > treatment suggest that targeted nutritional intervention with

> >> > methylcobalamin and folinic acid may be of clinical benefit in

some

> >> > children who have autism. This trial was registered at

> >> > clinicaltrials.gov as NCT00692315.

> >> >

> >

> >

> >

>